Telomere shortening in T cells correlates with Alzheimer's disease status

Offspring's Leukocyte Telomere Length, Paternal Age, and Telomere Elongation in Sperm

“…Environmental factors, including smoking [3,10], obesity [9][10][11], psychological stress [12] and low socio-economic status (SES) [13] are ostensibly associated with shortened LTL, underscoring the roles of not only genetic factors but also the environment in fashioning leukocyte telomere dynamics (length and attrition rate). Shortened LTL is also observed in individuals with aging-related diseases, including hypertension [1,7], insulin resistance [11,14,15], atherosclerosis [16,17], myocardial infarction [16,18,19], stroke [9] and dementia [20,21]. Further, aging itself may modify the relationship between LTL and some of these variables [reviewed 22].…”

Innate Immune Responses in the Geriatric Population

“…Alzheimer patients present reduced telomere length in PBMCs compared to control. There was also a significant correlation between T cell telomere length and MMSE score, CD28 expression and an inverse correlation between serum TNF production and telomere shortening in T cells (Panossian et al, 2003). Telomere shortening is also correlated with duration of type 1 and type 2 diabetes and systolic blood pressure but not with diabetes complications (Astrup et al, 2010;Sampson et al, 2006).…”

An overview on the role of telomere , telomerase in degenerative diseases and cancer

“…There are some studies connecting the telomere length to Alzheimer's disease. Panossian L. A. et al [17] first found that patients with AD had shorter telomere lengths in peripheral blood mononuclear cells than that of the age-matched control subjects. Then, Jenkins E. C et al [18] found that older females with Down syndrome and AD-type dementia had shorter T-cell telomeres than that of the age-matched counterpart.…”