Abstract:Mutations in the telomere binding protein, POT1 are associated with solid tumors and leukemias. POT1 alterations cause rapid telomere elongation, ATR kinase activation, telomere fragility, and accelerated tumor development. Here, we investigated the impact of mutant POT1 alleles through complementary genetic and proteomic approaches based on CRISPR-interference and biotinbased proximity labelling, respectively. These screens revealed that replication stress is a major vulnerability in cells expressing mutant P… Show more
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