Telomere lengths are characteristic in each human individual

Takubo, Kaiyo; Izumiyama-Shimomura, Naotaka; Honma, Naoko; Sawabe, Motoji; Arai, Tomio; Kato, Minoru; Oshimura, Mitsuo; Nakamura, Kenichi

doi:10.1016/s0531-5565(01)00218-2

Cited by 271 publications

(257 citation statements)

References 30 publications

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“…3a). This finding is compatible with our former observation that telomere length appears unique to each individual and correlated across many tissues in the body (Takubo et al 2002). Another noteworthy finding of our present study was that the correlation of NTCR between β and α cells was significant only in adults and not in younger subjects (Fig.…”

Section: Discussionsupporting

confidence: 94%

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Telomere attrition in beta and alpha cells with age

Tamura

Izumiyama-Shimomura

Kimbara

et al. 2016

AGE

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We have reported telomere attrition in β and α cells of the pancreas in elderly patients with type 2 diabetes, but it has not been explored how the telomere lengths of these islet cells change according to age in normal subjects. To examine the telomere lengths of β and α cells in individuals without diabetes across a wide range of ages, we conducted measurement of the telomere lengths of human pancreatic β and α cells obtained from 104 autopsied subjects without diabetes ranging in age from 0 to 100 years. As an index of telomere lengths, the normalized telomere-centromere ratio (NTCR) was determined for β (NTCRβ) and α (NTCRα) cells by quantitative fluorescence in situ hybridization (Q-FISH). We found NTCRβ and NTCRα showed almost the same levels and both decreased according to age (p < 0.001 for both). NTCRs decreased more rapidly with age and were more widely distributed (p = 0.036 for NTCRβ, p < 0.001 for NTCRα) in subjects under 18 years of age than in subjects over 18 years. There was a positive correlation between NTCRβ and NTCRα only among adult subjects (p < 0.001). In conclusion, the telomeres of β and α cells become shortened with normal aging process.

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Section: Discussionsupporting

confidence: 94%

“…Our group has reported that telomere attrition with age occurs in cells of various organs, except for cerebral cortex cells and myocardial cells (Takubo et al 2002;Takubo et al 2010a). However, no reported studies have examined changes in telomere length with age in pancreatic islet cells.…”

Section: Introductionmentioning

confidence: 98%

Telomere attrition in beta and alpha cells with age

Tamura

Izumiyama-Shimomura

Kimbara

et al. 2016

AGE

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“…Nakamura et al, 2002;Sugimoto et al, 2006). Significant correlations were found between telomere lengths in different tissues within individual humans Takubo et al, 2002). The reason why we could not find significant correlations both between age and telomere length and between telomere lengths in different tissues within individuals may be due to a limited sample size (n = 20).…”

mentioning

confidence: 72%

“…In the present study, we verified whether telomere length shortens with age in the loggerhead sea turtle (Caretta caretta) by measuring telomere lengths in blood and epidermis from captive individuals whose ages and histories are known. We also examined whether there is some correlation between telomere lengths in different tissues within individuals, as has been shown in humans Takubo et al, 2002). Blood and epidermis samples were collected from 20 captive loggerhead turtles at the Port of Nagoya Public Aquarium (PNPA), Nagoya, Aichi, Japan, in late November 2007.…”

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confidence: 99%

Shorter telomere length with age in the loggerhead turtle: a new hope for live sea turtle age estimation

et al. 2008

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We verified whether telomere length shortens with age in the loggerhead sea turtle (Caretta caretta) by measuring telomere lengths (relative telomere to single copy gene [T/S] ratios) in whole blood and epidermis from 20 captive individuals with a real-time PCR method. There was no significant correlation between age and relative T/S ratios in blood. Although the correlation between age and relative T/S ratios in epidermis was not significant, older turtles had smaller relative T/S ratios in epidermis. It was thus demonstrated that telomere length in epidermis could be a useful age estimator for sea turtles. Relative age information obtained with this simple, rapid, non-invasive technique may help to advance our understanding of the ecology of endangered sea turtles. This is the first publication on age-related changes in telomere length among chelonians.

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“…Loss of the distal region of telomeres correlates with the decline of the proliferative life-span of cells both in vitro and in vivo [138,139]. Using regression analysis of data on rates of telomere length reduction in 15 human cells, tissues and organs, Takubo et al [140] have shown their values within the range of 20Á/60 bp/year. The authors stressed that telomere lengths did not show clear correlation with tissue renewal times in vivo, but rather were characteristic for individuals.…”

Section: Cellular Senescence and Carcinogenesismentioning

confidence: 99%

The relationship between aging and carcinogenesis: a critical appraisal

Anisimov

2003

Critical Reviews in Oncology/Hematology

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The incidence of cancer increases with age in humans and in laboratory animals alike. There are different patterns of age-related distribution of tumors in different organs and tissues. Aging may increase or decrease the susceptibility of various tissues to initiation of carcinogenesis and usually facilitates promotion and progression of carcinogenesis. Aging may predispose to cancer by several mechanisms: (1) tissue accumulation of cells in late stages of carcinogenesis; (2) alterations in homeostasis, in particular, alterations in immune and endocrine system and (3) telomere instability linking aging and increased cancer risk. Increased susceptibility to the effects of tumor promoters is found both in aged animals and aged humans, as predicted by the multistage model of carcinogenesis. Available evidence supporting the relevance of replicative senescence of human cells and telomere biology to human cancer seems quite strong, however, the evidence linking cellular senescence to human aging is controversial and required additional stuidies. Data on the acceleration of aging by carcinogenic agents as well as on increased cancer risk in patients with

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Telomere lengths are characteristic in each human individual

Cited by 271 publications

References 30 publications

Telomere attrition in beta and alpha cells with age

Telomere attrition in beta and alpha cells with age

Shorter telomere length with age in the loggerhead turtle: a new hope for live sea turtle age estimation

The relationship between aging and carcinogenesis: a critical appraisal

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