Telomere length mediates the association between polycyclic aromatic hydrocarbons exposure and abnormal glucose level among Chinese coke oven plant workers

Zhang, Bin; Liu, Lu; Lan, Guo-Cheng; Guo, Shugang; Zhao, Xinyu; Butler, James J.; Li, Qiang; Jiang, Liuquan; Pan, Baolong; Nie, Jing; Yang, Jin

doi:10.1016/j.chemosphere.2020.129111

Cited by 17 publications

(3 citation statements)

References 62 publications

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“…They found the concentration of 12 polycyclic aromatic hydrocarbons in the peripheral blood of the exposure group was significantly higher than that of the control group. Besides, the detection rate of sleep disorder in the exposure group was higher than that in the control group (55). Unlike the above study, our study focused the linear and non-linear association between urinary PAHs with SSD and self-reported trouble sleeping in the general US.…”

Section: Discussionmentioning

confidence: 85%

Urinary polycyclic aromatic hydrocarbon metabolites were associated with short sleep duration and self-reported trouble sleeping in US adults: data from NHANES 2005–2016 study population

Han

Wang

2023

Front. Public Health

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BackgroundThe aim of the current study was to investigate the link between human exposure to PAHs with short sleep duration (SSD) and self-reported trouble sleeping.MethodsA total of 9,754 participants and 9,777 participants obtained from NHANES 2005–2016 were included in this cross-sectional study about SSD and self-reported trouble sleeping, respectively. The association between urinary PAHs metabolites with the prevalence of SSD and self-reported trouble sleeping by the weighted multivariate logistic regression model, restricted cubic spline (RCS) curves, and weighted quantile sum (WQS) regression.ResultsAfter adjusting for all covariates, 1-hydroxynapthalene, 2-hydroxynapthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxyphenanthrene demonstrated positive associations with SSD prevalence. Besides, 1-hydroxynapthalene, 2-hydroxynapthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, 1-hydroxyphenanthrene, and 1-hydroxyphenanthrene exhibited positive associations with the prevalence of self-reported trouble sleeping following the adjustment for all covariates. RCS curves confirmed the non-linear associations between 1-hydroxynapthalene, 2-hydroxynapthalene, 3-hydroxyfluorene, 2-hydroxyfluorene, and 1-hydroxyphenanthrene with the prevalence of SSD, and 1-hydroxynapthalene, 3-hydroxyfluorene, and 2-hydroxyfluorene with the prevalence of self-reported trouble sleeping. The WQS results showed that mixed exposure to PAH metabolites had a significant positive association with the prevalence of SSD (OR: 1.087, 95% CI: 1.026, 1.152, p = 0.004) and self-reported trouble sleeping (OR: 1.190, 95% CI: 1.108, 1.278, p < 0.001).ConclusionUrinary concentrations of PAH metabolites exhibited a close association with the prevalence of SSD and self-reported trouble sleeping in US adults. More emphasis should be placed on the importance of environmental effects on sleep health.

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Section: Discussionmentioning

confidence: 85%

Urinary polycyclic aromatic hydrocarbon metabolites were associated with short sleep duration and self-reported trouble sleeping in US adults: data from NHANES 2005–2016 study population

Han

Wang

2023

Front. Public Health

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“…However, the current finding revealed that random blood glucose in all groups was within normal limits. On the other hand, other study found that urine poly-aromatic hydrocarbon (PAHs) were linked to a higher incidence of elevated glucose levels than other group without contact with PAHs (22) . Generally, the endocrine involvement of chronic exposure to fuel waste products or air pollution may be the end results of subsequent organs dysfunctions (23) .…”

Section: Discussionmentioning

confidence: 97%

Assessment of Certain Hematological Indices and Interlukin-6 in Workers and Individuals Who Live Near to Crude Oil Wells in Middle Petroleum

Alghara¹,

Jaccob

Jabbar³

2023

IJPS

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Environmental exposures to a variety of pollutant elements especially fuel waste products may result in harmful impacts on several physiological systems. The inflammatory response and the hematological system are the major affected systems. The aim of the study is to reveal the impact of oil exposure on several hematological parameters and IL-6 of oil workers and to detect which parameters are more affected as prognosticators for clinical disorders. This study included three groups, 50 persons in each. Control group; Group1 workers at oil wells; and Group2 who live close to oil wells. Physical parameters, serum interleukin 6 , random blood glucose , hematological parameters are measured. Significant rise in pulse rate, serum interleukin 6 and RBG were documented in workers. Hematological parameters were adversely affected by air pollution . We found a significant rise in platelet count in Group 1 patients . The correlation between IL-6 and certain hematological indices revealed that each of WBC and platelets were significantly correlated to IL-6. In conclusion People work or lived close to oil wells area showed alterations in hematological and inflammatory parameters may be related to continuous exposure to petrol fumes, which also results in a considerable increase in interleukin-6. Keyword:Oil wells, hematological indices, interleukin 6.

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“…It has been increasing among adults [13], children, and adolescents for the past few years [14]. Recently, increasing attention has been given to the relationship between environmental pollutants, especially PAH exposure and metabolic disorders such as dyslipidemia [15], blood pressure [16], blood glucose [17], and obesity [18] among adults and adolescents. However, evidence on the association between PAHs and MetS is limited.…”

Section: Introductionmentioning

confidence: 99%

Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components

Chen

Peng

et al. 2023

Obesity

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Objective: This study aimed to evaluate the relationship of polycyclic aromatic hydrocarbon (PAH) exposure with metabolic syndrome (MetS) and its components and to explore the potential mechanism.Methods: Participants from the National Health and Nutrition Examination Survey (NHANES 2001(NHANES -2016 were included.Results: A total of 6532 adults and 1237 adolescents were included in the present analysis. For adults, the odds ratios (ORs) and 95% CIs for each one-unit increase in the log-transformed level of 1-hydroxynaphthalene (1-OHNa), 2-hydroxynaphthalene (2-OHNa), 3-hydroxyfluorene (3-OHFlu), 2-hydroxyfluorene (2-OHFlu), 1hydroxyphenanthrene (1-OHPh), 1-hydroxypyrene (1-OHP), 2-and 3-hydroxyphenanthrene (2&3-OHPh), and total urinary PAH metabolites ( P OH-PAHs) with MetS

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Telomere length mediates the association between polycyclic aromatic hydrocarbons exposure and abnormal glucose level among Chinese coke oven plant workers

Cited by 17 publications

References 62 publications

Urinary polycyclic aromatic hydrocarbon metabolites were associated with short sleep duration and self-reported trouble sleeping in US adults: data from NHANES 2005–2016 study population

Urinary polycyclic aromatic hydrocarbon metabolites were associated with short sleep duration and self-reported trouble sleeping in US adults: data from NHANES 2005–2016 study population

Assessment of Certain Hematological Indices and Interlukin-6 in Workers and Individuals Who Live Near to Crude Oil Wells in Middle Petroleum

Association of polycyclic aromatic hydrocarbons with systemic inflammation and metabolic syndrome and its components

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