Telomere Length in White Blood Cell DNA and Lung Cancer: A Pooled Analysis of Three Prospective Cohorts

Seow, Wei Jie; Cawthon, Richard M.; Purdue, Mark P.; Hu, Wei; Gao, Yu Tang; Huang, Wen Yi; Weinstein, Stephanie J.; Ji, Bu Tian; Virtamo, Jarmo; Hosgood, H. Dean; Bassig, Bryan A.; Shu, Xiao Ou; Cai, Qiuyin; Xiang, Yong Bing; Shen, Min; Chow, Wong Ho; Berndt, Sonja I.; Kim, Christopher; Lim, Unhee; Albanês, Demetrius; Caporaso, Neil E.; Chanock, Stephen; Wang, Zheng; Rothman, Nathaniel; Lan, Qing

doi:10.1158/0008-5472.can-14-0459

Cited by 114 publications

(110 citation statements)

References 41 publications

(43 reference statements)

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“…39 However, based on prospective studies, a consensus is now building that major cancers (including sporadic melanoma, adenocarcinoma of the lung, and cancers of the breast, pancreas, and prostate) are associated with an inherently longer LTL. [11][12][13][14][15] Our results suggest that the propensity to major cancers associated with long LTL might already be present at birth.…”

Section: Figurementioning

confidence: 60%

“…The ramifications of LTL dynamics for human health are an area of active research. Although short LTL is associated with increased risk of atherosclerotic cardiovascular disease [5][6][7] and diminished longevity, [8][9][10] long LTL is associated with major cancers, including melanoma, 11 adenocarcinoma of the lung, 12 cancers of the breast 13 and pancreas, 14 and aggressive cancer of the prostate. 15 LTL research has been predominantly performed in adults.…”

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confidence: 99%

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Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease

Factor-Litvak¹,

Süsser

Kezios³

et al. 2016

Pediatrics

201

197

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BACKGROUND AND OBJECTIVE: In adults, leukocyte telomere length (LTL) is variable, familial, and longer in women and in offspring conceived by older fathers. Although short LTL is associated with atherosclerotic cardiovascular disease, long LTL is associated with major cancers. The prevailing notion is that LTL is a "telomeric clock, " whose movement (expressed in LTL attrition) reflects the pace of aging. Accordingly, individuals with short LTL are considered to be biologically older than their peers. Recent studies suggest that LTL is largely determined before adulthood. We examined whether factors that largely characterize LTL in adults also influence LTL in newborns.

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Section: Figurementioning

confidence: 60%

mentioning

confidence: 99%

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease

Factor-Litvak¹,

Süsser

Kezios³

et al. 2016

Pediatrics

201

197

View full text Add to dashboard Cite

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“…44 This is further supported by an independent study that demonstrated a pronounced association between telomere length and lung cancer risk in female adenocarcinoma cases. 45 Longer telomeres in females were reported in several other studies including a recent meta-analysis. 46-48 Estrogen may explain gender difference with respect to telomere length.…”

Section: Discussionmentioning

confidence: 70%

Telomere Length and Recurrence Risk after Curative Resection in Patients with Early-Stage Non–Small-Cell Lung Cancer: A Prospective Cohort Study

Kim

Vaporciyan

et al. 2015

Journal of Thoracic Oncology

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Background We hypothesized that telomere length in peripheral blood would have significant predictive value for risk of recurrence after curative resection in non-small cell lung cancer (NSCLC). Methods This prospective study included 473 patients with histologically confirmed early stage NSCLC who underwent curative resection at MD Anderson Cancer Center between 1995 and 2008. Relative telomere length (RTL) of peripheral leukocytes was measured by real-time PCR. The risk of recurrence was estimated as hazard ratios (HRs) and 95% confidence intervals (CIs) using a multivariable Cox proportional hazard regression model. Results Median duration of follow-up was 61 months and 151 patients (32%) had developed recurrence at time of analysis. Patients who developed recurrence had significantly longer mean RTL compared to those without recurrence (1.13 vs 1.07, P=0.046). A subgroup analysis indicates that women had longer RTL compared to males (1.12 vs 1.06, P=0.025), and the patients with adenocarcinoma demonstrated longer RTL compared to those with other histologic types (1.11 vs 1.05, P=0.042). To determine if longer RTL in women and adenocarcinoma subgroup would predict risk of recurrence, multivariate Cox analysis adjusting for age, gender, stage, pack year and treatment regimens was performed. Longer telomeres were significantly associated with higher risk of developing recurrence in female (HR=2.25; 95% CI, 1.02-4.96, P=0.044) and adenocarcinoma subgroups (HR=2.19; 95% CI, 1.05-4.55, P=0.036). The increased risk of recurrence due to long RTL was more apparent in females with adenocarcinoma (HR=2.67; 95% CI, 1.19-6.03, P=0.018). Conclusions This is the first prospective study to suggest that long RTL is associated with recurrence in early stage NSCLC after curative resection. Women and adenocarcinoma appear to be special subgroups in which telomere biology may play an important role.

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“…In some types of cancers, such as gastric and bladder cancer, shorter RTL in leukocytes was a risk factor of tumorigenesis, [12,13,21] while it was opposite in lung and colorectal cancer. [17,18] …”

Section: Discussionmentioning

confidence: 99%

Association of telomere length in peripheral leukocytes with chronic hepatitis B and hepatocellular carcinoma

Cai

et al. 2016

Medicine

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Background & Objectives:Telomere plays a critical role in the maintenance of genomic stability in eukaryotic chromosomes. More and more findings have shown that alteration in telomere length may involve in normal somatic cells and some diseases, however, whether the telomere length is associated with the development and/or progression of hepatic diseases remains poorly understood.Methods:A case–control study was employed to illustrate the correlation of relative telomere length (RTL) with chronic hepatitis B (CHB) and hepatocellular carcinoma (HCC). In this study, 152 patients with HCC, 212 patients with CHB, and 184 healthy controls were recruited. Genomic deoxyribonucleic acid (DNA) was extracted from the peripheral blood leukocytes, and fluorescence quantitative polymerase chain reaction (FQ-PCR) was used to detect telomere repeated numbers and 36B4 copy numbers. The RTL was calculated by telomere repeat copy number to single-copy gene number ratio in each sample compared with a reference DNA sample.Results:We found that the RTL in HCC group was the longest, followed by CHB group, and healthy control group was the shortest, showing significant statistical differences. When participants were categorized into longer and shorter group according to medium value in healthy controls, individuals who had longer RTL had a significant increased risk of CHB (odds ratio [OR]: 1.83, 95% confidence interval [CI]: 1.22–2.73) when the healthy control was used as the reference groups; furthermore, longer RTL also showed higher incidence of HCC (OR: 3.22, 95% CI: 2.01–5.17; OR: 1.58, 95% CI:1.03–2.41) when healthy control and CHB were used as the reference groups, respectively. When participants were categorized further into 4 groups according to quartile values of RTL in healthy controls, it showed that the longest RTL was also associated with an increased risk of CHB (OR: 2.09, 95% CI: 1.17–3.74) and HCC (OR: 4.31, 95% CI: 2.18–8.52; OR: 2.86, 95% CI: 1.53–5.34) when control and control/CHB group were used as the reference groups, respectively.Conclusion:Our results suggest that the alteration of telomere length in peripheral leukocytes might be involved in the hepatitis B virus infection and HCC events, and RTL might be a potential useful predictor of CHB and HCC.

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Telomere Length in White Blood Cell DNA and Lung Cancer: A Pooled Analysis of Three Prospective Cohorts

Cited by 114 publications

References 41 publications

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease

Leukocyte Telomere Length in Newborns: Implications for the Role of Telomeres in Human Disease

Telomere Length and Recurrence Risk after Curative Resection in Patients with Early-Stage Non–Small-Cell Lung Cancer: A Prospective Cohort Study

Association of telomere length in peripheral leukocytes with chronic hepatitis B and hepatocellular carcinoma

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