Telomere length in patients with osteoarthritis: a systematic review and meta-analysis

Xie, Huimin; Ma, Yubo; Shao, Ming; Kong, Jiangping; Zhou, Tingting; Wang, Feier; Cai, Guoqi; Xu, Shaochun; Pan, Faming

doi:10.1007/s40520-021-01944-6

Cited by 7 publications

(6 citation statements)

References 53 publications

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“…2018; Manoy et al, 2020). Similarly, a recently published metaanalysis including ten studies indicates that TL might be a potential biomarker of OA (Xie et al, 2021). On the contrary, as is suggested in another study, there is no association between TL and OA after adjusting age (Tamayo et al, 2010).…”

Section: Discussionmentioning

confidence: 81%

Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis

Yang

Cai

et al. 2021

Front. Genet.

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Objective: This two-sample Mendelian randomization (MR) study aimed to examine the potential causal association of telomere length (TL) with the risk of osteoarthritis (OA).Method: The summary-level data for OA was derived from the United Kingdom Biobank cohort, including 50,508 individuals of European descent. Eighteen single nucleotide polymorphisms associated with TL were identified as instrumental variables from the most up-to-date TL genome-wide association study (GWAS) involving over 78,592 individuals of European descent. Based on the GWASs data, MR was performed using established statistical analysis methods including the inverse variance weighted, weighted median, MR-Egger, and MR pleiotropy residual sum and outlier.Results: Genetically determined TL was not associated with the risk of total OA (IVW odds ratio [OR] = 1.00, 95% confidence interval [CI] = 0.83, 1.21). In subgroup analyses stratified by OA site, no evidence in favor of association between genetically determined TL and knee OA was found (IVW OR = 1.18, 95% CI = 0.89, 1.58). However, using WM method, we observed a limited protective effect of longer TL on the risk of hip OA (OR = 0.60, 95% CI = 0.36–0.99), whereas the results of the IVW (p = 0.931) and MR-PRESSO (p = 0.932) showed that TL had no effect on hip OA.Conclusions: This study does not support a causal association between TL and total OA. A potential protective association between longer TL and hip OA, though possible, remains less certain.

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Section: Discussionmentioning

confidence: 81%

Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis

Yang

Cai

et al. 2021

Front. Genet.

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“…Several extensive studies, in contrast to the aforementioned, found no significant links between LTL, bone mineral density, and osteoporosis (140)(141)(142). The meta-analysis that included 678 osteoarthritis (OA) patients and 1457 healthy subjects (143) showed shorter TL in individuals with OA than in healthy controls. The findings imply that TL is linked to the etiology and development of OA, and more research in this area will aid in understanding the function of TL in OA pathology.…”

Section: Osteoporosis and Osteoarthritismentioning

confidence: 92%

Telomere length as a biomarker of aging and diseases

Guzonjić¹,

Sopić²,

Ostanek³

et al. 2022

Arhiv za farmaciju

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As research related to healthspan and lifespan has become a hot topic, the necessity for a reliable and practical biomarker of aging (BoA), which can provide information about mortality and morbidity risk, along with remaining life expectancy, has increased. The chromosome terminus non-coding protective structure that prevents genomic instability is called a telomere. The continual shortening of telomeres, which affects their structure as well as function, is a hallmark of agedness. The aforementioned process is a potential cause of age-related diseases (ARDs), leading to a bad prognosis and a low survival rate, which compromise health and longevity. Hence, studies scrutinizing the BoAs often include telomere length (TL) as a prospective candidate. The results of these studies suggest that TL measurement can only provide an approximate appraisal of the aging rate, and its implementation into clinical practice and routine use as a BoA has many limitations and challenges. Nevertheless, measuring TL while determining other biomarkers can be used to assess biological age. This review focuses on the importance of telomeres in health, senescence, and diseases, as well as on summarizing the results and conclusions of previous studies evaluating TL as a potential BoA.

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“…Accelerated telomere shortening is associated with many ageing‐related diseases, including osteoarthritis 7‐10 . Telomere shortening of 50–150 base pairs (bp) occurs naturally with every division of the cell, since the linear structure of DNA ends cannot be fully replicated 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Sex‐specific differences in telomere length of patients with primary knee osteoarthritis

Kuszel,

Trzeciak,

Begier‐Krasinska

et al. 2024

J Cellular Molecular Medi

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Accelerated telomere shortening is associated with age‐related diseases, including osteoarthritis (OA). We aimed to determine the relative telomere length (TL) in leukocytes and cartilage of patients with primary knee OA and to investigate factors that may affect TL in OA. Relative TL measurements were performed using qPCR in leukocytes of 612 individuals (310 patients with primary knee OA undergoing total knee arthroplasty (TKA) and 302 unaffected controls). We also analysed cartilage in 57 of the 310 OA patients, measuring relative TL in severely affected and less affected (control) cartilage collected from the same knee. Cartilage TLs were compared to leukocyte TLs in all 57 patients. A significant sex‐by‐disease‐status interaction was found in regard to relative TL. Controlling for age, the average difference of leukocyte TL between female OA patients versus female controls was 0.217 units greater than that between male OA patients versus male controls (95% CI; [0.014, 0.421]). Relative TL comparison of severely and less affected cartilage samples from the same joint showed attrition of telomeres corresponding to disease severity (0.345 mean TL difference with 95% CI of [0.151, 0.539]) in the joint. We also noted that both severely and less affected cartilage had shorter telomeres than leukocytes collected from the same patient. Severe and moderate pain in OA patients was associated with shorter TL in leukocytes, but there was no association with depression or smoking in leukocytes and cartilage. Our study indicates that sex is an important factor in OA contributing to leukocyte and cartilage TL and that pain in OA shows an inverse association only with leukocyte TL.

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Telomere length in patients with osteoarthritis: a systematic review and meta-analysis

Cited by 7 publications

References 53 publications

Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis

Genetically Predicted Longer Telomere Length May Reduce Risk of Hip Osteoarthritis

Telomere length as a biomarker of aging and diseases

Sex‐specific differences in telomere length of patients with primary knee osteoarthritis

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