Telomere length in children environmentally exposed to low-to-moderate levels of lead

Pawlas, Natalia; Płachetka, Anna; Kozłowska, Agnieszka; Broberg, Karin; Kasperczyk, Sławomir

doi:10.1016/j.taap.2015.05.005

Cited by 38 publications

(28 citation statements)

References 72 publications

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“…Patients with myelodysplastic syndromes occupationally exposed to paints and pesticides, although there is no information about the kind of crop, had decreased TL [reviewed by Zhang et al, ]. Furthermore, environmental exposure to metals has been shown to shorten TL [Pawlas et al, ; Zota et al, ]. On the other hand, Dioni et al [] analyzed the effects of short‐term exposure to inhalable particulate matter on TL and telomerase expression in steel workers.…”

Section: Discussionmentioning

confidence: 99%

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

Kahl

Simon

Salvador

et al. 2015

Environ and Mol Mutagen

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Occupational exposure to pesticides in tobacco fields causes genetic damage in farmers. The aim of this study was to analyze tobacco farmers chronically exposed to low doses of pesticides and nicotine (present in the tobacco leaves) in relation to absolute telomere length (aTL), and explore the influence of lifestyle characteristics, oxidative stress, and inorganic element levels. DNA was isolated from peripheral blood samples from agricultural workers and non-exposed individuals, and aTL was measured by quantitative real time polymerase chain reaction (qPCR) analysis. Oxidative stress (thiobarbituric acid reactive substances [TBARS], which measures oxidative damage to lipids; and toxic equivalent antioxidant capacity [TEAC], which measures total equivalent antioxidant capacity) was evaluated in serum, and inorganic element content was analyzed in whole blood through particle-induced X-ray emission technique. It was found that exposure to pesticides and tobacco smoking had significant effects on aTL. Individuals occupationally exposed to complex mixtures of pesticides in tobacco fields and individuals who smoked had decreased aTL compared with the non-exposed group. TBARS and TEAC were significantly elevated in the exposed group. There were no significant differences in inorganic elements. There was no evidence of an influence of age, gender, consumption of alcoholic beverages, or intake of fruits and vegetables on aTL within the groups. In addition, years of work in the tobacco field in the exposed group did not influence any of the variables analyzed. Although further studies were needed, these results suggested differences in telomere maintenance in tobacco farmers compared with the control group, indicating that telomere length may be a good biomarker of occupational exposure.

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Section: Discussionmentioning

confidence: 99%

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

Kahl

Simon

Salvador

et al. 2015

Environ and Mol Mutagen

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“…As discussed earlier in this chapter, DNA damage in adulthood may originate in early life [98,101], as lifelong dietary patterns are established in childhood. Yet, most studies with regard to telomere length in children are conducted on the effects of environmental exposure and socioeconomic and psychological status [72,73,98,99,101,103].…”

Section: What Can Be Done To Help Maintain Telomere Length?mentioning

confidence: 95%

“…The impact of adverse exposure on telomere shortening starts at a very early developmental stage. Environmental exposure to lead in children appears to be associated with shorter telomeres [98], as prenatal exposure to toxic agents also seems to be a predictor of telomere imbalance. Neonatal umbilical cord blood showed a positive association between shortened fetal telomere length and smoking during pregnancy [99].…”

Section: Occupational and Environmental Exposuresmentioning

confidence: 99%

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Telomere Length and Its Relation to Human Health

Kahl¹,

Silva²

2016

Telomere - A Complex End of a Chromosome

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Telomeres are complex nucleotide sequences that cap the end of chromosomes from degradation, unwanted recombination-fusion, inappropriate activation of DNA damage response and play a critical role in cell division and chromosome stability. There is growing evidence that telomere stability can be affected by occupational and environmental exposure, as some of these factors have been correlated with increase in inflammation, oxidative stress, DNA damage, chromosome aberration, and epigenetic alterations. Both extremely short and long telomeres have been associated with neurodegenerative, cardiovascular diseases (CVD) and cancer risk. Occupational and environmental exposure to several synthetic and natural chemicals has been found to be associated with changes in telomere length, although the molecular mechanism is not fully understood. Telomeric DNA is relatively less capable of repair, resulting in accelerated shortening during the cell cycle and replicative senescence. It is recognized that diet plays an important role in telomere maintenance. Prevention of exposure to environmental and occupational hazards as well as psychological stressors can reduce the risk of telomere instability. This review provides a broad evaluation of the associated mechanism between human health and environmental and occupational exposure with telomere length, including recent findings and future perspectives.

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“…Stress may accelerate telomere shortening, and the length of telomeres is often considered to be a biomarker of chronic stress [23]. In children, telomere length has been linked to early adversity and psychological stress [24, 25], family violence [23, 26], lead exposure [27], and cigarette smoking [26], as well as zinc deficiency [28] and disturbances in the one carbon metabolism that occur during folate or B 12 deficiency [29]. In a pilot study with Nepalese children, we estimated the relative telomere length in 66 infants and found that the plasma methylmalonic acid (MMA) concentration was inversely associated with the telomere length (unpublished results, personal communication T. Strand).…”

Section: Introductionmentioning

confidence: 99%

The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

Strand

Ulak

Chandyo

et al. 2017

Trials

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BackgroundVitamin B12 deficiency is one of the most common micronutrient deficiencies and is associated with poor cognitive development and growth. Vitamin B12 is crucial for normal cell division and differentiation, and it is necessary for the development and myelination of the central nervous system. The aim of the present study is to measure the effect of daily supplementation of vitamin B12 on the neurodevelopment and growth of young children in Nepal.Methods/designWe are conducting an individually randomized, double-blind, placebo-controlled trial with 600 marginally stunted children 6–11 months old (length for age less than −1 z-score). Children are randomized to receive a lipid-based paste containing vitamin B12 or placebo daily for 12 months. The main outcomes are changes in growth (z-scores) and in neurodevelopment measured by the Bayley Scales of Infant and Toddler Development, Third Edition, from baseline until the end of the study.DiscussionIf vitamin B12 supplementation benefits early child development and growth, this will have consequences for dietary recommendations for malnourished children worldwide.Trial registrationsClinicalTrials.gov Identifier: NCT02272842. Registered on 21 October 2014.Universal Trial Number: U1111-1161-5187. Registered on 8 September 2014.Electronic supplementary materialThe online version of this article (doi:10.1186/s13063-017-1937-0) contains supplementary material, which is available to authorized users.

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Telomere length in children environmentally exposed to low-to-moderate levels of lead

Cited by 38 publications

References 72 publications

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

Telomere measurement in individuals occupationally exposed to pesticide mixtures in tobacco fields

Telomere Length and Its Relation to Human Health

The effect of vitamin B12 supplementation in Nepalese infants on growth and development: study protocol for a randomized controlled trial

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