Telomere Length Dynamics in Vascular Disease: A Review

Butt, H.Z.; Atturu, Gnaneswar; London, N. J. M.; Sayers, R.D.; Bown, Matthew J.

doi:10.1016/j.ejvs.2010.04.012

Cited by 83 publications

(50 citation statements)

References 69 publications

(72 reference statements)

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“…The first is elevated filling pressures from longstanding borderline to high blood pressure, Shorter telomere lengths have been shown to be associated with early ventricular stiffness and elevated filling pressures, 21 and also the development and progression of hypertension, peripheral vascular disease, and vascular-disease related complications. 22 A second mechanism is autonomic nervous system dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

et al. 2016

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“…18,19 LTL is also inversely associated with cardiovascular disease risk factors, including cigarette smoking, obesity, sedentary lifestyle, and an unhealthy lifestyle in general. 27 However, we lack studies on loss of telomere length and Htype hypertension.…”

Section: Discussionmentioning

confidence: 99%

DNA Methylation of Human Telomerase Reverse Transcriptase Associated With Leukocyte Telomere Length Shortening in Hyperhomocysteinemia-Type Hypertension in Humans and in a Rat Model

Zhang

Wen

Zhang

et al. 2014

Circ J

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Circulation Journal Official Journal of the Japanese Circulation Society http://www. j-circ.or.jp aging-related diseases. Particularly, clinical epidemiological studies and studies of telomerase-deficient mice have shown a direct link between telomere shortening and hypertension. 6 In addition, experimental evidence reveals that both elevated Hcy level and hypertension are related to DNA methylation of leukocytes and are associated with the burden of oxidative stress, inflammation, altered elasticity of the vascular wall, and renal function; all key contributors to age-dependent shortening of leukocyte telomere length (LTL). 7 Our previous in vivo and in vitro studies demonstrated that Hcy could promote the recruitment of methylation-sensitive transcription factors to demethylated promoters of atherosclerosis-related genes by reducing DNA methyltransferase 1 activity. 8, 9 The human telomerase reverse transcriptase (hTERT) gene might regulate telomerase activity and maintain telomere length by encoding the catalytic subunit of the telomerase holoenzyme. 5 The hTERT level is tightly regulated by DNA methssential hypertension (EH) is a complex disorder involving approximately one-third of the adult population worldwide. 1,2 Epidemiological studies have documented that aging as well as genetic and environmental factors such as physical inactivity, obesity, high sodium and low potassium diet, and alcohol consumption are associated with the development of hypertension. 3,4 In addition, dysregulated methionine metabolism leading to high plasma homocysteine (Hcy) levels (≥10 mmol/L), known as hyperhomocysteinemia-type EH (HHcy-EH), might play a role. 5 However, the mechanisms underlying HHcy-EH and its adverse complications remain unknown. Editorial p 1828Telomere dynamics (telomere length and its age-dependent shortening) provide valuable insights into the pathogenesis of Background: Elevated homocysteine (Hcy) levels might play a role in the development of essential hypertension (EH). Telomere dynamics provide valuable insight into the pathogenesis of age-related diseases. The contribution of Hcy to leukocyte telomere length (LTL) shortening in EH and the underlying mechanism was examined.

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“…[3][4][5] In particular, aging-related endothelial dysfunction would contribute to pathogenesis, maintenance and development of atherosclerosis. Endothelial dysfunction is the initial step of atherosclerosis and is involved in the development of atherosclerosis.…”

Section: Endothelial Dysfunction and Agingmentioning

confidence: 99%

“…1,2 Aging is associated with alterations of vascular structure and function through various pathways, including oxidative stress, cell senescence and inflammation. [3][4][5] In addition, the presence of hypertension accelerates aging-related alterations of vascular structure and function, particularly endothelial function. 6,7 Endothelial dysfunction is an early feature of atherosclerosis and vascular diseases in humans.…”

Section: Introductionmentioning

confidence: 99%

Endothelial dysfunction and hypertension in aging

2012

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Hypertension is one of the common diseases in the elderly. The prevalence of hypertension markedly increases with advancing age. Both aging and hypertension have a critical role in cardiovascular and cerebrovascular complications. Although aging and hypertension, either independently or collectively, impair endothelial function, aging and hypertension may have similar cascades for the pathogenesis and development of endothelial dysfunction. Nitric oxide (NO) has an important role in regulation of vascular tone. Decrease in NO bioavailability by endothelial dysfunction would lead to elevation of blood pressure. An imbalance of reduced production of NO or increased production of reactive oxygen species, mainly superoxide, may promote endothelial dysfunction. One possible mechanism by which the prevalence of hypertension is increased in relation to aging may be advancing endothelial dysfunction associated with aging through an increase in oxidative stress. In addition, endothelial cell senescence is also involved in aging-related endothelial dysfunction. In this review, we focus on recent findings and interactions between endothelial function, oxidative stress and hypertension in aging.

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Telomere Length Dynamics in Vascular Disease: A Review

Abstract: Multiple associations between short telomere length and vascular disease characterised by atherosclerosis suggest a possible link between telomere attrition and disease mechanisms. Further studies are warranted to validate and define the role of telomeres in vascular disease pathogenesis.

Cited by 83 publications

References 69 publications

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

Shortened telomere length is associated with paroxysmal atrial fibrillation among cardiovascular patients enrolled in the Intermountain Heart Collaborative Study

DNA Methylation of Human Telomerase Reverse Transcriptase Associated With Leukocyte Telomere Length Shortening in Hyperhomocysteinemia-Type Hypertension in Humans and in a Rat Model

Endothelial dysfunction and hypertension in aging

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