Telomere Length as a Biomarker and Potential Contributor of Heart Failure Progression

Silver, Elizabeth; Ras, Aleksandra; Cosgrove, C.; Sheiner, Patricia A.; Gluck, Jason; Wencker, Detlef; Statz, Cara

doi:10.1016/j.cardfail.2015.06.111

Cited by 1 publication

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“…Telomere shortening has been suggested to be susceptible to age-related cardiovascular diseases, including atherosclerosis and heart failure [5,7]. Many studies have shown that LTL predicts cardiovascular disease and all-cause mortality [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

“…The shortening of telomere length has been found to be common with age in the majority of tissues and cells; thus, it is often used as a biomarker of aging [4]. Research efforts have argued that leukocyte telomere length (LTL) shortening is related to a variety of cardiovascular diseases, including atherosclerosis, left ventricular hypertrophy, and heart failure, but the relevance to AF is still controversial [5][6][7]. In the Cardiovascular Health Study, researchers found no relationship between mean telomere length and AF in human atrial tissue [8].…”

Section: Introductionmentioning

confidence: 99%

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Mitochondrial Dysfunction Contributes to Aging‐Related Atrial Fibrillation

Liu

Bai

Dan

et al. 2021

Oxidative Medicine and Cellular Longevity

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The incidence of atrial fibrillation (AF) increases with age, and telomere length gradually shortens with age. However, whether telomere length is related to AF is still inconclusive, and the exact mechanism by which aging causes the increased incidence of AF is still unclear. We hypothesize that telomere length is correlated with aging-related AF and that mitochondrial dysfunction plays a role in this. This research recruited 96 elderly male patients with AF who were admitted to the Second Medical Center of Chinese PLA General Hospital from April to October 2018. After matching by age and gender, 96 non-AF elderly male patients who were admitted to the hospital for physical examination during the same period were selected as controls. Anthropometric, clinical, and laboratory analyses were performed on all subjects. The mitochondrial membrane potential (MMP) of peripheral blood leukocytes was detected as the indicator of mitochondrial function. Compared with the control group, the leukocyte telomere length (LTL) was significantly shorter ( P < 0.001 ), and the level of PGC-1α in serum was significantly lower in AF patients. Additionally, in subjects without any other diseases, the AF patients had lower MMP when compared with the control. Multivariate logistic regression confirmed that LTL (OR 0.365; 95% CI 0.235-0.568; P < 0.001 ) and serum PGC-1α (OR 0.993; 95% CI 0.988-0.997; P = 0.002 ) were inversely associated with the presence of AF. In addition, ROC analysis indicated the potential diagnostic value of LTL and serum PGC-1α with AUC values of 0.734 and 0.633, respectively. This research concludes that LTL and serum PGC-1α are inversely correlated with the occurrence of aging-related AF and that mitochondrial dysfunction plays a role in this.

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