Telomere length and type 2 diabetes in males, a premature aging syndrome

Murillo-Ortíz, Blanca; Albarrán-Tamayo, Froylán; Arenas‐Aranda, Diego; Benı́tez-Bribiesca, Luis; Malacara, Juan Manuel; Martı́nez-Garza, Sandra; Hernández-González, Martha Alicia; Solorio-Meza, Sergio; Garay‐Sevilla, Ma. Eugenia; Mora-Villalpando, Carmen

doi:10.3109/13685538.2011.593658

Cited by 51 publications

(43 citation statements)

References 29 publications

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“…9,33,34 Inflammatory markers, such as C-reactive protein (CRP) and interleukin-6, are independent predictors of insulin resistance, coronary artery disease and metabolic syndrome, 35,36 and have also been inversely associated with LTL in subjects aged 65 years or over. 6 Dietary patterns including fruits, vegetables, whole grains, fish and different types of fatty acids, are inversely associated with different inflammatory markers.…”

Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Männistö

et al. 2012

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Shorter leukocyte telomere length (LTL) is associated with several chronic diseases, but only a few studies have assessed the association between dietary factors and LTL. Our objective was to study the association between fats, fruits, vegetables and LTL in a cross-sectional study design. We hypothesized that intakes of fruits and vegetables would be positively associated with LTL and that intakes of fats, and especially saturated fatty acids (SFAs), would be negatively associated with LTL. SUBJECTS/METHODS: LTL was measured by quantitative real-time polymerase chain reaction in 1942 men and women aged 57-70 years from the Helsinki Birth Cohort Study. We assessed the whole diet by a validated semiquantitative 128-item food-frequency questionnaire. RESULTS: In general, there were only a few significant results. However, total fat and SFA intake (P ¼ 0.04 and 0.01, respectively) were inversely associated with LTL in men adjusting for age and energy intake. In women, vegetable intake was positively associated with LTL (P ¼ 0.05). Men consuming the most butter and least fruits had significantly shorter telomeres than those consuming the lowest amounts of butter and highest amounts of fruits (P ¼ 0.05). We found no association between LTL and body mass index, waist-hip ratio, smoking, physical activity or educational attainment. CONCLUSIONS: In this cross-sectional study of elderly men and women, there were only a few statistically significant effects of diet, but in general they support the hypothesis that fat and vegetable intakes were associated with LTL.

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Section: Discussionmentioning

confidence: 99%

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Männistö

et al. 2012

Eur J Clin Nutr

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“…В 2012 г. было показано, что про-грессирующее укорочение теломер с увеличением продолжительности СД2 может быть связано с па-раллельно увеличивающимся окислительным стрес-сом и хроническим воспалением [5]. Наши резуль-таты согласуются с данными ранее проведенных ис-следований.…”

Section: Discussionunclassified

“…Имеются данные, что длина теломер в лейкоцитах отражает длину теломер в стволовых клетках и соответствует их длине в эндотелиальных прогениторных клетках, что позволяет рассматривать данный параметр как биомаркер старения сосудов. Получены первые ука-зания на укорочение теломер у лиц с СД2 и нару-шенной толерантностью к глюкозе [5]. Укорочение теломер может быть связано с развитием СД2, ССЗ и старением сосудов [6].…”

Section: биология теломер у лиц с сд2unclassified

“…Повышенная воспали-тельная активность ускоряет укорочение теломер как за счет активации размножения клеток, так и за счет высвобождения АФК [9]. Прогрессирующее укорочение теломер с увеличением продолжитель-ности СД2 может быть связано с хроническим вос-палением и окислительным стрессом [5]. Взаимос-вязь активности теломеразы и хронического воспа-ления неоднозначна.…”

Section: биология теломер у лиц с сд2unclassified

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Telomere length, telomerase activity and mechanisms change in patients with type 2 diabetes mellitus

Браилова

Васильевна²,

Dudinskaya

et al. 2016

Probl Endokrinol (Mosk)

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Aim.To study the association of chronic inflammation, oxidative stress with telomere biology in people with type 2 diabetes mellitus (T2DM).Material and Methods.A total 50 patients with T2D and without cardiovascular disease (CVD) and 139 people from control group were included in the study. All subjects were measured for carbohydrate metabolism; oxidative stress (malondialdehyde (MDA)); inflammation (C-reactive protein — CRP, fibrinogen, interleukin-6); lymphocyte telomere length, telomerase activity.Results.In diabetic patients telomeres were shorter than in controls (9.59±0.54 and 9.76±0.47; p=0.031), telomerase activity was lower (0.47±0.40 and 0.62±0.36; p=0.039), inflammation (CRP, elevated fibrinogen) was higher. All patients were divided by telomere length. In T2DM group CRP was higher in patients with «short» telomeres (7.39±1.47 and 3.59±0.58 mg/L; p=0.02). There were no significant differences in the level of chronic inflammation and oxidative stress in ‘long’ telomeres group: CRP 3.59±0.58 and 3.66±0.50 mg/L (p=0.93), MDA 2.81±0.78 and 3.24±0.78 mmol/l (p=0.08). Diabetic patients in «short» telomeres group had greater chronic inflammation: CRP 7.39±1.47 and 4.03±0.62 mg/L (p=0.046), increased fibrinogen, 0.371 and 0.159 (p=0.022). All patients were divided by telomerase activity. Severity of chronic inflammation was greatest in T2DM and the «low» activity of telomerase. There were relationship between telomere length and CRP in T2DM patients (r=–0.40; p=0.004).Conclusions. Chronic inflammation and cell aging were more pronounced in patients with T2DM. However, despite diabetes, signs of chronic inflammation were minimal in patients with «long» telomeres compared to healthy people. Perhaps long telomeres protect diabetic patients from the damaging effect of chronic inflammation.

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“…В настоящее время получены первые данные, что для СД2 и нарушенной толерантности к глюкозе ха-рактерно ускоренное укорочение длины лимфоцитарных теломер [13,14]. Это может быть связано как с наруше-нием секреции инсулина, так и с развитием ИР.…”

Section: /2014unclassified

Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

Dudinskaya¹,

Tkacheva²,

Shestakova³

et al. 2014

Diabetes mellitus

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Telomere length and type 2 diabetes in males, a premature aging syndrome

Abstract: Telomere shortening increases with the duration of diabetes. The time of exhibition suggests in parallel that the progressive increase of inflammation and/or oxidative stress plays a direct role in telomere shortening.

Cited by 51 publications

References 29 publications

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Leukocyte telomere length and its relation to food and nutrient intake in an elderly population

Telomere length, telomerase activity and mechanisms change in patients with type 2 diabetes mellitus

Telomere length and vascular wall in patients with Type 2 Diabetes Mellitus

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