Telomere length and obesity

Zannolli, Raffaella; Mohn, Angelika; Buoni, Sabrina; Pietrobelli, Angelo; Messina, Mario; Chiarelli, Francesco; Miracco, Clelia

doi:10.1111/j.1651-2227.2008.00783.x

Cited by 87 publications

(93 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6,7 Some studies demonstrate an association between adiposity and telomere length. For instance, Valdes et al 5 found that obese white women had shorter telomeres than lean white women, whereas Zanolli et al 8 found shorter telomere lengths in the obese when evaluating 23 white adults. An inverse correlation has also been described between leptin, a polypeptide produced primarily in white adipose tissue, and telomere length in premenopausal, but not postmenopausal, women.…”

Section: Introductionmentioning

confidence: 99%

Telomere length and adiposity in a racially diverse sample

et al. 2009

View full text Add to dashboard Cite

Objective: To evaluate the cross-sectional relationship of anthropometric measures (body mass index (BMI) and visceral fat and the adipokines leptin and adiponectin) with telomere length in a racially diverse sample. Design: Cross-sectional study of participants recruited from a health science university. Subjects: Participants include 317 men and women aged 40-64 years without diagnosed diabetes, cardiovascular disease (defined as coronary heart disease or stroke/transient ischemic attack) or cancer. Results: Study participants were 54.9% female, 58% non-Hispanic white (NHW) and 42% non-Hispanic Black (NHB). Of the sample, 76% were either overweight or obese. Linear regressions showed no association between the anthropometric measures (BMI (kg m À2 ), visceral fat (cm 2 ), adiponectin (mg ml À1 ), leptin (ng ml À1 ) or adiponectin to leptin ratio (mg ng À1 )) assessed in a continuous manner and telomere length assay ratio, either for the whole sample or when stratified by race or by gender. Conclusion: This study finds no linear associations between telomere length and several measures of obesity in a sample of NHB and NHW men and women. Further studies are needed to identify factors that influence telomere length in diverse populations. International Journal of Obesity (2010) 34, 261-265; doi:10.1038/ijo.2009 published online 22 September 2009 Keywords: racial differences; telomere length; adiposity; adiponectin BackgroundTelomeres consist of TTAGGG tandem repeats found at the ends of chromosomes that protect them from degradation and end-to-end fusion. They shorten as somatic cells replicate. This shortening ultimately leads to a loss of replicative capacity. Thus, telomeres may be uniquely useful in identifying biological aging and disease risk as they represent an individual's inherited predisposition to cell senescence as well as exposure to environmental stressors, such as low socioeconomic status, smoking and life stress. [1][2][3][4][5] On the basis of the known association between adiposity and systemic inflammation and oxidative stress, telomere length could be expected to be decreased in obese individuals, but conflicting evidence exists. The few studies that have evaluated telomere length in minority samples show racial differences in telomere length, although they also present conflicting results. Some studies have shown that minorities have longer telomere length, although they suggest quicker shortening in minorities. 14,15 Another study demonstrated that blacks and Hispanics had shorter telomeres than whites. 16 One possible reason for these differences could be a differential impact of adiposity on telomere length by race, similar to the differential impact of adiposity on mortality that has been previously demonstrated between Whites and Blacks. In these studies, the association between being overweight and mortality appears to be weaker in Blacks than Whites. 17,18 To further describe the relationship between adiposity and telomere length, we will evaluate the relationship between anthropo...

show abstract

Section: Introductionmentioning

confidence: 99%

Telomere length and adiposity in a racially diverse sample

et al. 2009

View full text Add to dashboard Cite

show abstract

“…Both are states of heightened oxidative stress, which increases the rate of telomere erosion per replication, and inflammation, which enhances WBC turnover [9,10,98,99]. Obese adults have shorter telomeres than their normal-weight counterparts, while this phenomenon is not present in childhood [98]. Together, these processes might accelerate telomere erosion with age [98,99].…”

Section: Clinical Disorders Associated With Age-dependent Telomere Lomentioning

confidence: 99%

“…Obese adults have shorter telomeres than their normal-weight counterparts, while this phenomenon is not present in childhood [98]. Together, these processes might accelerate telomere erosion with age [98,99]. Monocyte telomere shortening in type 2 diabetes could be due to increased oxidative DNA damage to monocyte precursors during cell division [102].…”

Section: Clinical Disorders Associated With Age-dependent Telomere Lomentioning

confidence: 99%

“…Shorter TL in leukocytes has been associated cross-sectionally with CVD and its risk factors, including pulse pressure and vascular aging [1,86,[95][96][97], obesity [87,98,99], vascular dementia [88,100], diabetes [98,[101][102][103][104], coronary artery disease (CAD) [1,105,106], myocardial infarction (MI) [107] although not in all studies [108], and cellular turnover and exposure to oxidative and inflammatory damage in chronic obstructive pulmonary disease (COPD) [109]. Leukocyte TL correlates with a subset of measures of cognitive performance, suggesting that it might be a biomarker of cognitive aging in women before the onset of dementia [110].…”

Section: Clinical Disorders Associated With Age-dependent Telomere Lomentioning

confidence: 99%

See 1 more Smart Citation

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Babizhayev¹,

Vishnyakova

Yegorov

2014

Journal of Basic and Clinical Physiology and Pharmacology

View full text Add to dashboard Cite

It has been documented that telomere-associated cellular senescence may contribute to certain age-related disorders, and telomere length (TL) may be an informative biomarker of healthy aging. Hormone-brain-aging behaviormodulated telomere dynamics and changes in telomerase activity are consistent elements of cellular alterations associated with changes in proliferative state, and these processes are consequently considered as the new therapeutic drug targets for physiological control with advanced drug delivery and nutritional formulations. We raise and support a therapeutic concept of using nonhydrolyzed forms of naturally occurring neuron-specific imidazole dipeptide-based compounds carnosine and carcinine, making it clinically possible that slowing down the rate of telomere shortening could slow down the human aging process in specific tissues where proliferative senescence is known to occur, with the demonstrated evidence of telomere shortening that appeared to be a hallmark of oxidative stress and disease. Carnosine released from skeletal muscle during exercise may be transported into the hypothalamic tuberomammillary nucleus (TMN) histamine neurons and hydrolyzed. The resulting L-histidine may subsequently be converted into histamine, which could be responsible for the effects of carnosine on neurotransmission and hormone-like antiaging physiological function. The preliminary longitudinal studies of elderly individuals suggest that longer telomeres are associated with better survival, and an advanced oral nutritional support with nonhydrolyzed carnosine (or carcinine and patented compositions thereof) is a useful therapeutic tool for a critical TL maintenance that may fundamentally be applied in the treatment of age-related sight-threatening eye disorders, prolonged life expectancy, increased survival and chronological age of an organism in health control, smoking behavior, and disease."Our pleasures were simple-they included survival." -Dwight D. Eisenhower, 34th President of the United States, 1953States, -1961

show abstract

“…(Londono-Vallejo, 2001), ( ) (Roux , 2009), ( ) (Benetos , 2001;Cherif , 2003) (heterogeneous) , (von Zglinicki, 2000;Epel , 2004;Zannolli , 2008). , (Frenck , 1998;Monaghan Haussmann, 2006;, 2008;, 2008 Brummendorf , 2002), (Hall , 2004;Pauliny , 2006;) .…”

mentioning

confidence: 99%

Cattle Age Prediction by Leukocytes Telomere Quantification

Choi¹,

Kim²,

Choe³

et al. 2010

Journal of Animal Science and Technology

View full text Add to dashboard Cite

Telomeres at the end of chromosomes consist of tandem repeats of (TTAGGG)n DNA sequence and associated proteins. Telomeres have the essential functions in chromosome stability and genome integrity and are hence related to cell senescence and cancer. This study was carried out to quantify the amount of telomeric DNA and establish age prediction equations by using the quantity of telomeric DNA for cattle. Analysis of the telomere quantity of the lymphocytes was performed at different age, across breeds and between different sexes of cattle. We quantified the amount of telomeric DNA by the Q-FISH technique using the telomeric DNA probe in 460 cattle at age of 1~166 months in Korean Cattle and Holstein breeds. In results, we found that the amount of telomeric DNA decreased gradually with age. The amount of telomeric DNA of Korean Cattle was significantly higher than that of Holstein breed (P<0.01). In addition, the amount of telomeric DNA in male was significantly higher than that in female (P<0.01). Using the relationship between age and the amount of telomeric DNA in cattle, age predicting equations were established as a result of regression analysis. Because sex and breeds influenced telomeric DNA quantity, the age prediction equations were estimated separately in Korean Cattle females and Holstein females. The regression equations were Ŷ = 38.102X 0.8379) in Holstein females, where the X was quantity of telomeric DNA and Y was predicted age in months. These equations predicted the age of cattle with high significance and accuracy and have high R square values. Thus, it could be possible to scientifically predict the age using the above equations for Korean Cattle and Holstein females.

show abstract

Telomere length and obesity

Abstract: Obese adults have shorter telomeres than their normal-weight counterparts, while this phenomenon is not present in childhood.

Cited by 87 publications

References 13 publications

Telomere length and adiposity in a racially diverse sample

Telomere length and adiposity in a racially diverse sample

Hormone-brain-aging relationships, broadly reactive with imidazole-containing dipeptides: targeting of telomere attrition as an aging biomarker and dynamic telomerase activity flirting

Cattle Age Prediction by Leukocytes Telomere Quantification

Contact Info

Product

Resources

About