Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Nguyen, Minh Thien; Saffery, Richard; Burgner, David; Lycett, Kate; Vryer, Regan; Grobler, Anneke; Dwyer, Terence; Ranganathan, Sarath; Wake, Melissa

doi:10.1002/ppul.24489

Cited by 6 publications

(6 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings are in contrast with the only other study of leukocyte TL and lung function in children, which reported no association between TL and any spirometry index of lung function among 11-year-old children [ 24 ]. However, that study took place in a high-income setting (Australia), measured TL in all blood cells, and included only HIV-uninfected children, making a comparison between the 2 studies difficult.…”

Section: Discussioncontrasting

confidence: 99%

“…In pediatric populations in whom tobacco smoking is a less likely confounder, little is known regarding CLD and TL (both HIV and non-HIV). A large study of participants without HIV suggested a moderate association between shorter leukocyte TL and reduced lung function in adults, but not in children [ 24 ]. Knowing that uncontrolled HIV is associated with shorter leukocyte TL and that HIV causes chronic inflammation, which could negatively impact lung health, we hypothesized that C-PHIV with CLD would show shorter TL than non-CLD or non-HIV peers.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe

Ajaykumar

Wong

Yindom

et al. 2020

Clinical Infectious Diseases

View full text Add to dashboard Cite

Background Chronic lung disease (CLD) has been reported among African children with perinatally-acquired HIV infection (C-PHIV), despite combination antiretroviral therapy (cART). In adults, shorter telomere length (TL) has been reported in association with both CLD and HIV. As little is known in children, our objective was to compare TL in HIV+ (cART-naïve or treated) and HIV-negative children with and without CLD. Methods Participants included Zimbabwean C-PHIV, aged 6-16, who were either newly diagnosed and cART-naïve, or on cART for >6 months, and HIV-negative controls of similar age and sex. Packed blood cell (granulocyte) TL from 621 children were compared cross-sectionally between groups. For a subset of newly diagnosed C-PHIV, changes in TL following cART initiation was evaluated. Results C-PHIV had shorter granulocyte TL compared to uninfected peers, regardless of cART. Among 255 C-PHIV without CLD, TL was shorter in cART-naïve participants. In multivariable analyses adjusted for age, sex, CLD, and HIV/cART status, shorter TL was independently associated with older age, being HIV+, and having reduced forced vital capacity (FVC). Lastly, cART initiation increased TL. Conclusions In this cohort, C-PHIV and those with reduced FVC have shorter granulocyte TL, possibly the result of increased immune activation and cellular turnover due to long-standing HIV infection with delayed cART initiation.

show abstract

Section: Discussioncontrasting

confidence: 99%

mentioning

confidence: 99%

Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe

Ajaykumar

Wong

Yindom

et al. 2020

Clinical Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…Second, paternal age has been shown to play a role in the vertical transmission of telomere length [32][33][34]. Previous reports have provided evidence that lung function in children and adults is associated with telomere length [35][36][37][38]. Therefore, it may be speculated that advanced paternal age may affect offspring's lung function through alterations of telomere length.…”

Section: Resultsmentioning

confidence: 99%

Association of advanced paternal age with lung function at school age

Gau

Lee

et al. 2022

Respir Res

View full text Add to dashboard Cite

Background Epidemiological studies suggest that advanced paternal age impact offspring health, but its impact on respiratory health is unclear. This study aimed to investigate the association of paternal age with lung function and fraction of exhaled nitric oxide (FeNO) in children. Methods We analyzed data from 1330 single-born children (576 girls, 43.3%; mean age, 6.4 years), who participated in the Longitudinal Investigation of Global Health in Taiwanese Schoolchildren (LIGHTS) cohort and received measurements of lung function and FeNO at 6-year follow-up visits. Covariate-adjusted regression analyses were applied. Results Every 5-year increase in paternal age at birth was associated with 0.51% decrease in FEV1/FVC ratio (95% CI − 0.86 to − 0.15; p = 0.005) and 19.86 mL/s decrease in FEF75 (95% CI: − 34.07 to − 5.65; p = 0.006). Stratified analyses revealed that increasing paternal age at birth was associated with decreasing FEV1/FVC ratio and FEF75 only among children with prenatal exposure to environmental tobacco smoke (ETS) or not being breastfed. Sensitivity analyses using paternal age as a categorical variable found decreasing FEV1/FVC ratio and FEF75 in the groups of paternal age 35–39 and ≥ 40 years. There was no association of paternal age at birth with FeNO. Conclusion Our findings provide novel evidence linking advanced paternal age at birth with decreasing lung function in children at school age. Children with prenatal exposure to ETS or not being breastfed are more vulnerable to the adverse effect of advanced paternal age on childhood lung function. Further studies are warranted to confirm this novel adverse effect of advanced paternal age.

show abstract

“…The fact that oral disposition index (oDI), the only dynamic measure of beta-cell function which controls for prevailing insulin resistance, was not associated with children’s LTL, despite the many associations between pancreatic traits and children’s LTL, may suggest the associations of LTL with beta-cell function were perhaps driven by the association between LTL and insulin resistance. Several reports have observed that LTL may be associated differently with traits in children versus in adulthood [ 35 – 37 ]. This and our observations highlight the dynamics of LTL across life stages and stress the importance of studies of LTL at an early age.…”

Section: Discussionmentioning

confidence: 99%

Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Wong

Cheng

Lim

et al. 2022

BMC Med

View full text Add to dashboard Cite

Background Leukocyte telomere length (LTL) is suggested to be a biomarker of biological age and reported to be associated with metabolic diseases such as type 2 diabetes. Glucose metabolic traits including glucose and insulin levels have been reported to be associated with LTL in adulthood. However, there is relatively little research focusing on children’s LTL and the association with prenatal exposures. This study investigates the relationship between maternal and offspring glucose metabolism with offspring LTL in early life. Methods This study included 882 mother-child pairs from the HAPO Hong Kong Field Centre, with children evaluated at age 7.0 ± 0.4 (mean ± SD) years. Glucose metabolic traits including maternal post-load glucose during pregnancy, children’s glucose and insulin levels, and their derived indices at follow-up were measured or calculated. Offspring LTL was assessed using real-time polymerase chain reaction. Results Sex- and age-adjusted children’s LTL was found to be associated with children’s HOMA-IR (β=−0.046 ± 0.016, p=0.005). Interestingly, both children’s and maternal post-load glucose levels were positively associated with children’s LTL. However, negative associations were observed between children’s LTL and children’s OGTT insulin levels. In addition, the LTL in females was more strongly associated with pancreatic beta-cell function whilst LTL in males was more strongly associated with OGTT glucose levels. Conclusions Our findings suggest a close association between maternal and offspring glucose metabolic traits with early life LTL, with the offspring sex as an important modifier of the disparate relationships in insulin production and response.

show abstract

Telomere length and lung function in a population‐based cohort of children and mid‐life adults

Cited by 6 publications

References 36 publications

Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe

Shorter Granulocyte Telomeres Among Children and Adolescents With Perinatally Acquired Human Immunodeficiency Virus Infection and Chronic Lung Disease in Zimbabwe

Association of advanced paternal age with lung function at school age

Early emergence of sexual dimorphism in offspring leukocyte telomere length was associated with maternal and children’s glucose metabolism—a longitudinal study

Contact Info

Product

Resources

About