Telomere Length and Frailty: The Helsinki Birth Cohort Study

Haapanen, Markus J; Perälä, Mia-Maria; Salonen, Minna K.; Guzzardi, Maria Angela; Iozzo, Patricia; Kajantie, Eero; Rantanen, Taina; Simonen, Mika; Pohjolainen, Pertti; Eriksson, Johan G.; Bonsdorff, Mikaela von

doi:10.1016/j.jamda.2018.05.011

Cited by 34 publications

(15 citation statements)

References 41 publications

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“…Telomere shortening was more significant in our cohort than in other nontransplant populations, where telomere attrition is typically measured over years or decades rather than months [32]. Similarly to large nontransplant cohorts, however, approximately 20% of recipients showed a significant increase in telomere length over time [33].…”

Section: Discussionmentioning

confidence: 56%

Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival

et al. 2020

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Patients with short telomeres and interstitial lung disease may have decreased chronic lung allograft dysfunction (CLAD)-free survival following lung transplantation. The relationship between post-transplant telomere length and outcomes following lung transplantation has not been characterised among all recipients, regardless of native lung disease.This was a single-centre prospective cohort study. Consenting transplant recipients had their telomere length measured using quantitative real-time PCR assays on peripheral blood collected at the time of surveillance bronchoscopy. We assessed the association between early post-transplant telomere length (as measured in the first 100 days) and CLAD-free survival, time to clinically significant leukopenia, cytomegalovirus (CMV) viraemia, chronic kidney disease, and acute cellular rejection. We also assessed the association between rate of telomere shortening and CLAD-free survival.Telomere lengths were available for 98 out of 215 (45.6%) recipients who underwent lung transplant during the study period (median measurement per patient=2 (interquartile range, 1–3)). Shorter telomere length was associated with decreased CLAD-free survival (hazard ratio (HR)=1.24; 95% CI=1.03–1.48; p=0.02), leukopenia requiring granulocyte colony-stimulating factor (HR=1.17, 95% CI=1.01–1.35, p=0.03), and CMV viraemia among CMV-mismatch recipients (HR=4.04, 95% CI=1.05–15.5, p=0.04). Telomere length was not associated with acute cellular rejection or chronic kidney disease. Recipients with more rapid loss in telomere length (defined as the highest tertile of telomere shortening) did not have worse subsequent CLAD-free survival than those without rapid loss (HR=1.38, 95% CI=0.27–7.01, p=0.70).Shorter early post-transplant telomere length is associated with decreased CLAD-free survival and clinically significant leukopenia in lung transplant recipients, regardless of native lung disease.

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Section: Discussionmentioning

confidence: 56%

Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival

et al. 2020

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“…Some studies have also assessed the association between telomere length and frailty. Our earlier findings from the Helsinki Birth Cohort Study showed an inverse association between telomere length and risk of frailty (Haapanen et al, 2018). In contrast, a meta-analysis consisting of 3268 participants found no association between the two variables (Zhou et al, 2018).…”

Section: Discussionmentioning

confidence: 63%

Telomere length and physical performance among older people—The Helsinki Birth Cohort Study

Astrom

Bonsdorff

Perala

et al. 2019

Mechanisms of Ageing and Development

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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“…The presence of two X-chromosomes may confer a survival and/or ageing advantage due to selective chromosome inactivation (87). Longer telomeres and slower shortening processes may contribute to female longevity (88).…”

Section: Geneticmentioning

confidence: 99%

“…More recently, researchers have considered telomeres in relationship to the sex-frailty gap. Even though male and female telomere lengths are equal at birth, telomeres are not only longer in adult females than adult males but also shorten more slowly in females (88,119). Proposed mechanisms for this sex difference include potential influence by sex hormones on telomerase activity as well as protective effects of oestrogens against oxidative stress (119).…”

Section: Genetic Factorsmentioning

confidence: 99%

Sex differences in frailty: the Frailty Index and the male-female health-survival paradox

Gordon¹

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This publication is a 'highly cited paper' (with 62 citations to date) and is placed in the top 1% of papers in the field of Clinical Medicine in 2017 (Scopus 2019). This manuscript is incorporated into Chapter 2.. Author Contribution E Gordon (candidate) Systematic review and data collection (100%) Data analysis (25%) Data interpretation (100%) Wrote and edited manuscript (80%) Response to reviewers' comments (100%) N Peel Edited manuscript (5%) M Samanta Data analysis (75%) O Theou

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Telomere Length and Frailty: The Helsinki Birth Cohort Study

Abstract: Shorter relative LTL was associated with frailty in cross-sectional and longitudinal analyses, but telomere shortening was not, suggesting that short LTL may be a biomarker of frailty.

Cited by 34 publications

References 41 publications

Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival

Shorter telomere length following lung transplantation is associated with clinically significant leukopenia and decreased chronic lung allograft dysfunction-free survival

Telomere length and physical performance among older people—The Helsinki Birth Cohort Study

Sex differences in frailty: the Frailty Index and the male-female health-survival paradox

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