Telomere Length and Aging

Muzumdar, Radhika; Atzmon, Gil

doi:10.5772/53227

Cited by 7 publications

(8 citation statements)

References 140 publications

(117 reference statements)

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“…Bivariate analysis in the present sample revealed a significant positive relationship between religiosity and TL, consistent with previous research in the United States (Hill et al, 2016;Koenig et al, 2016). As expected, age was significantly and inversely correlated with TL, as many previous studies have reported (Delgado et al, 2017;Muzumdar & Atzmon, 2012).…”

Section: Discussionsupporting

confidence: 92%

Religiosity and Telomere Length: Moderating Effect of Religiosity on the Relationship Between High-Risk Polymorphisms of the Apolipoprotein E and TOMM40 Gene and Telomere Length

Wang

Koenig

et al. 2019

J Appl Gerontol

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Objective: The current study seeks to examine the relationship between religiosity and telomere length (TL) in an older Chinese Muslim sample and to explore the moderating effect of religiosity on the relationship between high-risk polymorphisms and TL. Methods: A cross-sectional study of 1,692 community-dwelling adults aged 55 or older was conducted. Apolipoprotein E and TOMM40 (rs2075650) gene polymorphisms and TL were determined using standard procedures. Ordinal logistic regression was used to examine the associations. Results: Religiosity was significantly and positively related to TL. A significant interaction emerged between religiosity and the rs2075650 G polymorphism in predicting TL. Stratified multivariate analyses demonstrated that the relationship between the rs2075650 G state and TL was particularly strong among those who were more religious, as hypothesized. Conclusion: The findings revealed that religiosity may influence cellular aging in part by modifying the effect that high-risk genes have on increasing vulnerability to dementia and cognitive impairment.

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Section: Discussionsupporting

confidence: 92%

Religiosity and Telomere Length: Moderating Effect of Religiosity on the Relationship Between High-Risk Polymorphisms of the Apolipoprotein E and TOMM40 Gene and Telomere Length

Wang

Koenig

et al. 2019

J Appl Gerontol

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“…Telomeres are repeated DNA sequences located at the ends of chromosomes and exist to maintain DNA integrity during cellular replication; chromosome ends tend to shorten with replication, and the repeat region protects against the loss of important gene sequences because loss of repeats can be tolerated (4). As such, telomeres shorten naturally with age as repeats are lost during replication cycles (5).…”

Section: Introductionmentioning

confidence: 99%

Telomere length is greater in ALS than in controls: a whole genome sequencing study

Khleifat

Iacoangeli

Shatunov

et al. 2019

Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

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Background: Amyotrophic lateral sclerosis is a neurodegenerative disease of motor neurons resulting in progressive paralysis and death, typically within 3–5 years. Although the heritability of ALS is about 60%, only about 11% is explained by common gene variants, suggesting that other forms of genetic variation are important. Telomeres maintain DNA integrity during cellular replication and shorten naturally with age. Gender and age are risk factors for ALS and also associated with telomere length. We therefore investigated telomere length in ALS. Methods: We estimated telomere length by applying a bioinformatics analysis to whole genome sequence data of leukocyte-derived DNA from people with ALS and age and gender-matched matched controls in a UK population. We tested the association of telomere length with ALS and ALS survival. Results: There were 1241 people with ALS and 335 controls. The median age for ALS was 62.5 years and for controls, 60.1 years, with a male–female ratio of 62:38. Accounting for age and sex, there was a 9% increase of telomere length in ALS compared to matched controls. Those with longer telomeres had a 16% increase in median survival. Of nine SNPs associated with telomere length, two were also associated with ALS: rs8105767 near the ZNF208 gene ( p = 1.29 × 10 −4 ) and rs6772228 ( p = 0.001), which is in an intron for the PXK gene. Conclusions: Longer telomeres in leukocyte-derived DNA are associated with ALS, and with increased survival in those with ALS.

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“…Future research could validate the subjective health perceptions by considering biological indicators of health, such as telomere length. Telomeres are DNA caps located at the end of chromosomes, and they protect chromosomes from deterioration (Muzumdar and Atzmon, 2012). As individuals age, the length of telomeres decreases.…”

Section: Limitationsmentioning

confidence: 99%

Perceptions of control and improved psychological, physical, and social functioning in postmenopausal women

Vargas

Mahalingam

2018

J Health Psychol

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Throughout life, social messages about women's bodies put them at greater risk of specific psychological health conditions than men; yet little is known about what psychological factors can help promote mental health in older women. In this study, we examine how perceptions of control relate to perceptions of psychological health, in addition to physical health, and social functioning in a sample of postmenopausal women. Results suggest that increased perceptions of control relate to improved perceptions of health via a reduction in negative affect. Implications for promoting health and reducing gendered mental health disparities are discussed.

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Telomere Length and Aging

Cited by 7 publications

References 140 publications

Religiosity and Telomere Length: Moderating Effect of Religiosity on the Relationship Between High-Risk Polymorphisms of the Apolipoprotein E and TOMM40 Gene and Telomere Length

Religiosity and Telomere Length: Moderating Effect of Religiosity on the Relationship Between High-Risk Polymorphisms of the Apolipoprotein E and TOMM40 Gene and Telomere Length

Telomere length is greater in ALS than in controls: a whole genome sequencing study

Perceptions of control and improved psychological, physical, and social functioning in postmenopausal women

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