Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia

Sukenik-Halevy, Rivka; Amiel, Aliza; Kidron, Dvora; Liberman, Meytal; Ganor-Paz, Yael; Biron‐Shental, Tal

doi:10.1016/j.ajog.2015.08.050

Cited by 46 publications

(49 citation statements)

References 40 publications

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“…Altered placental aging has been described in several obstetric complications 23 including stillbirth 24,25 , spontaneous preterm labor [26][27][28] , poorly controlled maternal diabetes 29 , pre-eclampsia and FGR 30,31 . Previous studies in placentas of pregnancies complicated by FGR showed markers of placental aging, including shorter telomeres, telomerase activity suppression [32][33][34] and increased apoptosis mediated by the p53 pathway [35][36][37] .…”

Section: Introductionmentioning

confidence: 99%

Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses

Paulés

Dantas

Miranda

et al. 2019

Ultrasound in Obstet & Gyne

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Section: Introductionmentioning

confidence: 99%

Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses

Paulés

Dantas

Miranda

et al. 2019

Ultrasound in Obstet & Gyne

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“…The adverse intrauterine environment during pregnancy is caused by factors like psychosocial risk issues, lack of social support, low socioeconomic status, and childhood trauma [19,20]. Association to the telomere and fetal programming and gene expression modifications has also been found linked with pre-eclampsia [21], intrauterine growth restriction (IUGR) [22], oxidative and nitrosative stress, and hypoxia [23,24].…”

Section: Introductionmentioning

confidence: 99%

Telomere reprogramming during fetal life in low socioeconomic mothers

Farrukh

Baig

Hussain

et al. 2019

Egypt J Med Hum Genet

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Background: Relative telomere length (RTL), the biological chronometer, varies considerably among individuals under the influence of multiple risk factors such as socioeconomic status (SES). It is anticipated that during fetal life, telomeres undergo reprogramming. The purpose of this study is to find the association between SES and telomere length of mother-newborn and genetic remodeling that occurs during fetal life. Results: The mean telomere/single gene copy (T/S) ratio and RTL (base pairs) among 250 mother-newborn dyads were higher in cord blood of newborns (1.18 ± 0.23) (6765 ± 1350 bp) (95% confidence level) compared to maternal blood (1.13 ± 0.18) (6432 ± 1350 bp) of all SES of the Pakistani population. A positive association (r = 0.396, p < 0.05) (F (2,238) = 9.229, p < 0.05) was found between maternal and newborn telomere length by using Spearman's correlation and regression analyses. Calculated RTL by Kruskal Wallis was found significant in low SES maternal and cord blood (5916 ± 754-6214 ± 596) compared to high SES maternal and cord blood (6818 ± 1248-7471 ± 1851). Conclusion: Significantly longer RTL in cord blood than maternal blood was observed in the targeted Pakistani population, including the low socioeconomic group highlighting fetal telomere reprogramming. High education appears to have a strong determining factor for longer RTL.

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“…fusion and aggregation of telomeric DNA. 1,38,39 Telomere length is regulated by the enzyme telomerase, a specific reverse transcriptase, capable of adding telomeric repeats to the ends of the chromosome. 40 Telomerase consists of a catalytic protein component, telomerase reverse transcriptase (TERT) and an RNA template component, tel-…”

Section: Cellular Senescence and Ageingmentioning

confidence: 99%

Oxidative stress, placental ageing‐related pathologies and adverse pregnancy outcomes

Sultana

Maiti

Aitken

et al. 2017

American J Rep Immunol

210

196

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Oxidative stress (OS), an imbalance between free radical generation and antioxidant defence, is recognized as a key factor in the pathogenesis of adverse pregnancy outcomes. Although OS is a common future of normal pregnancy, persistent, overwhelming OS leads to consumption and decline of antioxidants, affecting placental antioxidant capacity and reducing systems. The accumulation of OS causes damage to lipids, proteins and DNA in the placental tissue that induces a form of accelerated ageing.Premature ageing of the placenta is associated with placental insufficiency that prevents the organ meeting the needs of the foetus, and as a consequence, the viability of the foetus is compromised. This review summarizes the literature regarding the role of OS and premature placental ageing in the pathophysiology of pregnancy complications. K E Y W O R D Sintrauterine growth restriction, oxidative stress, placental ageing, pre-eclampsia, preterm birth, senescence, stillbirth | INTRODUCTIONAll living organisms have limited life cycles, and ageing is part of that life cycle. Each organ within an organism also exhibits ageing-related changes; the placenta is no exception. The placenta, a specialized organ formed during pregnancy, grows throughout gestation, performs multiple functions, including endocrine regulation and nourishment of the foetus, 1 but also ages and is discarded at the end of pregnancy, while the foetus may live for another hundred years. So placental ageing is a normal physiologic phenomenon. 2 However, there are likely to be some placentas which show signs of ageing earlier than others, in the same way as some individuals age more quickly than others. Premature ageing and degenerative changes in the placenta may reduce the functional capacity of the placenta and lead to abnormal pregnancy outcomes. The placenta is the primary organ for transferring nutrients from the mother to the foetus, so growth and function of the placenta are precisely regulated and coordinated to ensure the optimal growth and development of the foetus. The placenta exchanges nutrients, for example oxygen, amino acids, carbohydrates, minerals and waste products, for example carbon dioxide between the maternal and foetal circulatory systems. 3 It releases hormones into both the maternal and foetal circulations to affect uterine function, maternal metabolism, foetal growth and development. Moreover, it metabolizes some substances and can release metabolic products into both foetal and maternal circulations. The placenta can help to protect the foetus against certain xenobiotic molecules, infections and maternal diseases. Therefore, the adequate function of this organ is crucial for a normal physiologic gestational process and a healthy baby as a final outcome.In this review, we focus on the role of OS in the pathophysiology of pregnancy complications, beginning with a brief overview of placental development at different stages of gestation. We then discuss the biochemical markers of ageing and OS-induced placental ageing.Finally, we disc...

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Telomere homeostasis in trophoblasts and in cord blood cells from pregnancies complicated with preeclampsia

Cited by 46 publications

References 40 publications

Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses

Premature placental aging in term small‐for‐gestational‐age and growth‐restricted fetuses

Telomere reprogramming during fetal life in low socioeconomic mothers

Oxidative stress, placental ageing‐related pathologies and adverse pregnancy outcomes

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