Telomere biology: Rationale for diagnostics and therapeutics in cancer

Rousseau, Philippe; Autexier, Chantal

doi:10.1080/15476286.2015.1081329

Cited by 25 publications

(23 citation statements)

References 57 publications

(45 reference statements)

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“…Consequently, the benefits of telomerase inhibition depend on treatment duration, proliferation rate, and initial telomere lengths 169 . Thus, telomerase inhibition might be more effective in highly proliferative cancers or cancers with exceptionally short telomeres.…”

Section: Clinical Relevancementioning

confidence: 99%

Telomeres and telomerase in prostate cancer development and therapy

Graham

Meeker

2017

Nat Rev Urol

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Aberrations in telomere biology are among the earliest events in prostate cancer tumorigenesis and continue during tumour progression. Substantial telomere shortening occurs in prostate cancer cells and high-grade prostatic intraepithelial neoplasia. Not all mechanisms of telomere shortening are understood, but oxidative stress from local inflammation might accelerate prostatic telomere loss. Critically short telomeres can drive the accumulation of tumour-promoting genomic alterations; however, continued telomere erosion is unsustainable and must be mitigated to ensure cancer cell survival and unlimited replication potential. Prostate cancers predominantly maintain telomeres by activating telomerase, but alternative mechanisms of telomere extension can occur in metastatic disease. Telomerase activity and telomere length assessment might be useful in prostate cancer diagnosis and prognosis. Telomere shortening in normal stromal cells has been associated with prostate cancer, whereas variable telomere lengths in prostate cancer cells and telomere shortening in cancer-associated stromal cells correlated with lethal disease. Single-agent telomerase-targeted treatments for solid cancers were ineffective in clinical trials but have not been investigated in prostate cancer and might be useful in combination with established regimens. Telomere-directed strategies have not been explored as extensively. Telomere deprotection strategies have the advantage of being effective in both telomerase-dependent and telomerase-independent cancers. Disruption of androgen receptor function in prostate cancer cells results in telomere dysfunction, indicating telomeres and telomerase as potential therapeutic targets in prostate cancer.

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Section: Clinical Relevancementioning

confidence: 99%

Telomeres and telomerase in prostate cancer development and therapy

Graham

Meeker

2017

Nat Rev Urol

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“…Telomere length is thus directly related to aging and accordingly must be maintained in highly proliferative cells such as hematopoietic stem cells. Here, the reverse transcriptase enzyme telomerase is used to add dTTAGGG sequences to the 3′ strand of chromosomes . The very same enzyme is also used by 85–90 % of all cancers, to keep cells in their characteristic immortal state .…”

Section: Introductionmentioning

confidence: 99%

“…Here, the reverset ranscriptase enzymet elomerase is used to add dTTAGGG sequences to the 3' strand of chromosomes. [2] Thev ery same enzymei sa lso used by 85-90 %o fa ll cancers, to keep cells in their characteristicimmortal state. [3] Te lomerase inhibition is thusw idely considered as an attractive strategy in cancer therapy.…”

Section: Introductionmentioning

confidence: 99%

Hole Migration in Telomere‐Based Oligonucleotide Anions and G‐Quadruplexes

Mjekiqi

Douma

et al. 2019

Chemistry A European J

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Vacuum ultraviolet photoionization of a gas‐phase oligonucleotide anion leads to the formation of a valence hole. This hole migrates towards an energetically favorable site where it can weaken bonds and ultimately lead to bond cleavage. We have studied Vacuum UV photoionization of deprotonated oligonucleotides containing the human telomere sequence dTTAGGG and G‐quadruplex structures consisting of four dTGGGGT single strands, stabilized by NH4+ counter ions. The oligonucleotide and G‐quadruplex anions were confined in a radiofrequency ion trap, interfaced with a synchrotron beamline and the photofragmentation was studied using time‐of‐flight mass spectrometry. Oligonucleotide 12‐mers containing the 5'‐TTAGGG sequence were found to predominantly break in the GGG region, whereas no selective bond cleavage region was observed for the reversed 5'‐GGGATT sequence. For G‐quadruplex structures, fragmentation was quenched and mostly non‐dissociative single and double electron removal was observed.

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“…En este punto, hay que considerar el papel de los telómeros, que son los extremos de cada uno de los brazos del cromosoma, responsables del mantenimiento de la integridad cromosómica 3 . Con cada división celular sucesiva, los telómeros se acortan, y llega un momento en que el cromosoma no puede mantenerse íntegro, y la célula deja de dividirse, entrando en senescencia.…”

Section: Artículo De Revisiónunclassified

Envejecimiento cutáneo: causas y tratamiento

González‐Guerra¹,

Alcalá²,

Guerra‐Tapia³

2017

Más Dermatol

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El envejecimiento en general, y el cutáneo en particular, es un proceso deletéreo y universal, que, sin embargo, admite diferencias individuales en función de las causas que actúan sobre el proceso. No existe una causa única, admitiéndose diferentes teorías, entre las que se encuentran las teorías no estocásticas (no azarosas), como es la genética, en la que se incluye la de la senescencia replicativa y la de los gerontogenes; y las teorías estocásticas (azarosas), que hacen referencia al daño ambiental acumulativo a través de la oxidación y la glicación producida por tabaco, sol, contaminación y otros factores entre los que se encuentra el factor hormonal.La prevención se fundamenta en una dieta sana, ejercicio físico y evitación de los factores ambientales como el tabaco y el sol mediante la fotoprotección. En el tratamiento, se consideran la terapia hormonal sustitutiva, los cosméti-cos y cosmecéuticos, las técnicas intervencionistas que se practican en la consulta (mesoterapia, implantes o rellenos, toxina botulínica, peeling químico, láser e hilos tensores) y la cirugía estética.Palabras clave: vejez, envejecimiento cutáneo, causas, teoría estocástica, teoría no estocástica, fotoprotección, hormonas, cosméticos, rejuvenecimiento, técnicas dermoestéticas. AbsTRACTAging in general, and cutaneous in particular, is a deleterious and universal process, which nevertheless admits individual differences depending on the causes that act on the process. There is no single cause, with different theories being accepted, such as non-stochastic (non-random) theories such as genetics, including replicative senescence and gerontogenes, and stochastic (random) theories that refer to cumulative environmental damage through oxidation and glycation produced by tobacco, sun, pollution and other factors including hormone factor.Prevention is based on a healthy diet, physical exercise and avoidance of environmental factors such as tobacco

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Telomere biology: Rationale for diagnostics and therapeutics in cancer

Cited by 25 publications

References 57 publications

Telomeres and telomerase in prostate cancer development and therapy

Telomeres and telomerase in prostate cancer development and therapy

Hole Migration in Telomere‐Based Oligonucleotide Anions and G‐Quadruplexes

Envejecimiento cutáneo: causas y tratamiento

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