Telomerase Reverse Transcriptase-Promoter Mutation in Young Patients with Bladder Tumors
Sonia Pérez González,
Victoria Heredia-Soto,
Manuel Girón de Francisco
et al.
Abstract:The TERT (Telomerase Reverse Transcriptase) gene promoter mutation is one of the most prevalent mutations in urothelial bladder tumors and this mutation is related to bladder tumor progression. Our purpose was to evaluate the presence of this mutation in a population of patients who were first diagnosed at age ≤ 40 years and to examine its relationship with tumor characteristics and progression. A molecular study was performed to detect the two most prevalent mutations in the TERT promoter (C228T and C250T). T… Show more
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