Telomerase Is Involved in IL-7-Mediated Differential Survival of Naive and Memory CD4+ T Cells

Yang, Yinhua; An, Jie; Weng, Nan Ping

doi:10.4049/jimmunol.180.6.3775

Cited by 24 publications

(16 citation statements)

References 37 publications

(41 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the contrary, CD8α + CD27 - T helper cells from blood were divided into CCR7 + and CCR7 - subsets which showed little CD62L mRNA expression, indicating their improved ability to migrate into peripheral tissues. Of note, in human PBMCs, CD27 - T helper cells are enriched in the CCR7 - population [41] and differentiation of T helper cells is delineated from a CD27 + CCR7 + to a CD27 + CCR7 - and a CD27 - CCR7 - phenotype [9,42]. Similarly, in spleen and lymph nodes, we identified naïve CD8α - CCR7 + T helper cells and the majority of CD8α + cells were CCR7 - , regardless of the CD27 phenotype.…”

Section: Discussionmentioning

confidence: 99%

CD27 expression discriminates porcine T helper cells with functionally distinct properties

Reutner

Leitner

Müllebner

et al. 2013

Vet Res

View full text Add to dashboard Cite

Differentiation of porcine T helper cells is still poorly investigated, partly due to a lack of monoclonal antibodies (mAbs) specific for molecules involved in this process. Recently, we identified a mAb specific for porcine CD27 and showed that CD27 is expressed by all naïve CD8α- T helper cells but divides CD8α+ T helper cells into a CD27+ and a CD27- subset. In the present study, detailed phenotypical and functional analyses of these T-helper cell subpopulations were performed. Naïve CD8α-CD27+ T helper cells predominantly resided in various lymph nodes, whereas higher proportions of CD8α+CD27+ and CD8α+CD27- T helper cells were found in blood, spleen and liver. Both CD8α+CD27+ and CD8α+CD27- T helper cells were capable of producing IFN-γ upon in vitro polyclonal stimulation and antigen-specific restimulation. Experiments with sorted CD8α-CD27+, CD8α+CD27+ and CD8α+CD27- T-helper cell subsets following polyclonal stimulation revealed the lowest proliferative response but the highest ability for IFN-γ and TNF-α production in the CD8α+CD27- subset. Therefore, these cells resembled terminally differentiated effector memory cells as described in human. This was supported by analyses of CCR7 and CD62L expression. CD8α+CD27- T helper cells were mostly CCR7- and had considerably reduced CD62L mRNA levels. In contrast, expression of both homing-receptors was increased on CD8α+CD27+ T helper cells, which also had a proliferation rate similar to naïve CD8α-CD27+ T helper cells and showed intermediate levels of cytokine production. Therefore, similar to human, CD8α+CD27+ T helper cells displayed a phenotype and functional properties of central memory cells.

show abstract

Section: Discussionmentioning

confidence: 99%

CD27 expression discriminates porcine T helper cells with functionally distinct properties

Reutner

Leitner

Müllebner

et al. 2013

Vet Res

View full text Add to dashboard Cite

show abstract

“…The induction of telomerase was stable over time and minimized telomere loss, thus preserving the replicative lifespan of proliferating memory CD8 + T cells . Moreover, IL‐7 was also shown to activate telomerase, with higher levels in naïve rather than in memory CD4 + cells . Studies carried out in total peripheral blood lymphocytes demonstrated that the pro‐inflammatory cytokine TNF‐α promotes a rapid induction and nuclear translocation of telomerase activity through PI3‐K/Akt/(NF)‐kB activation, resulting in prevention of cell apoptosis …”

Section: Telomerase Expression and Activity In Normal Lymphocytesmentioning

confidence: 99%

Telomere/telomerase interplay in virus‐driven and virus‐independent lymphomagenesis: pathogenic and clinical implications

Dolcetti

Rossi

2010

Medicinal Research Reviews

View full text Add to dashboard Cite

Telomerase is a ribonucleoprotein complex critically involved in extending and maintaining telomeres. Unlike the majority of somatic cells, in which hTERT and telomerase activity are generally silent, normal lymphocytes show transient physiological hTERT expression and telomerase activity according to their differentiation/activation status. During lymphomagenesis, induction of persistent telomerase expression and activity may occur before or after telomere shortening, as a consequence of the different mechanisms through which transforming factors/agents may activate telomerase. Available data indicate that the timing of telomerase activation may allow the distinction of two different lymphomagenetic models: (i) an early activation of telomerase via exogenous regulators of hTERT, along with an increased lymphocyte growth and a subsequent selection of cells with increased transforming potential may characterize several virus-related lymphoid malignancies; (ii) a progressive shortening of telomeres, leading to genetic instability which favors a subsequent activation of telomerase via endogenous regulators may occur in most virus-unrelated lymphoid tumors. These models may have clinically relevant implications, particularly for the tailoring of therapeutic strategies targeting telomerase.

show abstract

“…IL-7 increased telomerase activity in naïve peripheral CD4+ cells of healthy aged adults, protecting against telomere loss and apoptosis. (66) …”

Section: Age-related Changes In Adaptive Immunitymentioning

confidence: 99%

Age-related changes in immune function: Effect on airway inflammation

Busse¹,

Mathur²

2010

Journal of Allergy and Clinical Immunology

159

141

View full text Add to dashboard Cite

Immunosenescence is defined as changes in the innate and adaptive immune response associated with increased age. The clinical consequences of immunosenescence include increased susceptibility to infection, malignancy, and autoimmunity, decreased response to vaccination and impaired wound healing. However, there are several immune alterations which may facilitate persistence of asthma into late adulthood, or development of asthma after the age of 50-60 years. Asthma in older patients is not uncommon and is a growing population as the average lifespan increases. Specific innate changes which may affect severity of asthma in older patients, or be involved in the development of late onset asthma include impaired in mucociliary clearance, and changes in airway neutrophil, eosinophil and mast cell numbers and function. Additionally, age-related altered antigen presentation and decreased in specific antibody responses may increases the risk of respiratory infections. Respiratory infections exacerbate asthma in older patients, and possibly play a role in the pathogenesis of late onset asthma. Furthermore, cytokine profiles may be modified with aging; some investigators suggesting a trend towards Th2 cytokine expression. This review examines specific innate and adaptive immune responses affected by aging that may impact the inflammatory response in older adults with asthma.

show abstract

Telomerase Is Involved in IL-7-Mediated Differential Survival of Naive and Memory CD4+ T Cells

Cited by 24 publications

References 37 publications

CD27 expression discriminates porcine T helper cells with functionally distinct properties

CD27 expression discriminates porcine T helper cells with functionally distinct properties

Telomere/telomerase interplay in virus‐driven and virus‐independent lymphomagenesis: pathogenic and clinical implications

Age-related changes in immune function: Effect on airway inflammation

Contact Info

Product

Resources

About