Telomerase expression as a predictive marker of radiotherapy response in rectal cancer: in vitro and in vivo study

Shin, Joo‐Shik; Foot, Terence; Hong, Angela; Zhang, Mei; Lum, Trina; Solomon, Michael J.; Lee, C. Soon

doi:10.1097/pat.0b013e3283511cd5

Cited by 17 publications

(10 citation statements)

References 38 publications

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“…Another important factor is the telomerase activity, present in approximately 80% of tumor malignancies , including most cases of HCC . Tumor cells have the ability to become immortal through an unlimited replicative potential due to the activation of telomerase, which is the limiting step to cell immortalization .…”

Section: Discussionmentioning

confidence: 99%

Effect of several PEO–PPO amphiphiles on bax, bcl‐2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients

Castronuovo

Cuestas

Oubiña

et al. 2015

Biotech and App Biochem

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Section: Discussionmentioning

confidence: 99%

Effect of several PEO–PPO amphiphiles on bax, bcl‐2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients

Castronuovo

Cuestas

Oubiña

et al. 2015

Biotech and App Biochem

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“…We found that AEG-1 knockdown had a radiosensitising effect in the cell lines KM12L4a, SW480, and SW620. Those cell lines are often referred to as radioresistant cells in the literature (Rödel et al , 2005; Pfeifer et al , 2009; Shin et al , 2012). However, AEG-1 knockdown in the cell lines KM12C and HCT116 showed an increased survival.…”

Section: Discussionmentioning

confidence: 99%

AEG-1 expression is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy: a study in a Swedish clinical trial

Gnosa¹,

Zhang

Brodin³

et al. 2014

Br J Cancer

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Background:Preoperative radiotherapy (RT) is widely used to downstage rectal tumours, but the rate of recurrence varies significantly. Therefore, new biomarkers are needed for better treatment and prognosis. It has been shown that astrocyte elevated gene-1 (AEG-1) is a key mediator of migration, invasion, and treatment resistance. Our aim was to analyse the AEG-1 expression in relation to RT in rectal cancer patients and to test its radiosensitising properties.Methods:The AEG-1 expression was examined by immunohistochemistry in 158 patients from the Swedish clinical trial of RT. Furthermore, we inhibited the AEG-1 expression by siRNA in five colon cancer cell lines and measured the survival after irradiation by colony-forming assay.Results:The AEG-1 expression was increased in the primary tumours compared with the normal mucosa independently of the RT (P<0.01). High AEG-1 expression in the primary tumour of the patients treated with RT correlated independently with higher risk of distant recurrence (P=0.009) and worse disease-free survival (P=0.007). Downregulation of AEG-1 revealed a decreased survival after radiation in radioresistant colon cancer cell lines.Conclusions:The AEG-1 expression was independently related to distant recurrence and disease-free survival in rectal cancer patients with RT and could therefore be a marker to discriminate patients for distant relapse.

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“…Numerous studies indicate a relation between telomerase and sensitivity of cancer cells to therapy. This observation is confirmed by the fact that an increased expression of telomerase in cancer cells correlates with their resistance to drugs [ 7 ]. Simultaneously, inhibition of telomerase activity results in an increased sensitivity of cancer cells (e.g., breast cancer) to doxorubicin (DOX) [ 8 ].…”

Section: Introductionmentioning

confidence: 82%

Telomerase and drug resistance in cancer

Lipińska

Romaniuk

Paszel-Jaworska

et al. 2017

Cell. Mol. Life Sci.

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It is well known that a decreased expression or inhibited activity of telomerase in cancer cells is accompanied by an increased sensitivity to some drugs (e.g., doxorubicin, cisplatin, or 5-fluorouracil). However, the mechanism of the resistance resulting from telomerase alteration remains elusive. There are theories claiming that it might be associated with telomere shortening, genome instability, hTERT translocation, mitochondria functioning modulation, or even alterations in ABC family gene expression. However, association of those mechanisms, i.e., drug resistance and telomerase alterations, is not fully understood yet. We review the current theories on the aspect of the role of telomerase in cancer cells resistance to therapy. We believe that revealing/unravelling this correlation might significantly contribute to an increased efficiency of cancer cells elimination, especially the most difficult ones, i.e., drug resistant.

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Telomerase expression as a predictive marker of radiotherapy response in rectal cancer: in vitro and in vivo study

Cited by 17 publications

References 38 publications

Effect of several PEO–PPO amphiphiles on bax, bcl‐2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients

Effect of several PEO–PPO amphiphiles on bax, bcl‐2, and hTERT mRNAs: An insight into apoptosis and cell immortalization induced in hepatoma cells by these polymeric excipients

AEG-1 expression is an independent prognostic factor in rectal cancer patients with preoperative radiotherapy: a study in a Swedish clinical trial

Telomerase and drug resistance in cancer

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