Telomerase: A potential molecular marker and therapeutic target for cancer

γ-H2AX in Cancer Cells: A Potential Biomarker for Cancer Diagnostics, Prediction and Recurrence

“…Recent reviews suggest using markers of cell proliferation, oncogene-induced senescence, telomerase, DNA damage repair, and corresponding epigenetic markers as general cancer biomarkers, which are powerful and promising for cancer prediction, prognosis, therapeutics, and possibly cancer prevention. [30][31][32][33][34][35] Since DNA damage is an upstream event in this concept, H2AX phosphorylation in response to DNA damage is a crucial step in the process of tumorigenesis. This makes detection of γH2AX an attractive biomarker that could serve as an early cancer indicator.…”

Dynamic Behavior of the Telomerase RNA Hairpin Structure and its Relationship to Dyskeratosis Congenita

“…5 The ability to regulate cellular activity makes telomerase a potential target for cancer development, progression, diagnosis, clinical outcome prediction, and cancerspecific targeting treatment and prevention. [6][7][8][9][10] The main components of telomerase are its reverse transcriptase and telomerase RNA containing a short template sequence (Figure 1(a)). The stability of the ribonucleoprotein complex and telomerase activity require the formation of a 0022-2836/$ -see front matter Published by Elsevier Ltd.…”

Radiotherapy Sensitization by Tumor-Specific TRAIL Gene Targeting Improves Survival of Mice Bearing Human Non–Small Cell Lung Cancer

“…Moreover, nontransfected neighboring cancer cells can be killed by a TRAIL-mediated bystander effect (10,12). We also reported that TRAIL-related hepatocyte toxicity could be prevented by using the human telomerase reverse transcriptase (hTERT) promoter, which is highly active in >85% of human cancer cells but inactive in most somatic cells (11,13).…”