2004
DOI: 10.1002/jso.20076
|View full text |Cite
|
Sign up to set email alerts
|

Telomerase: A potential molecular marker and therapeutic target for cancer

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
7
0

Year Published

2005
2005
2012
2012

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 10 publications
(7 citation statements)
references
References 14 publications
(16 reference statements)
0
7
0
Order By: Relevance
“…Recent reviews suggest using markers of cell proliferation, oncogene-induced senescence, telomerase, DNA damage repair, and corresponding epigenetic markers as general cancer biomarkers, which are powerful and promising for cancer prediction, prognosis, therapeutics, and possibly cancer prevention. [30][31][32][33][34][35] Since DNA damage is an upstream event in this concept, H2AX phosphorylation in response to DNA damage is a crucial step in the process of tumorigenesis. This makes detection of γH2AX an attractive biomarker that could serve as an early cancer indicator.…”
Section: Resultsmentioning
confidence: 99%
“…Recent reviews suggest using markers of cell proliferation, oncogene-induced senescence, telomerase, DNA damage repair, and corresponding epigenetic markers as general cancer biomarkers, which are powerful and promising for cancer prediction, prognosis, therapeutics, and possibly cancer prevention. [30][31][32][33][34][35] Since DNA damage is an upstream event in this concept, H2AX phosphorylation in response to DNA damage is a crucial step in the process of tumorigenesis. This makes detection of γH2AX an attractive biomarker that could serve as an early cancer indicator.…”
Section: Resultsmentioning
confidence: 99%
“…5 The ability to regulate cellular activity makes telomerase a potential target for cancer development, progression, diagnosis, clinical outcome prediction, and cancerspecific targeting treatment and prevention. [6][7][8][9][10] The main components of telomerase are its reverse transcriptase and telomerase RNA containing a short template sequence (Figure 1(a)). The stability of the ribonucleoprotein complex and telomerase activity require the formation of a 0022-2836/$ -see front matter Published by Elsevier Ltd.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, nontransfected neighboring cancer cells can be killed by a TRAIL-mediated bystander effect (10,12). We also reported that TRAIL-related hepatocyte toxicity could be prevented by using the human telomerase reverse transcriptase (hTERT) promoter, which is highly active in >85% of human cancer cells but inactive in most somatic cells (11,13).…”
mentioning
confidence: 99%