Telmisartan at 80 mg/Day Increases High-Molecular-Weight Adiponectin Levels and Improves Insulin Resistance in Diabetic Patients

Abstract

In diabetic patients with hypertension, high-dose telmisartan increased HMW adiponectin levels and improved insulin resistance through activation of PPAR-gamma.

Antihypertensive and metabolic effects of high-dose olmesartan and telmisartan in type 2 diabetes patients with hypertension

“…Furthermore, in metabolism olmesartan has an inflammatory effect as pleiotropic effects [15][16][17], while telmisartan has reported to increase serum adiponectine as a partial PPAR-γ agonist at the highest dose [18]. Therefore, a crossover study was performed to compare the effects of olmesartan (40 mg/day) and telmisartan (80 mg/day) on the blood pressure and metabolic profile.…”

Partial Agonist, Telmisartan, Maintains PPARγ Serine 112 Phosphorylation, and Does Not Affect Osteoblast Differentiation and Bone Mass

“…RAS is recognized as contributing to the development of osteoporosis independently of hypertension [17]–[19], and a blockage of this system either at the level of angiotensin enzyme inhibitor (ACEI) or at the level of angiotensin receptors proved to be beneficial for bone [20], [21]. Beside its anti-hypertensive activity, TEL has a unique ability to bind and activate PPARγ [22], [23] and has a beneficial effects on insulin sensitivity in humans [24]–[26] and rodents [27]. As compared to full agonists, pioglitazone and ROSI, TEL binds PPARγ in a different fashion which results in a distinct pattern of cofactors recruitment and different pharmacological effects [28].…”

Effects of telmisartan on fat distribution: a meta-analysis of randomized controlled trials

“…There were no intergroup differences in BMI in 10 studies 19-24,28-31 , and in waist circumference in 5 studies16,18,22,24,30 (WMD = -0.16 kg/m 2 , 95% CI = -0.65 to 0.32, P chi 2 = 0.004, I 2 = 62%; WMD = -1.92 cm, 95% CI = -4.68 to 0.84, P chi 2 = 0.03, I 2 = 62%, respectively). TC was evaluated in 13 studies 16-25,28-31 , TG in 13 16-24,28-31 , LDL in 916- 19,21,24,28,29,31 , and HDL-C in 12[16][17][18][19][21][22][23][24][28][29][30][31] . TC showed a significant difference between the 2 groups (SMD = -0.24, 95% CI = -0.45 to -0.03, P chi 2 = 0.0002, I 2 = 67%;figure 3).…”