Telmisartan

Sharpe, Miriam; Jarvis, Blair; Goa, Karen L.

doi:10.2165/00003495-200161100-00009

Cited by 180 publications

(40 citation statements)

References 51 publications

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“…Its importance is reflected in the immense economic value of pharmaceuticals including Valsartan [70,71] and Telmisartan [72,73], and agrochemicals such as Boscalid [74]. As alternatives to the homogeneous Pd-phosphine catalysts, Pd on carbon [75,76], on silica or polymer supports [77][78][79], and on mesoporous materials can be used [80,81].…”

Section: Suzuki-miyaura Reactionsmentioning

confidence: 99%

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

Polshettiwar

Len

Fihri

2009

Coordination Chemistry Reviews

496

225

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Section: Suzuki-miyaura Reactionsmentioning

confidence: 99%

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

Polshettiwar

Len

Fihri

2009

Coordination Chemistry Reviews

496

225

View full text Add to dashboard Cite

“…Telmisartan (TMS), an antihypertensive drug, belongs to angiotensin receptor blockers (ARBs) which act by inhibiting receptor stimulation of angiotensin II type 1 (AT1) without affecting other related receptors in cardiovascular 1 . TMS is classified as class II, low solubility high permeability, based on Biopharmaceutical Classification System (BCS).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Solid Dispersion Telmisartan – Hydroxypropyl Methyl Cellulose(HPMC) E5 LV by Co-Grinding Method

Zaini¹,

Fitriani²,

Effendy³

et al. 2017

Orient. J. Chem

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Telmisartan (TMS), an antihypertensive drug, is classified as class II according to Biopharmaceutical Classification System (BCS) with low solubility and high permeability. The purpose of this study was to prepare and characterize solid dispersion of TMS with hidroxypropyl methyl cellulose (HPMC) E5 LV to increase the solubility. Solid dispersion was prepared in three different ratio TMS:HPMC 2:1, 1:1, and 1:2 (w/w) by co-grinding method for 60 minutes. Solubility test was conducted in distilled water for 72 hours and the amount of TMS was determined by spectrophotometry UV. Result of Powder X-Ray Diffraction (PXRD) showed a decrease in intensity of TMS in accordance with the amount of HPMC E5 LV in solid dispersion. Fourier Transform Infra-Red(FT-IR)Spectra showed no significant shift of wavelength. Scanning Electron Microscopy (SEM) result presented the crystalline form of TMS, while both physical mixture and solid dispersion at different ratio showed TMS stick on the surface of HPMC E5 LV. Thermogram of Differential Scanning Calorimetry (DSC) showed an incline of endotherm peak as the ratio HPMC E5 LV increased. The solubility result of intact TMS was 0.49±0.03µg/mL, while the physical mixture and solid dispersion 2:1, 1;1 and 1:2 were 1.87±0.18 µg/mL, 5.36±0.48 µg/mL, 7.24±1.73µg/mL, and 14.89±1.49 µg/mL, respectively. In conclusion, solid dispersion of telmisartan-HPMC E5 LV enhanced the solubility of TMS.

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“…The methods [3][4][5][6][7][8][9][10][11] for telmisartan in combination with other drugs in plasma, serum and in tablets by high-performance liquid chromatography (HPLC) and [12][13][14][15][16][17] for the estimation of hydrochlorothiazide in combination with other drugs in serum and is in tablets by high-performance liquid chromatography (HPLC). A stability indicating LC method has been reported for telmisartan as well as hydrochlorothiazide.…”

Section: Telmisartan a Nonpeptide Molecule Is Chemically 4'-[(14-dmentioning

confidence: 99%

Stability - Indicating Lc Method for the Simultaneous Determination of Telmisartan and Hydrochlorothiazide in Dosage Form

Patil

Shinde

2012

J. Chil. Chem. Soc.

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A simple, rapid, and precise method is developed for the quantitative simultaneous estimation of telmisartan and hydrochlorothiazide in combined pharmaceutical dosage form. A chromatographic separation of the two drugs was achieved with an ACE 5 C 18 (250 x 4.6 mm) analytical column using buffer-acetonitrile (55:45 v/v). The buffer used in mobile phase contains 0.1M sodium perchlorate monohydrate in double distilled water pH adjusted 3.0 with trifluoroacetic acid. The instrumental settings are flow rate of 1.5 ml min -1 , column temperature at 30 o C, and detector wavelength of 215 nm using a photodiode array detector. The resolution between hydrochlorothiazide and telmisartan founds to be more than 5. Theoretical plates for hydrochlorothiazide and telmisartan were 13022 and 6629 respectively. Tailing factor for hydrochlorothiazide and telmisartan was 0.94 and 0.98 respectively. Telmisartan, hydrochlorothiazide and their combination drug products stressed samples were analysed by the proposed method. The described method shows excellent linearity over a range of 70 to 130% of target analyte concentration. The correlation coefficient for telmisartan and hydrochlorothiazide are 0.9999. The relative standard deviation for six measurements in two sets of each drug in tablets is always less than 2%. The proposed method was found to be suitable and accurate for quantitative determination and stability study of telmisartan and hydrochlorothiazide in pharmaceutical preparations.

show abstract

Telmisartan

Cited by 180 publications

References 51 publications

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

Silica-supported palladium: Sustainable catalysts for cross-coupling reactions

Preparation and Characterization of Solid Dispersion Telmisartan – Hydroxypropyl Methyl Cellulose(HPMC) E5 LV by Co-Grinding Method

Stability - Indicating Lc Method for the Simultaneous Determination of Telmisartan and Hydrochlorothiazide in Dosage Form

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