Tellurium as a valuable tool for studying the prokaryotic origins of mitochondria

Pontieri, Paola; Stefano, Mario De; Massardo, Domenica Rita; Gunge, Norio; Miyakawa, Isamu; Sando, Nobundo; Pignone, Domenico; Pizzolante, Graziano; Romanò, Roberta; Alifano, Pietro; Giudice, Luigi Del

doi:10.1016/j.gene.2015.01.060

Cited by 3 publications

(1 citation statement)

References 73 publications

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“…Accumulated experimental data indicate that tellurium not only exhibits a well-documented garlic-like odor but also exerts significant neurotoxic effects. In the past, Te has been employed as a valuable tool for studying the evolutionary origins of mitochondria in prokaryotes [134]. Recently, a research paper was published focusing on neurodegenerative diseases, utilizing Te as an investigative tool and the yeast S. cerevisiae as a model system [40].…”

Section: The Connection Between Mitochondrial Dysfunctions and The Ef...mentioning

confidence: 99%

Mitochondrial Neurodegenerative Diseases: Three Mitochondrial Ribosomal Proteins as Intermediate Stage in the Pathway That Associates Damaged Genes with Alzheimer’s and Parkinson’s

Giudice

Pontieri

Aletta

et al. 2023

Biology

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Currently, numerous research endeavors are dedicated to unraveling the intricate nature of neurodegenerative diseases. These conditions are characterized by the gradual and progressive impairment of specific neuronal systems that exhibit anatomical or physiological connections. In particular, in the last twenty years, remarkable efforts have been made to elucidate neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease. However, despite extensive research endeavors, no cure or effective treatment has been discovered thus far. With the emergence of studies shedding light on the contribution of mitochondria to the onset and advancement of mitochondrial neurodegenerative disorders, researchers are now directing their investigations toward the development of therapies. These therapies include molecules designed to protect mitochondria and neurons from the detrimental effects of aging, as well as mutant proteins. Our objective is to discuss and evaluate the recent discovery of three mitochondrial ribosomal proteins linked to Alzheimer's and Parkinson's diseases. These proteins represent an intermediate stage in the pathway connecting damaged genes to the two mitochondrial neurological pathologies. This discovery potentially could open new avenues for the production of medicinal substances with curative potential for the treatment of these diseases.

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Section: The Connection Between Mitochondrial Dysfunctions and The Ef...mentioning

confidence: 99%

Mitochondrial Neurodegenerative Diseases: Three Mitochondrial Ribosomal Proteins as Intermediate Stage in the Pathway That Associates Damaged Genes with Alzheimer’s and Parkinson’s

Giudice

Pontieri

Aletta

et al. 2023

Biology

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Mitochondrial ribosomal protein genes connected with Alzheimer’s and tellurite toxicity

Giudice¹,

Alifano

Calcagnile

et al. 2022

Mitochondrion

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Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch

Palma

Danes

et al. 2020

Antioxidants & Redox Signaling

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Tellurium as a valuable tool for studying the prokaryotic origins of mitochondria

Cited by 3 publications

References 73 publications

Mitochondrial Neurodegenerative Diseases: Three Mitochondrial Ribosomal Proteins as Intermediate Stage in the Pathway That Associates Damaged Genes with Alzheimer’s and Parkinson’s

Mitochondrial Neurodegenerative Diseases: Three Mitochondrial Ribosomal Proteins as Intermediate Stage in the Pathway That Associates Damaged Genes with Alzheimer’s and Parkinson’s

Mitochondrial ribosomal protein genes connected with Alzheimer’s and tellurite toxicity

Mitochondrial Superoxide Dismutase: What the Established, the Intriguing, and the Novel Reveal About a Key Cellular Redox Switch

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