“…10,11 Meta-analyses have shown that, among individuals who are refractory to treatment with methadone, supervised injectable diacetylmorphine is beneficial in terms of reducing illicit opioid use, premature treatment discontinuation (or "treatment dropout"), criminal activity, incarceration and mortality, as well as improving overall health and social functioning, quality of life and stability. [12][13][14][15][16][17] In response to regulatory barriers limiting the provision of diacetylmorphine for the treatment of opioid use disorder in Canada, the Study to Assess Longer-term Opioid Medication Effectiveness (SALOME) trial compared injectable hydromorphone to injectable diacetylmorphine and found that both medications, delivered in identical conditions, showed positive outcomes such as high retention rates and reduction of street opioid use (from daily to a few days per month) and illegal activities. 14 Thus, in jurisdictions where diacetylmorphine is currently not available, or for patients in whom it is contraindicated or unsuccessful, hydromorphone may provide an effective, licensed alternative.…”