Telepaque Opacification of Radiolucent Biliary Calculi

Salzman, Emanuel; Warden, M R

doi:10.1148/71.1.85

Cited by 13 publications

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“…Gallstones have a particular affinity for the compound and develop a “rim sign” (Figure 1), where the stones themselves light up on radiography after only a few hours of absorption. 3 This absorption would persist after the contrast had washed out and abdominal x-rays would show gallstones without visualization of the gallbladder. In patients whose gall disease was caused by the presence of sludge, sabulography could be performed, where patients would be given high doses of telepaque.…”

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confidence: 99%

Diagnostics in a Surgeon’s Pocket—The History of Telepaque and Oral Cholecystograms

Lodin

Lopez

Lopez-Viego

et al. 2023

The American Surgeon™

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Biliary diseases such as cholelithiasis, choledocholithiasis, and cholecystitis all rely on imaging modalities to help make diagnoses. In modern times, ultrasound, computer tomography, and nuclear medicine scans help precisely visualize biliary and hepatic anatomy and pathology. The predecessor of these imaging modalities was the cholecystogram. This involved administration of contrast media that reliably had hepatic uptake and biliary excretion without causing significant side effects followed by radiograms of the abdomen. In the 1950s, iopanoic acid, known as telepaque, was a novel oral contrast, developed and clinical trialed for the use in diagnosing biliary pathology. A small, off-white colored powder available in a pill form, telepaque was readily available, conveniently administered by physicians at the bedside and produced beautiful cholangiograms within hours of administration. This paper briefly discusses the advent, physiology, and use of this novel compound that helped surgeons for many decades.

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confidence: 99%

Diagnostics in a Surgeon’s Pocket—The History of Telepaque and Oral Cholecystograms

Lodin

Lopez

Lopez-Viego

et al. 2023

The American Surgeon™

View full text Add to dashboard Cite

show abstract

“…Since the development of excretory cholecystography by Graham and Cole in 1924, progresses and improvements have been made by: (1) newer contrast media resulting in greater degree of opacification and decreased incidence of adverse reactions, (2) improved opacification by increased doses of contrast medium, for example the double dose method (Salzman and Warden 1958) and drip infusion cholecystography (Dijan and Annonier 1964).…”

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confidence: 99%