Telemetric capsule-based upper gastrointestinal tract – blood detection – first multicentric experience

Brunk, Thomas; Schmidt, Arthur; Hochberger, J; Wedi, Edris; Meier, Benjamin; Braun, Georg; Neser, Frank; Schneider, M; Kandler, Jennis; Bauerfeind, Peter; Repp, Michael; Weingart, V.; Brand, Markus; Caca, Karel; Wannhoff, Andreas; Messmann, Helmut; Karpynec, Symon; Kubisch, Ilja; Albért, J; Neuhaus, H; Schmitz, Lukas; Allescher, Hans–Dieter; Meining, Alexander; Kuellmer, Armin

doi:10.1080/13645706.2021.1954534

Cited by 11 publications

(5 citation statements)

References 23 publications

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“…43 In particular, video capsule endoscopies (VCEs) have proven to be highly efficacious in their capability to detect and localize bleeding, as shown in several prospective clinical trials. [44][45][46][47][48] Interestingly, Brunk et al 44 showed that by using VCEs, nearly 80% of hospital admissions made based on the GBS score alone could have been avoided. In another study, Chandran et al 45 demonstrated that five times more patients could be safely managed in an outpatient environment than currently managed using current GBS score cutoffs.…”

Section: Discussionmentioning

confidence: 99%

Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding

2024

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Background/Aims: Upper gastrointestinal bleeding (UGIB) is a life-threatening condition that necessitates early identification and intervention and is associated with substantial morbidity, mortality, and socioeconomic burden. However, several diagnostic challenges remain regarding risk stratification and the optimal timing of endoscopy. The PillSense System is a noninvasive device developed to detect blood in patients with UGIB in real time. This study aimed to assess the safety and performance characteristics of PillSense using a simulated bleeding model.Methods: A preclinical study was performed using an in vivo porcine model (14 animals). Fourteen PillSense capsules were endoscopically placed in the stomach and blood was injected into the stomach to simulate bleeding. The safety and sensitivity of blood detection and pill excretion were also investigated.Results: All the sensors successfully detected the presence or absence of blood. The minimum threshold was 9% blood concentration, with additional detection of increasing concentrations of up to 22.5% blood. All the sensors passed naturally through the gastrointestinal tract.Conclusions: This study demonstrated the ability of the PillSense System sensor to detect UGIB across a wide range of blood concentrations. This ingestible device detects UGIB in real time and has the potential to be an effective tool to supplement the current standard of care. These favorable results will be further investigated in future clinical studies.

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Section: Discussionmentioning

confidence: 99%

Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding

2024

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“…However, white-light capsule endoscopes are only one of several capsule applications available for GI investigation [ 10 ]. Among the non-white light capsule endoscopes (NWLCEs) already available for market or on trial for market approval is HemoPill (Ovesco Endoscopy AG), designed specifically for the detection of bleeding in the esophagus, stomach, and SB [ 11 ]. Others include Medtronic’s SmartPill [ 12 , 13 ], (now withdrawn from the market), and eCelsius (BodyCAP) for continuous core body temperature monitoring [ 14 ].…”

Section: Current Practice Of Using Gastrointestinal Capsulesmentioning

confidence: 99%

Conference Report: The FutuRE oF MinimalLy InvasivE GI and Capsule DiagnosTics (REFLECT) Nyborg, Denmark, October 2023

Selnes,

Thorndal,

Hansen

et al. 2024

Diagnostics

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“…Die HemoPill ist eine kleine schluckbare Sensorkapsel, die bereits kleinste Mengen Blut im oberen GI-Trakt detektiert und den Nachweis in Echtzeit an einen tragbaren Empfänger übermittelt. Das Verfahren ist aktuell noch experimenteller Natur; erste klinische Daten wurden kürzlich publiziert [5]. Ein restriktives Transfusionsmanagement mit Transfusionen ab einem Hämoglobin von unter 7 g/dl hat sich hinsichtlich der Gesamtletalität gegenüber einem liberalen Management mit Transfusionen ab Werten von unter 9 g/dl als überlegen gezeigt [6].…”

Section: Merkeunclassified

Gastrointestinale Blutungen

Meier¹,

Caca²

2023

Dtsch Med Wochenschr

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Gastrointestinale Blutungen sind häufig und können anhand der Anamnese und mithilfe klinischer und laborchemischer Untersuchungen schnell diagnostiziert werden. Die weitere Behandlung sollte dann endoskopisch unter stationären Bedingungen erfolgen. Dieser CME-Artikel gibt eine detaillierte Übersicht zum klinischen Management und stellt verschiedene endoskopische Vorgehensweisen in Abhängigkeit von der Blutungslokalisation vor.

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Telemetric capsule-based upper gastrointestinal tract – blood detection – first multicentric experience

Cited by 11 publications

References 23 publications

Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding

Preclinical study of a novel ingestible bleeding sensor for upper gastrointestinal bleeding

Conference Report: The FutuRE oF MinimalLy InvasivE GI and Capsule DiagnosTics (REFLECT) Nyborg, Denmark, October 2023

Gastrointestinale Blutungen

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