Telangiectatic Osteosarcoma: Radiologic-Pathologic Comparison

Murphey, Mark D.; Jaovisidha, Suphaneewan; Temple, H. Thomas; Gannon, Francis H.; Jelinek, James S.; Malawer, Martin M.

doi:10.1148/radiol.2292021130

Cited by 130 publications

(93 citation statements)

References 24 publications

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“…In these bones the metaphysis is the usual site of origin [9,10,15]. Other bones such as the sternum, scapula [6] ribs, innominate bone [6], cranial vault [15] and mandible may likewise be involved. TOS of spine is exceedingly rare [5].…”

Section: Discussionmentioning

confidence: 99%

“…Magnetic resonance imaging may show areas of high signal intensity on T 2 -weighted as well as T 1 weighted images (a feature that is unusual with other neoplasm) [6]and the presence of fluid-fluid levels. Fluid-fluid levels are suggestive of haemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…TOS is characterized by multiple aneurysmal dilated blood filled cavities with high grade, sarcomatous cells in the peripheral rim and septa [6]. The distinction must ultimately rest on the finding of these obviously anaplastic cells [10], atypical mitotic figure and irregular closely packed lace like osteoid [1].…”

Section: Discussionmentioning

confidence: 99%

“…The D 6-7 disc space was reduced on the right. A large pre and paravertebral component was seen in relation to D 6 . The MRI (Fig.…”

Section: Case Historymentioning

confidence: 94%

“…The MRI (Fig. 2a, b) showed altered signal intensity seen within the D 5,6 and D 7 vertebral bodies. There was complete destruction of the D 6 body (Fig.…”

Section: Case Historymentioning

confidence: 98%

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Telangiectatic osteosarcoma of the spine: a case report

et al. 2008

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Telangiectatic osteosarcoma (TOS) of the spine is rare accounting for only 0.08% of all primary osteosarcomas. Though a well described radio-pathological entity it is not often thought of as a cause of paraplegia. We describe the clinical, radiological and pathological features and discuss the treatment options of telangiectatic osteosarcoma of the dorsal spine presenting in a young man. The diagnostic pitfalls are discussed emphasising the fact that the diagnosis of TOS of the spine requires not only a multi modal approach of appropriate radiological and pathological tests but also an awareness of this condition.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…The D 6-7 disc space was reduced on the right. A large pre and paravertebral component was seen in relation to D 6 . The MRI (Fig.…”

Section: Case Historymentioning

confidence: 94%

“…The MRI (Fig. 2a, b) showed altered signal intensity seen within the D 5,6 and D 7 vertebral bodies. There was complete destruction of the D 6 body (Fig.…”

Section: Case Historymentioning

confidence: 98%

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Telangiectatic osteosarcoma of the spine: a case report

et al. 2008

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Telangiectatic osteosarcoma: The St. Jude Children's Research Hospital's experience

Weiss

Khoury

Hoffer

et al. 2007

Cancer

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BACKGROUND. Telangiectatic osteosarcoma (TOS) isRESULTS. Among 323 patients with OS, 22 patients (6.8%) had TOS. Two additional patients who were treated in Chile on a recent OS trial were included. The median age at diagnosis of the 24 patients was 15.7 years. Four patients (17%) had metastatic disease, and 9 of 21 patients (43%) had pathologic fractures. Only 5 patients (who were treated after 1994) underwent limb-salvage surgery.Estimates of 5-year event-free survival (58.3% AE 11.9%) and overall survival (66.8% AE 11.6%) were similar to those for patients with other OS subtypes (P ! .85). The absence of local disease progression and chemotherapy with !3 agents that were active against OS were correlated with improved outcome (P .005).The presence of a pathologic fracture was not associated with surgery type or patient outcome.CONCLUSIONS. TOS was associated with a high rate of pathologic fracture. With multimodality therapy, the outcome of patients with TOS was similar to that of patients with other high-grade OS subtypes. The absence of local disease progression and chemotherapy with !3 active agents were associated with a favorable outcome.

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Massive aneurysmal bone cyst of the skull base treated with denosumab

et al. 2018

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Background Aneurysmal bone cysts are rare, benign expansile tumors most commonly involving long bones and vertebrae in patients younger than age 20. Skull base involvement is rare. Aneurysmal bone cysts shares radiological and histological features with other bone tumors, posing a diagnostic challenge. Methods/Results We report the case of a 32‐year‐old man who presented with facial pain, epistaxis, and cranial neuropathies secondary to a massive tumor of the maxillary sinus and anterior skull base. The tumor was originally misdiagnosed as osteosarcoma. However, genomic analysis revealed a rearrangement in the USP6 gene, elucidating a diagnosis of primary aneurysmal bone cysts. The patient was treated with denosumab. Within 5 months, the patient was asymptomatic with CT showing ossification of the tumor. Conclusions This case highlights (1) the utility of genomic analysis in aggressive bone tumors when the diagnosis is unclear and (2) the effectiveness of denosumab as a treatment for aneurysmal bone cysts when surgical resection is unfavorable.

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Telangiectatic Osteosarcoma: Radiologic-Pathologic Comparison

Abstract: CT and MR imaging findings of telangiectatic osteosarcoma often include thick nodular tissue (and matrix mineralization at CT) in a largely hemorrhagic and/or necrotic osseous lesion with an associated soft-tissue mass, which allows distinction from aneurysmal bone cyst.

Cited by 130 publications

References 24 publications

Telangiectatic osteosarcoma of the spine: a case report

Telangiectatic osteosarcoma of the spine: a case report

Telangiectatic osteosarcoma: The St. Jude Children's Research Hospital's experience

Massive aneurysmal bone cyst of the skull base treated with denosumab

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