Telangiectatic cutaneous metastasis from lung adenocarcinoma

Park, Jae-Jeong; Choi, You Duk; Lee, Jee-Bum; Kim, Seong‐Jin; Lee, Seung−Chul; Won, Young Ho; Yun, Sook Jung

doi:10.1016/j.jaad.2009.08.022

Cited by 6 publications

(6 citation statements)

References 5 publications

(4 reference statements)

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“…5 Clinically, cutaneous lesions have been described as solitary or multiple nodules with variable red to pink and violaceous color, firm consistence, adhered to deeper tissues, and sometimes ulcerated. 86 Some patients develop metastases at the tip of the nose, the so-called clown nose sign 87 (Fig. Sometimes, these cutaneous nodules resemble those of vascular lesions.…”

Section: Cutaneous Metastases From Lung Cancermentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

219

104

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Skin metastases occur in 0.6%-10.4% of all patients with cancer and represent 2% of all skin tumors. Skin metastases from visceral malignancies are important for dermatologists and dermatopathologists because of their variable clinical appearance and presentation, frequent delay and failure in their diagnosis, relative proportion of different internal malignancies metastasizing to the skin, and impact on morbidity, prognosis, and treatment. Another factor to take into account is that cutaneous metastasis may be the first sign of clinically silent visceral cancer. The relative frequencies of metastatic skin disease tend to correlate with the frequency of the different types of primary cancer in each sex. Thus, women with skin metastases have the following distribution in decreasing order of frequency of primary malignancies: breast, ovary, oral cavity, lung, and large intestine. In men, the distribution is as follows: lung, large intestine, oral cavity, kidney, breast, esophagus, pancreas, stomach, and liver. A wide morphologic spectrum of clinical appearances has been described in cutaneous metastases. This variable clinical morphology included nodules, papules, plaques, tumors, and ulcers. From a histopathologic point of view, there are 4 main morphologic patterns of cutaneous metastases involving the dermis, namely, nodular, infiltrative, diffuse, and intravascular. Generally, cutaneous metastases herald a poor prognosis. The average survival time of patients with skin metastases is a few months. In this article, we review the clinicopathologic and immunohistochemical characteristics of cutaneous metastases from internal malignancies, classify the most common cutaneous metastases, and identify studies that may assist in diagnosing the origin of a cutaneous metastasis.

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Section: Cutaneous Metastases From Lung Cancermentioning

confidence: 99%

Cutaneous Metastases From Internal Malignancies

Alcaraz

Cerroni

Rütten

et al. 2012

The American Journal of Dermatopathology

219

104

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“…Our patient had been diagnosed with livedo‐reticularis‐like inflammatory cutaneous metastasis of SRC gastric cancer. So far, livedo‐like cutaneous metastases have been reported only in lung, breast, and urothelial visceral cancers 14‐16 . Inflammatory cutaneous metastasis has been attributed to direct spread of tumor cells through dermal lymphatic vessels 1,3,7 .…”

Section: Discussionmentioning

confidence: 99%

“…Livedo‐reticularis‐like cutaneous metastasis from internal malignancies has been linked to infiltration of dermal lymphatics by the underlying malignancy, rather than intravascular obstruction with thrombosis or emboli as in actual livedo reticularis 14 . Likewise, telangiectatic cutaneous metastasis ( carcinoma telangiectoides ) from internal malignancies has also been ascribed to lymphatic obstruction by tumor emboli 7,15 . The presence of tumor emboli in dermal lymphatics, termed dermal lymphatic carcinomatosis , is known to portend a poorer prognosis 14,15 .…”

Section: Discussionmentioning

confidence: 99%

“…So far, livedo-like cutaneous metastases have been reported only in lung, breast, and urothelial visceral cancers. [14][15][16] Inflammatory cutaneous metastasis has been attributed to direct spread of tumor cells through dermal lymphatic vessels. 1,3,7 Spiers and Fakarzadeh 14 have reported a case of livedoid inflammatory cutaneous metastasis in a patient with breast cancer; histopathology in their case revealed metastatic breast carcinoma with prominent lymphatic involvement.…”

Section: Discussionmentioning

confidence: 99%

“…14 Likewise, telangiectatic cutaneous metastasis (carcinoma telangiectoides) from internal malignancies has also been ascribed to lymphatic obstruction by tumor emboli. 7,15 The presence of tumor emboli in dermal lymphatics, termed dermal lymphatic carcinomatosis, is known to portend a poorer prognosis. 14,15 Thus, inflammatory forms of gastric cutaneous metastases might hint at a lower overall survival, as compared with the nodular forms.…”

Section: Discussionmentioning

confidence: 99%

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Livedoid cutaneous metastasis of signet‐ring cell gastric carcinoma

et al. 2021

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Cutaneous metastasis of gastric cancer is extremely rare. Nodular forms are more common and inflammatory forms are exceptionally encountered. Herein, we report a case of inflammatory cutaneous metastasis of signet‐ring cell gastric cancer (poorly cohesive gastric carcinoma with signet‐ring cell component) masquerading as livedo reticularis. To our knowledge, such a clinical presentation of cutaneous metastasis has not been reported for gastric cancer. It is imperative to preserve a high index of clinical suspicion for diagnosing cutaneous metastases. Our case highlights the importance of obtaining a skin biopsy in patients with a known history of internal malignancy. Bizarre, newly erupting, evolving, persistent, or treatment‐refractory dermatologic lesions (such as nodules, ulcers, erythematous, reticular, or livedoid patches) might be clues for an underlying internal malignancy and require prompt histopathological sampling. Personal medical history, histopathological examination, and immunohistochemical profiling are equally important in distinguishing primary cutaneous carcinomas from secondary metastatic deposits. Early recognition of a cutaneous metastasis might enable appropriate staging and timely intervention, thereby prolonging survival.

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