Tejido adiposo epicárdico: un marcador de riesgo cardiovascular a evaluar en la enfermedad renal crónica

D’Marco, Luis; Cortez, Marie; Salazar, Maria G.; Lima-Martínez, Marcos M.; Bermúdez, Valmore

doi:10.1016/j.arteri.2019.10.006

Cited by 1 publication

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“…Recognition of the adipocyte as a cell type with complex functioning including endocrine, paracrine and autocrine capacity has aroused research interest in disciplines such as nephrology, cardiology, and endocrinology, and it has become a fertile ground for scientific debate. Its wide heterogeneity of location, functions, proteomics, and metabolomics ( 1 ) are particularly important in adiposity, where changes in function and volume are associated with increased cardiorenal and metabolic risk ( Figure 1 ).…”

Section: Organ-specific Fat As Causative Factor Of Cardiorenal Diseasementioning

confidence: 99%

“…Interest in the potential impact of organ-specific adipose tissue on cardiac and renal pathophysiology is growing, and it is clinically important to determine the mechanisms by which fat compartments around the heart and kidneys influence cardiovascular disease (CVD) in both general and high-risk populations ( 1 , 2 ). In these sense, epicardial fat (EF) and perirenal fat (PF) have been associated with adverse outcomes in chronic kidney disease (CKD) patients ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

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Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

et al. 2021

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There is a growing interest in the potential role of adipose tissues in cardiac and renal pathophysiology, and determining the mechanisms by which fat compartments around the heart and kidneys influence cardiovascular disease is of clinical importance in both general and high-risk populations. Epicardial fat and perirenal fat have been associated with adverse outcomes in chronic kidney disease (CKD) patients. Epicardial fat is a rich source of free fatty acids and is capable of secreting inflammatory and pro-atherogenic cytokines that promote atherosclerosis through a local paracrine effect. Recent evidence has demonstrated that perirenal fat has a closer correlation with kidney diseases than other visceral fat deposits in obesity or metabolic disturbances. Moreover, perirenal fat has been reported as an independent risk factor for CKD progression and even associated with cardiorenal dysfunction. Accordingly, these forms of organ-specific fat deposits may act as a connecter between vascular and cardiorenal disease. This review explores the possible links between epicardial and perirenal fat and its significant role as a modulator of cardiorenal dysfunction in CKD patients.

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Section: Organ-specific Fat As Causative Factor Of Cardiorenal Diseasementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

et al. 2021

View full text Add to dashboard Cite

show abstract

Tejido adiposo epicárdico: un marcador de riesgo cardiovascular a evaluar en la enfermedad renal crónica

Cited by 1 publication

References 50 publications

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

Cardiorenal Fat: A Cardiovascular Risk Factor With Implications in Chronic Kidney Disease

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