Teixobactin: a novel anti-infective agent

McCarthy, Matthew W

doi:10.1080/14787210.2019.1550357

Cited by 17 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…No toxicity to mammalian cells was reported and no mutants of S. aureus or Mycobacterium tuberculosis resistant to teixobactin were obtained in laboratory resistance induction experiments, suggesting that developing resistance is expected to be difficult. In vivo studies in murine models indicated that teixobactin has the potential to be a good treatment for human MRSA infections [68]. (14), cannabichromene (15), cannabigerol (16), cannabidiol (17), cannabinol (18), ∆9-tetrahydrocannabinol (19), DCAP (20), and Odilorhabdins (21).…”

Section: Teixobactinmentioning

confidence: 99%

Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches

2020

View full text Add to dashboard Cite

The discovery of antibiotics has created a turning point in medical interventions to pathogenic infections, but unfortunately, each discovery was consistently followed by the emergence of resistance. The rise of multidrug-resistant bacteria has generated a great challenge to treat infections caused by bacteria with the available antibiotics. Today, research is active in finding new treatments for multidrug-resistant pathogens. In a step to guide the efforts, the WHO has published a list of the most dangerous bacteria that are resistant to current treatments and requires the development of new antibiotics for combating the resistance. Among the list are various Gram-positive bacteria that are responsible for serious healthcare and community-associated infections. Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and drug-resistant Streptococcus pneumoniae are of particular concern. The resistance of bacteria is an evolving phenomenon that arises from genetic mutations and/or acquired genomes. Thus, antimicrobial resistance demands continuous efforts to create strategies to combat this problem and optimize the use of antibiotics. This article aims to provide a review of the most critical resistant Gram-positive bacterial pathogens, their mechanisms of resistance, and the new treatments and approaches reported to circumvent this problem.

show abstract

Section: Teixobactinmentioning

confidence: 99%

Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches

2020

View full text Add to dashboard Cite

show abstract

“…65 Teixobactin (Figure 4) is a depsipeptide synthesized from 11 amino acids. 66 It is active against S. aureus, including MRSA (MICs = 0.078-0.31 µg/ml), enterococci (MICs = 0.31-0.63 µg/ml), and other Gram-positive bacteria. 67 Teixobactin binds to the lipid II, inhibits the synthesis of peptidoglycan and teichoic acid, alters the localization of AltA (autolysin), and overall triggers cell lysis.…”

Section: Outlooksmentioning

confidence: 99%

Role of membrane proteins in bacterial resistance to antimicrobial peptides

Vimberg

Buriánková

Mazumdar

et al. 2021

Medicinal Research Reviews

View full text Add to dashboard Cite

Several natural antimicrobial peptides (AMPs), including the novel semisynthetic lipoglycopeptide antibiotics telavancin, dalbavancin, and oritavancin, have been approved for clinical use to address the growing problem of multiple antibioticresistant Gram-positive bacterial infections. Nevertheless, the efficacy of these antibiotics has already been compromised. The SARS-CoV-2 pandemic led to the increased clinical use of all antibiotics, further promoting the development of bacterial resistance. Therefore, it is critical to gain a deeper understanding of the role of resistance mechanisms to minimize the consequential risks of long-term antibiotic use and misuse.Here, we summarize for the first time the current knowledge of resistance mechanisms that have been shown to cause resistance to clinically used AMPs, with particular focus on membrane proteins that have been reported to interfere with the activity of AMPs by affecting the binding of AMPs to bacteria.

show abstract

“…However, there is a further point to consider, i.e., is there a general wish to fight the drug-resistance threat scientifically, or rather, merely to discover/develop new antimicrobial drugs of the same type, to be employed in the same way? Most scientific reviews and media coverage seem to imply the latter, with the majority of articles/programmes covering the search for replacement antibiotics, such as teixobactin [3], and only a tiny fraction being dedicated to other methods, usually biological, such as vaccination or the use of bacteriophages [4]. The search for these new replacement agents has the same rationale as that of 70 years earlier, i.e., compounds produced by microorganisms for chemical defence against other microorganisms, only in different areas of the globe, or using alternative culturing methods (e.g., teixobactin).…”

Section: Fighting Resistancementioning

confidence: 99%

A New Penicillin?

Wainwright

2020

Antibiotics

View full text Add to dashboard Cite

The spectre of antimicrobial resistance looms very large indeed in the 21st century; the supply of efficacious conventional drugs is short and not guaranteed, for various reasons. It is time to look elsewhere for answers and for protocols which might be used in tandem with our diminishing arsenal in order to protect vital drugs. This could bridge the gap before new development in conventional antimicrobial therapy occurs, or might be a longer-term solution, particularly in the area of infectious disease prophylaxis (conventional-sensitive or -resistant). Reliable and safe protocols have been developed for the use of photoantimicrobials in this respect, offering much greater coverage, in terms of the microbial target, than Fleming ever imagined.

show abstract

Teixobactin: a novel anti-infective agent

Cited by 17 publications

References 26 publications

Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches

Resistance of Gram-Positive Bacteria to Current Antibacterial Agents and Overcoming Approaches

Role of membrane proteins in bacterial resistance to antimicrobial peptides

A New Penicillin?

Contact Info

Product

Resources

About