Teicoplanin Pharmacokinetics During Albumin Dialysis

Weiler, Stefan; Falkensammer, Gerda; Seger, Christoph; Joannidis, Michael; Bellmann, Romuald

doi:10.1111/j.1525-1594.2010.01198.x

Cited by 3 publications

(2 citation statements)

References 19 publications

(21 reference statements)

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“…In addition to these factors, the residual endogenous renal clearance is an important covariate which predicts the systemic clearance of the antibiotic and is responsible for heterogeneity in the clearance, making it di cult to have simple dosing recommendations as "one size does not t all" CRRT patients [45,46]. For example, teicoplanin clearance not only depends on variables effecting CRRT but also on the hypoalbuminemia state (highly PPB) leading to high availability of unbound form for clearance [47].…”

Section: A Renal Replacement Therapy (Rrt)mentioning

confidence: 99%

Clinical Pharmacokinetics and dose optimization of anti-infectives in critical care: A narrative review

Bhandari

Rohilla

Shafiq

et al. 2023

Preprint

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Critically ill patients with infections present with considerable challenges in antimicrobial use due to multiple reasons such as pathophysiological alterations, comorbidities, supportive treatment and the pathogenicity of implicated organism. Fluid shifts, hyperdynamic state, altered renal clearance are the rapid changes which are often not considered while administering antimicrobials. Vital organ dysfunction with or without Multi–Organ Dysfunction Syndrome (MODS) often necessitates use of supportive management in the form of Ventilatory Support or Renal Replacement Therapy (RRT) to Extracorpeal Membrane Oxygenation (ECMO) to name a few. These supportive measures may have implication on PK-PD of administered antimicrobials. Certain patient parameters such as age, weight, comorbid illnesses like cystic fibrosis, burns or immunocompromised state can be important determinants of pharmacokinetics and pharmacodynamics (PK-PD) of antimicrobials. Issues such as bioavailability of the antimicrobial at the primary focus of infection need to be taken into consideration while making choice of antimicrobial(s) and deciding a dose. The critical pharmacodynamic parameters that need to be taken into account consider are disease state, altered bacterial susceptibility, pathogenicity and localization of the organism and host immunity while making decisions about optimized antimicrobial treatment in a critically ill patient with infection. The current review delves on these nuances with a focus on PK-PD for optimized use of antimicrobials in a critically ill patient.

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Section: A Renal Replacement Therapy (Rrt)mentioning

confidence: 99%

Clinical Pharmacokinetics and dose optimization of anti-infectives in critical care: A narrative review

Bhandari

Rohilla

Shafiq

et al. 2023

Preprint

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“…Stefan Weiler et al. (101) of Innsbruck Medical University, Innsbruck, Austria assessed the pharmacokinetics of teicoplanin (TP) in a patient during AD. After a 1200 mg loading dose (24 mg/kg), doses of 1200 and 1000 mg (20 mg/kg) on day 2 and 3, respectively, were administered during two cycles of AD.…”

Section: Liver Supportmentioning

confidence: 99%

Artificial Organs 2011: A Year in Review

Malchesky¹

2012

Artificial Organs

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In this Editor's Review, articles published in 2011 are organized by category and briefly summarized. As the official journal of The International Federation for Artificial Organs, The International Faculty for Artificial Organs, and the International Society for Rotary Blood Pumps, Artificial Organs continues in the original mission of its founders "to foster communications in the field of artificial organs on an international level."Artificial Organs continues to publish developments and clinical applications of artificial organ technologies in this broad and expanding field of organ replacement, recovery, and regeneration from all over the world. We take this time also to express our gratitude to our authors for offering their work to this journal. We offer our very special thanks to our reviewers who give so generously of time and expertise to review, critique, and especially provide meaningful suggestions to the author's work whether eventually accepted or rejected. Without these excellent and dedicated reviewers, the quality expected from such a journal would not be possible. We also express our special thanks to our Publisher, Wiley-Blackwell, for their expert attention and support in the production and marketing of Artificial Organs. In this Editor's Review, that historically has been widely well-received by our readership, we aim to provide a brief reflection of the currently available worldwide knowledge that is intended to advance and better human life while providing insight for continued application of technologies and methods of organ replacement, recovery, and regeneration. We look forward to recording further advances in the coming years.

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