Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study

Venditti, Mario; Tarasi, A.; Capone, Alessandro; M, Galiè; Menichetti, F.; Martino, Pietro; Serra, Pietro

doi:10.1093/jac/40.3.449

Cited by 20 publications

(7 citation statements)

References 8 publications

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“…Teicoplanin plus gentamicin, both administered once a day, could be an alternative therapeutic approach for selected cases of enterococcal endocarditis on an outpatient basis, probably after 2 weeks of treatment in the hospital environment. Our experimental results showed that teicoplanin plus gentamicin, both administered once a day by means of a controlled infusion pump system to mimic human kinetics, was as effective as the elective treatment with ampicillin at 2 g/4 h plus gentamicin at 1 mg/kg/8 h. The results from a recent clinical study by Venditti et al (38) provide evidence that a single daily dose of teicoplanin plus gentamicin could be a good therapeutic option for home treatment of selected cases of enterococcal endocarditis. Six patients with enterococcal endocarditis were cured when treated with teicoplanin in combination with gentamicin or netilmicin administered once a day.…”

Section: Discussionmentioning

confidence: 55%

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Efficacy of Teicoplanin-Gentamicin Given Once a Day on the Basis of Pharmacokinetics in Humans for Treatment of Enterococcal Experimental Endocarditis

López

Gavaldá

Martín

et al. 2001

Antimicrob Agents Chemother

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With the aim of investigating home therapy for enterococcal endocarditis, we compared the efficacy of teicoplanin combined with gentamicin given once a day or in three daily doses (t.i.d.) with the standard treatment, ampicillin plus gentamicin administered t.i.d., for treating experimental enterococcal endocarditis. The antibiotics were administered by using "human-like pharmacokinetics" (H-L), i.e, pharmacokinetics like those in humans, that simulated the profiles of these drugs in human serum. Animals with catheter-induced endocarditis were infected intravenously with 10 8 CFU of Enterococcus faecalis EF91 (MICs and MBCs of ampicillin, gentamicin, and teicoplanin, 0.5 and 32, 16 and 32, and 0.5 and 1 g/ml, respectively) and were treated for 3 days with ampicillin H-L at 2 g every 4 h plus gentamicin H-L at 1 mg/kg every 8 h, or teicoplanin H-L at 10 mg/kg every 24 h, alone or combined with gentamicin, administered at dose of H-L at 1 mg/kg every 8 h or H-L at 4.5 mg/kg every 24 h. The results of therapy for experimental endocarditis due to EF91 showed that teicoplanin alone was as effective as ampicillin alone in reducing the bacterial load (P > 0.05). The combination of ampicillin or teicoplanin with gentamicin was more effective than the administration of both drugs alone in reducing the log 10 CFU/gram of aortic vegetation (P < 0.01 and P < 0.05, respectively). Teicoplanin plus gentamicin H-L at 4.5 mg/kg, both administered every 24 h, showed an efficacy equal to the "gold standard," ampicillin plus gentamicin H-L at 1 mg/kg t.i.d. (P > 0.05). Increasing the interval of administration of gentamicin to a single daily dose combined with teicoplanin resulted in a reduction of bacteria in the vegetations equivalent to that achieved with the recommended regimen of ampicillin plus thrice-daily gentamicin in the treatment of experimental endocarditis due to E. faecalis. Teicoplanin plus gentamicin, both administered once a day, may be useful home therapy for selected cases of enterococcal endocarditis.

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Section: Discussionmentioning

confidence: 55%

“…Martino et al (27) treated four patients; three of them were cured, and one relapsed and was cured with surgery plus treatment with ampicillin and gentamicin. A 4-week course of 10 mg/kg/day has been found to be effective against native streptococcal endocarditis (38). Presterl et al (33) treated and cured five patients.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Teicoplanin-Gentamicin Given Once a Day on the Basis of Pharmacokinetics in Humans for Treatment of Enterococcal Experimental Endocarditis

López

Gavaldá

Martín

et al. 2001

Antimicrob Agents Chemother

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“…Dawka nasycająca pełni zasadniczą rolę, ponieważ lek wią-że się łatwo z białkami krwi (≥ 98%) i powoli penetruje do wegetacji [140]. Jednak tylko w ograniczonej liczbie badań retrospektywnych oceniano skuteczność teikoplaniny w IZW spowodowanym paciorkowcami [141] i enterokokami [142].…”

Section: Grupa Wrażliwych Na Penicylinę Paciorkowców Jamy Ustnej Orazunclassified

“…Grupa szczepów w pełni opornych wciąż się powiększa. W raportach oceniających dużą liczbę próbek częstość wystę-powania szczepów Streptococcus mitis i Streptococcus oralis o względnej i pełnej oporności oceniano na ponad 30% [142,143]. Odwrotnie, ponad 99% paciorkowców pokarmowych pozostaje wrażliwych na penicylinę.…”

Section: Grupa Opornych Na Penicylinę Paciorkowców Jamy Ustnej Oraz Sunclassified

2015 ESC Guidelines for the management of infective endocarditis

Habib¹,

Lancellotti

Antunes³

et al. 2015

Kardiol Pol

144

212

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“…Recent large strain collections report .30% of relatively and fully resistant S. mitis and S. oralis. 118,119 Conversely, .99% of group D streptococci remain penicillin susceptible. Treatment guidelines for penicillin-resistant streptococcal IE rely on retrospective series.…”

Section: Penicillin-resistant Oral Streptococci and Group D Streptococcimentioning

confidence: 99%

Indoor Navigation for a Humanoid Robot Using a View Sequence

Ido

Shimizu

Matsumoto

et al. 2009

The International Journal of Robotics Research

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Humanoid robots are expected to work in the human environment due to their similarity to the human shape, and they are required to achieve localization and navigation autonomously. In this paper, indoor navigation is realized based on a view-based approach using a camera mounted on the head. In the case of a humanoid robot, image blur and swing due to walking is a crucial issue for image matching during localization. The quantitative effect of walking on the image is firstly investigated by utilizing a motion capture system. Then a method to generate a stable view sequence is proposed based on the detection of optical flows. The navigation function with the proposed method was implemented on a humanoid robot HRP-2, and the effectiveness was confirmed by indoor walking experiments.

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Teicoplanin in the treatment of enterococcal endocarditis: clinical and microbiological study

Cited by 20 publications

References 8 publications

Efficacy of Teicoplanin-Gentamicin Given Once a Day on the Basis of Pharmacokinetics in Humans for Treatment of Enterococcal Experimental Endocarditis

Efficacy of Teicoplanin-Gentamicin Given Once a Day on the Basis of Pharmacokinetics in Humans for Treatment of Enterococcal Experimental Endocarditis

2015 ESC Guidelines for the management of infective endocarditis

Indoor Navigation for a Humanoid Robot Using a View Sequence

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