Teichoic Acids in the Walls of Staphylococci : Serological Investigations on Teichoic Acids from the Walls of Staphylococci

Davison, Andrew S.; Baddiley, J.; Hofstad, Tor; Losnegard, Norvald; Oeding, Per

doi:10.1038/202872a0

Cited by 42 publications

(11 citation statements)

References 14 publications

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“…In the case of LTA, antibodies to the poly(Gro-P) moiety (264,499) and glycosyl substituents (241) have all been detected. Good correlation with the type of TA and the serological specificity of lactobacilli and staphylococci provided a useful means of classifying these genera (41,116). Antibodies in rabbits to the D-alanyl esters of TA were also detected (252,322,336).…”

Section: Role In Virulencementioning

confidence: 95%

A Continuum of Anionic Charge: Structures and Functions ofd-Alanyl-Teichoic Acids in Gram-Positive Bacteria

Neuhaus

Baddiley

2003

Microbiol Mol Biol Rev

901

1,097

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SUMMARY Teichoic acids (TAs) are major wall and membrane components of most gram-positive bacteria. With few exceptions, they are polymers of glycerol-phosphate or ribitol-phosphate to which are attached glycosyl and d-alanyl ester residues. Wall TA is attached to peptidoglycan via a linkage unit, whereas lipoteichoic acid is attached to glycolipid intercalated in the membrane. Together with peptidoglycan, these polymers make up a polyanionic matrix that functions in (i) cation homeostasis; (ii) trafficking of ions, nutrients, proteins, and antibiotics; (iii) regulation of autolysins; and (iv) presentation of envelope proteins. The esterification of TAs with d-alanyl esters provides a means of modulating the net anionic charge, determining the cationic binding capacity, and displaying cations in the wall. This review addresses the structures and functions of d-alanyl-TAs, the d-alanylation system encoded by the dlt operon, and the roles of TAs in cell growth. The importance of dlt in the physiology of many organisms is illustrated by the variety of mutant phenotypes. In addition, advances in our understanding of d-alanyl ester function in virulence and host-mediated responses have been made possible through targeted mutagenesis of dlt. Studies of the mechanism of d-alanylation have identified two potential targets of antibacterial action and provided possible screening reactions for designing novel agents targeted to d-alanyl-TA synthesis.

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Section: Role In Virulencementioning

confidence: 95%

A Continuum of Anionic Charge: Structures and Functions ofd-Alanyl-Teichoic Acids in Gram-Positive Bacteria

Neuhaus

Baddiley

2003

Microbiol Mol Biol Rev

901

1,097

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“…In the species Staphylococcus aureus the polymer is of the ribitol type with aand p-N-acetylglucosamine residues (Baddiley, Buchanan, RajBhandary & Sanderson, 1962)~ whereas in the species S. epidermidis it is of the glycerol type with glucose residues (Davison & Baddiley,I 964). Immunochemical specificity of these teichoic acids is related to differences in glycosidic configuration (Davison, Baddiley, Hofstad, Losnegard & Oeding, 1964;Nathenson, Ishimoto, Anderson & Strominger, 1966 ; Oeding, Myklestad & Davison, 1967). In strains of S. lactis no similar homogeneity in type of teichoic acid is found, and one strain (13) contains a polymer of glycerol phosphate and N-acetylglucosamine I -phosphate, that has been extensively studied (Archibald, Baddiley & Button, 1965 …”

Section: Introductionmentioning

confidence: 99%

The Wall Composition of Micrococci

Baddiley¹,

Brock²,

Davison³

et al. 1968

Journal of General Microbiology

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SUMMARYThe distribution of teichoic acids and extractable polysaccharides in the walls of the various micrococci examined did not show a direct correlation with the conventional systematic classification of these organisms. Three main groups were distinguished : in one group (A) ribitol teichoic acids containing glucosamine were found; in a second group (B) glycerol teichoic acids with a variety of sugar substituents were found; in a third group (C) wall teichoic acids were absent but polysaccharides were extracted from the walls. The third group (C) represents the species Micrococcus conglomeratus, and the lack of order in the structure of the extractable polysaccharides supports previous criticism of the validity of this species.

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“…These and the samples received from Baddiley were now compared to Hofstad's system on agar gel diffusion. It was shown that Hofstad's polysaccharide 263 line corresponded to the alpha-glucosamine linkage of the teichoic acid preparations (Davison et al, 1964).…”

Section: Group Specificmentioning

confidence: 99%

Antigenic Properties of Staphylococci

Oeding

1965

Annals of the New York Academy of Sciences

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Teichoic Acids in the Walls of Staphylococci : Serological Investigations on Teichoic Acids from the Walls of Staphylococci

Cited by 42 publications

References 14 publications

A Continuum of Anionic Charge: Structures and Functions ofd-Alanyl-Teichoic Acids in Gram-Positive Bacteria

A Continuum of Anionic Charge: Structures and Functions ofd-Alanyl-Teichoic Acids in Gram-Positive Bacteria

The Wall Composition of Micrococci

Antigenic Properties of Staphylococci

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