Tei-Index in patients with mild-to-moderate congestive heart failure

Bruch, Christian; Schmermund, Axel; Marin, D.; Katz, M; Bartel, Thomas; Schaar, Johannes A.; Erbel, Raimund

doi:10.1053/euhj.2000.2246

Cited by 247 publications

(221 citation statements)

References 19 publications

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“…Peak E and A heights were determined on mitral valve sequential waveforms in at least 5 waveforms. The mean performance index was calculated as the isovolumetric contraction time (ICT) plus the isovolumetric relaxation time (IRT) divided by the ejection time ([ICT+IRT]/ET) to determine if either systolic or diastolic dysfunction was present 21, 22, 23, 24, 25. Doppler measurement data represent 3 to 6 averaged cardiac cycles from at least 2 scans per mouse.…”

Section: Methodsmentioning

confidence: 99%

Modeling the Transition From Decompensated to Pathological Hypertrophy

Pascual

Schisler

Grevengoed

et al. 2018

JAHA

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BackgroundLong‐chain acyl‐CoA synthetases (ACSL) catalyze the conversion of long‐chain fatty acids to fatty acyl‐CoAs. Cardiac‐specific ACSL1 temporal knockout at 2 months results in a shift from FA oxidation toward glycolysis that promotes mTORC1‐mediated ventricular hypertrophy. We used unbiased metabolomics and gene expression analyses to examine the early effects of genetic inactivation of fatty acid oxidation on cardiac metabolism, hypertrophy development, and function.Methods and ResultsGlobal cardiac transcriptional analysis revealed differential expression of genes involved in cardiac metabolism, fibrosis, and hypertrophy development in Acsl1 H−/− hearts 2 weeks after Acsl1 ablation. Comparison of the 2‐ and 10‐week transcriptional responses uncovered 137 genes whose expression was uniquely changed upon knockdown of cardiac ACSL1, including the distinct upregulation of fibrosis genes, a phenomenon not observed after complete ACSL1 knockout. Metabolomic analysis identified metabolites altered in hearts displaying partially reduced ACSL activity, and rapamycin treatment normalized the cardiac metabolomic fingerprint.ConclusionsShort‐term cardiac‐specific ACSL1 inactivation resulted in metabolic and transcriptional derangements distinct from those observed upon complete ACSL1 knockout, suggesting heart‐specific mTOR (mechanistic target of rapamycin) signaling that occurs during the early stages of substrate switching. The hypertrophy observed with partial Acsl1 ablation occurs in the context of normal cardiac function and is reminiscent of a physiological process, making this a useful model to study the transition from physiological to pathological hypertrophy.

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Section: Methodsmentioning

confidence: 99%

Modeling the Transition From Decompensated to Pathological Hypertrophy

Pascual

Schisler

Grevengoed

et al. 2018

JAHA

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“…15) Furthermore, the Tei index has the advantages of being less affected by age, heart rate, and preload than conventional Doppler measurements, [16][17][18] and the index has an excellent reproducibility. 6,13,19,20) The Tei index is found to be very reliable and has a predictor role not only in MI, but also in other cardiac pathologies such as dilated cardiomyopathy, primary pulmonary hypertension, cardiac amyloidosis, and aortic stenosis as well. [21][22][23] Vol 47 No 3 Thirteen of 77 in our patient group died and 22 had CHF.…”

Section: Discussionmentioning

confidence: 99%

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

Uzunhasan

Okçun

et al. 2006

Int. Heart J.

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SUMMARYThe Tei index is an echocardiographic index of combined systolic and diastolic function, calculated as isovolumetric relaxation time plus isovolumetric contraction time divided by ejection time. The aim of this study was to define the correlation of the Tei index with left ventricular dilatation and mortality in patients with acute myocardial infarction (AMI).A total of 77 patients (58 men, 19 women) with a mean age of 53 ± 12 years, who had presented with an AMI in our clinic between June 2001 and February 2002 were compared with a control group of 88 healthy subjects (63 men, 25 women) with a mean age of 55 ± 6 years. Echocardiographic evaluation was carried out within 24 hours and the third month of AMI, using a 3.5 MHz probe with pulse wave Doppler recordings by the adult cardiac mode of an Acuson C 256 echocardiograph.There were statistically significant differences between the 2 groups in all echocardiographic parameters, except mitral A wave. Thirteen patients died during the follow-up period of 3 months. The Tei index was significantly higher in the patients who died compared with those who survived (0.70 ± 0.10 versus 0.61 ± 0.10; P < 0.001). The patients who had heart failure after AMI had a mean Tei index value of 0.76 ± 0.27, whereas the patients who did not have heart failure after AMI had a significantly lower Tei index value of 0.60 ± 0.32 (P < 0.05). Patients were divided into 2 groups according to their Tei index. Patients with a > 0.60 Tei index had significantly higher end-systolic and enddiastolic volumes compared to patients with a < 0.60 Tei index (P < 0.001 for both) in the acute phase of AMI. Within 3 months, patients with a Tei index < 0.60 had a significant reduction in end-diastolic volumes (P < 0.01), whereas the end-diastolic volumes did not change significantly in patients with an index > 0.60 (P = 0.19).The Tei index is an important indicator of left ventricular dysfunction and death after AMI. A greater Tei index at the onset of AMI is associated with a higher incidence of subsequent cardiac death, CHF, and progressive LV remodeling. (Int Heart J 2006; 47: 331-342)

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“…TDI can be used to calculate the IVCT and IVRT over a single cardiac cycle under normal conditions [2,3,14]. In addition, TDI provides the timing elements necessary to cal- culate IVRT on a beat-to-beat basis [3,14].…”

Section: Discussionmentioning

confidence: 99%

The Relationship between Invasive Hemodynamic Measurements and Tissue Doppler-Derived Myocardial Velocity and Acceleration during Isovolumic Relaxation in Healthy Dogs

Hori

Kunihiro

Kanai

et al. 2009

The Journal of Veterinary Medical Science

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ABSTRACT. This study investigated the feasibility of using the values of tissue Doppler imaging (TDI)-derived myocardial velocity during isovolumic relaxation (V IR ) and myocardial acceleration during isovolumic relaxation (ACC) obtained from the left ventricular (LV) free wall to evaluate LV relaxation in normal dogs. Seven dogs were anesthetized, and dobutamine or esmolol was infused at a rate of 5.0 and 10.0 g/kg/min or 100 and 500 g/kg/min, respectively, via a cephalic vein. The order of drug administration (dobutamine or esmolol) was assigned to each dog. Simultaneous pulsed-Doppler (PD) echocardiography, TDI and hemodynamic measurements were performed. Compared with the baseline values, dobutamine significantly increased dP/dt min, but significantly shortened tau (). Similarly, esmolol significantly decreased dP/dt min, but significantly prolonged . Compared with the baseline values, dobutamine significantly increased V IR and ACC, and esmolol significantly decreased V IR and ACC. Both dP/dt min and  were significantly correlated with TDI-derived IVRT (r=-0.43 and 0.74), V IR (r=0.85 and -0.49) and ACC (r=0.84 and -0.52). These results indicate that the TDIderived V IR and ACC values obtained from the LV free wall can potentially be used to assess LV relaxation in dogs.KEY WORDS: canine, diastolic function, left ventricle, tissue Doppler imaging.

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Tei-Index in patients with mild-to-moderate congestive heart failure

Abstract: The Tei-Index is a sensitive indicator of overall cardiac dysfunction in patients with mild-to-moderate congestive heart failure. The Tei-Index is easily obtained and may be used in the work-up of patients with suspected cardiac dysfunction.

Cited by 247 publications

References 19 publications

Modeling the Transition From Decompensated to Pathological Hypertrophy

Modeling the Transition From Decompensated to Pathological Hypertrophy

Correlation of the Tei Index With Left Ventricular Dilatation and Mortality in Patients With Acute Myocardial Infarction

The Relationship between Invasive Hemodynamic Measurements and Tissue Doppler-Derived Myocardial Velocity and Acceleration during Isovolumic Relaxation in Healthy Dogs

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