Tegumental Alterations on Raillietina galli, an Intestinal Parasite of Fowl, after Treatment with Millettia taiwaniania Extract

Lalchhandama, Kholhring

doi:10.17582/journal.aavs/2019/7.11.1010.1014

Cited by 4 publications

(3 citation statements)

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“…β-amyrin, another ubiquitous triterpenoid identified in this study, possesses antibacterial [28], antinociceptive [29], anti-inflammatory [30], antihyperglycemic, and hypolipidemic [31] properties. Raillietina species are common and abundant helminth parasites of fowl and are, thereby, convenient laboratory models in anthelmintic susceptibility tests because of their availability and ease of maintenance in culture media [23,32]. These tapeworms have typical cestode features, including flat, segmented bodies.…”

Section: Discussionmentioning

confidence: 99%

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Antiparasitic activity of the steroid-rich extract of Schima wallichii against poultry cestode

Lalthanpuii,

Lalchhandama

2024

Vet World

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Background and Aim: Schima wallichii Korth., commonly known as the needlewood tree (family Theaceae) has therapeutic uses in traditional Mizo medicine for human helminthiasis and serves as a balm against ectoparasites in animals. Although the medicinal properties have been studied experimentally, its use as a traditional anthelmintic remains unexplored. This study aimed to analyze the chemical components and antiparasitic activity of S. wallichii. Materials and Methods: The chemical analysis of S. wallichi bark extracts was conducted focusing on the secondary metabolites using petroleum ether, chloroform, and methanol. Gas chromatography-mass spectrometry (GC-MS) was used to identify the specific compounds. An anthelmintic susceptibility test was carried out against Raillietina tetragona, intestinal cestode parasite of fowl. Results: The methanol extract yielded the highest concentrations of alkaloids, carbohydrates, glycosides, sterols, saponins, and tannins among all the extracts. Sterols were the most abundant compounds in all extracts, with flavonoids being absent. Secondary metabolites were largely absent in the petroleum ether and chloroform extracts. The GC-MS data identified cholest-22-ene-21-ol as the major steroid component. The cestode parasite was inhibited in a concentration-dependent manner by the plant extract. The plant extract’s anthelmintic activity was evident through observable damage to the parasite’s outer structure. Conclusion: Phytosterols in S. wallichii bark are responsible for its anthelmintic properties. The mechanism and pharmaceutical properties of the anthelmintic molecule require further exploration. Keywords: anthelmintic, cestode, medicinal plant, parasite, scanning electron microscopy.

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Section: Discussionmentioning

confidence: 99%

“…Raillietina species are common and abundant helminth parasites of fowl and are, thereby, convenient laboratory models in anthelmintic susceptibility tests because of their availability and ease of maintenance in culture media [ 23 , 32 ]. These tapeworms have typical cestode features, including flat, segmented bodies.…”

Section: Discussionmentioning

confidence: 99%

Antiparasitic activity of the steroid-rich extract of Schima wallichii against poultry cestode

Lalthanpuii,

Lalchhandama

2024

Vet World

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“…Also, the extract of Acacia caesia stem bark (20 mg/ml) has been found to possess distinct anthelmintic activity against the tapeworm Raillietina tetragona [23]. The methanol extract of Millettia taiwaniana roots are also known to possess significant anthelmintic activity at 20 mg/ml against intestinal tapeworms Taenia tetragona and Raillietina galli [24,25]. Likewise, the chloroform extract of Imperata cylindrica roots have exhibited anthelmintic activity against R. tetragona and A. galli [26].…”

Section: Medicinal Plants Used In the Traditional Medicine System 21 Parasitic Infectionsmentioning

confidence: 99%

A Traditional and Pharmacological Approach of Medicinal Plants in Mizoram, India

Soren¹,

Lalthanpuii²

2022

Natural Drugs From Plants

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Traditional medicine is the sole method of treatment in rural India even today. Several communities practice their traditional method of treatment and are not affected by the advances in modern medicine. The tribal communities prefer to use and consult their own traditional practitioners since these are easily available, accessible and cheap. It is also believed that these are free of side effects and very effective. The Mizos of the north-eastern state of India (Mizoram), use several plants to treat various ailments. Their practices are unique and are usually carried out by elderly persons of the community or traditional healers. Several plants used in their traditional medicine have been scientifically validated for their efficacy and toxicity studies. However, a large number still awaits identification and efficacy validations. This manuscript describes both the studied and untouched medicinal plants used in the traditional medicine system of the Mizos of Mizoram. Although, several other remedies are yet to be discovered, this study has described most of them in current use.

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In vitro anthelmintic efficacy of Ferulic and Sinapic acid against zoonotic cestode Hymenolepis diminuta (Rudolphi, 1819)

Saha,

Mondal,

Mandal

et al. 2024

J Parasit Dis

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The present study is aimed to investigate potential in vitro anthelmintic e cacy of two phenolic compounds Ferulic acid and Sinapic acid against the parasite Hymenolepis diminuta. Adult parasites collected from infected rat's intestine (maintained in our laboratory) were treated with 1, 2.5, 5, 10 and 20 mg/mL concentrations of both the compounds in RPMI-1640 media containing 1% Tween 20. Further, one group was treated in Praziquantel as a reference drug and another group of parasites were kept as control. The e cacy was evaluated on the basis of motility and mortality of the parasites. The paralyzed worms were further processed for the morphological and ultrastructural studies and observed through light and scanning electron microscopy. A signi cant dose-dependent e cacy was found in all treatment and decrease in relative movability value was also recorded in all the concentrations of two compounds treated parasites. The time taken for paralysis in 5 mg/mL of Ferulic acid and 10 mg/mL of Sinapic acid were 1.47 ± 0.04 hours and 0.88 ± 0.03 hours respectively which is accorded with the standard concentration of Praziquantel. Morphological micrographs revealed pronounced distortion and altered topography of scolex and tegument while histological study showed loss of uniform tegumental integrity with folds and cracks in the treated parasites. Further, extensive alteration in the scolex and irrevocable disruption all over the body surface with loss of trapezoid shape, shrinkage of tegument and sloughing off microtriches were observed in electron microscopic study. The study indicated that both the compounds possess strong activity against H. diminuta and further studies are required to understand their detailed mode of action to exploit them as potential alternative candidates for curing helminthiases.

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Tegumental Alterations on Raillietina galli, an Intestinal Parasite of Fowl, after Treatment with Millettia taiwaniania Extract

Abstract: It was previously reported that M. taiwaniana root bark extract had anthelmintic activity by causing dosedependent efficacy on poultry tapeworm (Roy et al., 2008),

Cited by 4 publications

References 5 publications

Antiparasitic activity of the steroid-rich extract of Schima wallichii against poultry cestode

Antiparasitic activity of the steroid-rich extract of Schima wallichii against poultry cestode

A Traditional and Pharmacological Approach of Medicinal Plants in Mizoram, India

In vitro anthelmintic efficacy of Ferulic and Sinapic acid against zoonotic cestode Hymenolepis diminuta (Rudolphi, 1819)

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