Teenage obesity in relation to breast cancer risk

Ba, Schölkens

doi:10.1038/sj.ijo.0800769

Cited by 67 publications

(62 citation statements)

References 57 publications

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“…The latter observation may be due to the fact that in premenopausal women, who are naturally oestrogenized, anovulation due to obesity results in a decrease in oestrogen and progesterone production. [30][31][32] Moreover, in a study on Several anthropometric measurements and breast cancer risk B Tehard et al premenopausal obese women, Potischman et al 29 noted that injected radiolabelled oestrogen was sequestered by adipose tissue, reducing levels of free oestradiol. A global decrease in ovarian activity and oestrogen storage due to obesity would lead to a decreased risk of premenopausal breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Téhard

Clavel‐Chapelon

2005

Int J Obes

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Objective: To investigate the association between various anthropometric characteristics and breast cancer. Design: Longitudinal prospective cohort study. Follow-up between 1995 and 2000. Subjects: In total, 69 116 women (age: 45-70 years; mean follow-up: 3.6 years), 275 premenopausal and 860 postmenopausal incident invasive breast cancers. Measurements: Self-reported height, weight, breast, thorax, waist and hip circumferences and calculated body mass index (BMI) and waist-to-hip ratio (WHR) at baseline. Results: A slight increase in risk with increasing height was found. Weight, BMI, thorax and waist circumferences and WHR were negatively related to breast cancer risk among premenopausal women. The relationships became non significant after additional adjustment for BMI. An increased risk of premenopausal breast cancer with an android body shape (WHR40.87) might possibly be confined to obese women. Among postmenopausal women, all anthropometric measurements of corpulence were positively associated with breast cancer risk but became non significant after additional adjustment for BMI. No difference in risk of postmenopausal breast cancer according to HRT use was observed.

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Section: Discussionmentioning

confidence: 99%

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Téhard

Clavel‐Chapelon

2005

Int J Obes

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“…Neither adult body mass index nor waist-to-hip ratio modified the effect of perceived adolescent weight on breast cancer risk. The biological mechanism that Stoll (1998) proposed to help explain the reduced risk of premenopausal breast cancer associated with adolescent obesity in some studies was that obesity triggered a hyperinsulinemic insulin resistance at puberty that could lead to abnormal ovarian steroidogenesis and anovulation. Most of the women in this study grew up during a period when food and meat were rationed and adolescent obesity was rare, thus perceived weight at the age of 15 may not reflect adolescent obesity as defined among Western women.…”

Section: Discussionmentioning

confidence: 99%

Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population

et al. 2002

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We assessed breast cancer risk in relation to weight at birth and adolescence. In-person interviews were completed with the biological mothers of women aged 45 years and younger who participated in the Shanghai Breast Cancer Study in 1996 -98 (288 cases, 350 controls). After adjustment for confounding, women who were 4000 g or more at birth were not at increased risk of breast cancer (odds ratio=0.7; 95% confidence interval 0.4 -1.4) relative to women whose birth weight was 2500 -2999 g. Compared with women of average perceived weight at age 15 years, no relation was apparent for heavier than average weight based on maternal report (odds ratio=0.7; 95% confidence interval 0.5 -1.2) or self-report (odds ratio=1.0; 95% confidence interval 0.7 -1.6). Perceived adolescent weight and height did not modify the association of birth weight with breast cancer risk. These results suggest that weight early in life is not related to premenopausal breast cancer risk in this low-risk population. (Ekbom et al, 1992;Innes et al, 2000;Michels et al, 1996;Sanderson et al, 1996). Conversely, high adolescent (Coates et al, 1999;Hislop et al, 1986;Le Marchand et al, 1988a), early adult (Coates et al, 1999;Huang et al, 1997;Trentham-Dietz et al, 1997) and adult weight or body mass index (Brinton and Swanson, 1992;Huang et al, 1997;Swanson et al, 1996;Ursin et al, 1995;van den Brandt et al, 2000) appear to be protective against premenopausal breast cancer. Several studies have investigated the association between breast cancer and weight at birth (De Stavola et al, 2000;Ekbom et al, 1992Ekbom et al, , 1997Innes et al, 2000;Le Marchand et al, 1988b;Michels et al, 1996;Sanderson et al, 1996Sanderson et al, , 1998a or weight at adolescence (Brinton and Swanson, 1992;Choi et al, 1978;Coates et al, 1999;Franceschi et al, 1996;Hislop et al, 1986;Le Marchand et al, 1988a;Pryor et al, 1989) with inconsistent findings. Possible limitations of these studies related to exposure measurement and age at diagnosis of breast cancer.Since self-report of body size in early life is prone to misclassification, maternal report may be less subjective. Maternal report was available for two of the studies investigating breast cancer risk associated with birth weight (Michels et al, 1996;Sanderson et al, 1998a), but none of the studies of adolescent weight. The present analysis was conducted to assess whether birth weight and adolescent weight as reported by subjects' mothers were related to premenopausal breast cancer risk. In addition, we investigated whether perceived adolescent weight and height modified the association of birth weight with breast cancer risk. MATERIALS AND METHODSDetailed methods of this population-based case -control study appear elsewhere (Gao et al, 2000). Briefly, all women aged 25 -64 years who were permanent residents of urban Shanghai at the time of diagnosis of first primary invasive breast cancer (August 1996 through March 1998) were eligible for the study. Two senior pathologists histologically confirmed all diagnoses. We used...

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“…We observed larger differences for PR+ (RR, 0.90) versus PRÀ (RR, 0.62) tumors, however, which is inconsistent with the finding of no differences in progesterone concentrations noted above. Obese adolescent and preadolescent girls also have elevated levels of insulin and insulin-like growth factor I, and this leads to impaired ovarian steroid metabolism and anovulation (35).…”

Section: Discussionmentioning

confidence: 99%

Relative Weight at Age 12 and Risk of Postmenopausal Breast Cancer

Bardia¹,

Vachon²,

Olson³

et al. 2008

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Early adolescent weight may affect the risk of postmenopausal breast cancer, and this association may be modified by a family history of breast or ovarian cancer in a first-degree relative, and/or estrogen (ER) and progesterone (PR) receptor status of the disease. Methods: Relative weight at age 12 years (above, below, or average weight compared with peers) and family history were ascertained using a mailed questionnaire in 1986, in the Iowa Women's Health Study, a prospective cohort study of postmenopausal women. Incident breast cancer cases (including ER and PR status) were identified using the Iowa Surveillance, Epidemiology, and End Results Cancer Registry. Relative risks (RR) and 95% confidence intervals (95% CI) were estimated using Cox proportional hazards regression, and were adjusted for breast cancer risk factors, including body mass index at age 18 years and body mass index at study baseline.

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Teenage obesity in relation to breast cancer risk

Cited by 67 publications

References 57 publications

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Several anthropometric measurements and breast cancer risk: results of the E3N cohort study

Weight at birth and adolescence and premenopausal breast cancer risk in a low-risk population

Relative Weight at Age 12 and Risk of Postmenopausal Breast Cancer

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