Tectal CRFR1 receptors modulate food intake and feeding behavior in the South African clawed frog Xenopus laevis

Prater, Christine M.; Harris, Breanna N.; Carr, James A.

doi:10.1016/j.yhbeh.2018.07.013

Cited by 9 publications

(1 citation statement)

References 69 publications

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“…Hotta et al (1999) showed that brain CRF is involved in the inhibition of feeding behavior and modulation of locomotor activity in emotional stress through CRFR1 [35]. Upon activation, CRFR1 can inhibit the feed intake of young Xenopus laevis [36]. However, Stengel et al (2014) showed that the CRF-CRFR2 system is the primary signaling pathway that mediates the anorexigenic effect of CRF [32].…”

Section: A C C E P T E D a R T I C L Ementioning

confidence: 99%

Effects of intracerebroventricular injection of corticotrophin releasing factor on the gene expression of ghrelin and corticotrophin releasing factor receptors in broiler chickens

Cai

Song²

2022

Anim Biosci

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Objective: This study aimed to investigate the effects of corticotropin-releasing factor (CRF) on the feed intake of broiler chickens and explore its influencing mechanism. Methods:The study included two trials. In trial 1, 32 male broiler chickens (Arbor Acres, Gallus gallus domesticus) were ventricle buried tubes, and they were allowed to recover for 3 days. At 8:00 AM, intracerebroventricular (ICV) injection with CRF or normal saline was performed in 10-day-old broiler chickens, which were divided into the 5, 10, and 20 µg and control (normal saline) groups according to the dose of CRF injection. In trial 2, chickens were divided into the 10 µg and control group (physiological saline) to repeat trial 1.Results: Results of trial 1 showed that the cumulative amount of feed intake in the 10 or 20 µg groups was considerably lower than that of the control group after ICV injection with CRF. The lowest amount of feed intake was obtained with the addition of 10 µg of CRF. In trial 2, the expression of ghrelin in the hypothalamus injected with 10 µg of CRF increased significantly, but the expression of ghrelin in various sections of the small intestine considerably decreased. The expression of CRF receptor subtypes 1 (CRFR1) in the hypothalamus and some parts of the small intestine remarkably increased, and the expression of CRF receptor subtypes 2 (CRFR2) increased only in the duodenum, whereas the expression of growth hormone secretagogue receptor (GHSR-1α) in the jejunum and ileum increased considerably after ICV injection of 10 µg of CRF. Conclusion:The CRF at 10 µg increased ghrelin expression in the hypothalamus and CRFR1 expression in the small intestine, and this phenomenon was related to the suppressed feed intake of broiler chickens.

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