Tecovirimat Treatment for Monkeypox Virus Keratouveitis

Abstract

This case report describes tecovirimat treatment for a patient with monkeypox virus–related keratouveitis.

Severe Corneal Involvement Associated With Mpox Infection

“…During the 2022 mpox outbreak, corneal infection seems rare occurring in 2 of 588 patients with mpox (0.3%) at our infectious disease unit between May and October and in 4 of 26577 mpox cases in the US . Only 4 cases have been reported in the literature:1 geographic ulcer, 1 serpiginous linear centripetal keratitis, and 2 undescribed cases . Our cases suggest that arcuate serpiginous centripetal epithelial keratitis, as described by Finamor et al, is specific to mpox.…”

“…Only 4 cases have been reported in the literature:1 geographic ulcer, 1 serpiginous linear centripetal keratitis, and 2 undescribed cases . Our cases suggest that arcuate serpiginous centripetal epithelial keratitis, as described by Finamor et al, is specific to mpox. We have not observed such a pattern in other viral diseases.…”

Spectrum of ophthalmic manifestations in monkeypox virus infection worldwide: Systematic review and meta-analysis

“…He developed a skin rash affecting his trunk, limbs, and genitalia within the previous week. Finamor (2022) [ 42 ] Brazil Case report 1 27 y, male PCR Diffuse anterior scleritis, serpiginous epithelial elevation in the corneal periphery with an underlying whitish stromal infiltrate and thinned out epithelium. Decreased corneal sensitivity was observed.…”

“…Four case reports described anterior uveitis [ 34 , 36 , 42 , 43 ]. All had mild inflammation (0.5 or 1+ of cells) and were accompanied by corneal compromise.…”

“…All had mild inflammation (0.5 or 1+ of cells) and were accompanied by corneal compromise. Two had keratic precipitates [ 34 , 42 ], and one had keratitis with epithelial corneal ulcer and superior limbitis [ 43 ]. For more detailed information regarding the frequency of uveitis by type of study, see Table 2 .…”