Technology: The $1,000 genome

Hayden, Erika Check

doi:10.1038/507294a

Cited by 372 publications

(135 citation statements)

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“…This step change in scale enables us to offer genetic testing to many more people and test one person for hundreds or thousands of genes at a time 1. Indeed, while the initial sequencing of the full human genome took over 10 years and cost more than £2bn (€2.4bn; $3bn), an individual’s genome can now be sequenced in around a day at a cost of less than £700 456…”

Section: Transforming Genomics In Ukmentioning

confidence: 99%

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

Turnbull

Scott

Thomas

et al. 2018

BMJ

350

292

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Section: Transforming Genomics In Ukmentioning

confidence: 99%

The 100 000 Genomes Project: bringing whole genome sequencing to the NHS

Turnbull

Scott

Thomas

et al. 2018

BMJ

350

292

View full text Add to dashboard Cite

“…11 The strong push for a more wide-spread use of whole-genome sequencing makes practical sense, as both the rate of increase in the speed of genome sequencing and the rate of decline in the genome sequencing cost in recent years easily surpasses the Moore’s law—a projection in the computer industry describing the doubling of growth (e.g., number of transistors in an integrated circuit) every 2 years. 12 However, does DNA alone predict disease?…”

Section: Roles Of Hipscs In Precision Medicinementioning

confidence: 99%

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine

2016

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The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized much of the efforts within the past decade to more fully realize the potential of human embryonic stem cells (hESCs). Adding to the possibility of generating unlimited supplies of any cell types of interest, the hiPSC technology now enables the derivation of cells with patient-specific phenotypes. With the Precision Medicine Initiative, it is clear that the hiPSC technology will play a vital role in the advancement of cardiovascular research and medicine. This review summarizes the tremendous and continuing progress that has been made in the field of hiPSC technology, with particular emphasis on cardiovascular disease modeling and drug development. Wherever appropriate, the growing roles of hiPSC technology in the practice of precision medicine will be specifically discussed.

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“…The cost of first decoding a human genome amounted to approximately US$3 billion [25]; even as of 2001, the cost of WGS was estimated at about US$100 million [26]. Meanwhile, technology firms yield at performing a WGS for less than US$1000 per genome [27][28][29]. However, the literature lacks relevant cost studies [30].…”

Section: Introductionmentioning

confidence: 99%