Technology Innovations in Dietary Intake and Physical Activity Assessment: Challenges and Recommendations for Future Directions

Klurfeld, David M.; Hekler, Eric B.; Nebeker, Camille; Patrick, Kevin; Khoo, Chor San

doi:10.1016/j.amepre.2018.06.013

Cited by 6 publications

(1 citation statement)

References 21 publications

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“…While rodent models are cost-effective, it is unclear how well outcomes from those models translate to humans. However, animal models are necessary for long-term randomized studies of diets that may have deleterious health consequences [55][56][57]. The use of a pig model allows us to bridge the gap between experimental rodent studies and observational human studies and take advantage of a longer developmental scale as compared to rodents [58][59][60].…”

Section: Discussionmentioning

confidence: 99%

High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) is a serious metabolic condition affecting millions of people worldwide. A “Western-style diet” has been shown to induce pediatric NAFLD with the potential disruption of skeletal muscle composition and metabolism. To determine the in vivo effect of a “Western-style diet” on pediatric skeletal muscle fiber type and fuel utilization, 28 juvenile Iberian pigs were fed either a control diet (CON) or a high-fructose, high-fat diet (HFF), with or without probiotic supplementation, for 10 weeks. The HFF diets increased the total triacylglycerol content of muscle tissue but decreased intramyocellular lipid (IMCL) content and the number of type I (slow oxidative) muscle fibers. HFF diets induced autophagy as assessed by LC3I and LC3II, and inflammation, as assessed by IL-1α. No differences in body composition were observed, and there was no change in insulin sensitivity, but HFF diets increased several plasma acylcarnitines and decreased expression of lipid oxidation regulators PGC1α and CPT1, suggesting disruption of skeletal muscle metabolism. Our results show that an HFF diet fed to juvenile Iberian pigs produces a less oxidative skeletal muscle phenotype, similar to a detraining effect, and reduces the capacity to use lipid as fuel, even in the absence of insulin resistance and obesity.

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