“…Orbitofrontal and medial prefrontal cortex, when affected, overstimulate the HPA, which has a detrimental influence on the hippocampus—a structure crucial for memory [ 7 , 46 , 65 ]. Nonetheless, it is worth noting that the bidirectional relationship between loneliness and dementia can be possibly explained by their shared additional biological or environmental risk or preventive factors [ 14 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 49 , 50 , 51 , 52 , 53 , 54 ].…”