Technology Assessment and the University

Cobb, John C.

doi:10.1126/science.181.4099.495.c

Cited by 1 publication

(1 citation statement)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[11] In addition, pharmacological studies of crude extracts from this plant have reported neuroprotective and antioxidant activities (neurodegenerative diseases), [6] anti-inflammatory, [2,12] antioxidant, [2] cytotoxicity [13] and anti-tumour. [14] In addition, previous phytochemical investigationsofthis plant revealed the existence of lignans, [15] terpenoidsand steroids [16] and sesquiterpene lactone. [17] The present study was carried out to investigate the composition of polyphenol fraction using HPLC-DAD and HPLC-ESI-MS, as well as the anti-inflammatory (in vitro and in silico), antibacterial and anti-Alzheimer (in silico) activities of therich extracts.…”

Section: Introductionmentioning

confidence: 99%

HPLC/ESI‐MS Characterization of Phenolic Compounds from Cnicus benedictus L. Roots: A Study of Antioxidant, Antibacterial, Anti‐Inflammatory, and Anti‐Alzheimer's Activity

Rezig,

Benkaci‐Ali,

Fauconnier

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

The phenolic composition of Cnicus benedictus roots from four Algerian regions was investigated. Extractions were performed in both hydro‐methanolic (30 : 70, v/v) and hydro‐ethanolic (30 : 70, v/v) solvents. Their efficiency was determined in terms of the qualitative and quantitative composition in phenolic compounds by HPLC‐LC/MS of the different extracts isolated from C. Benedictus roots. Cnicus benedictus roots extract have been characterized by high content of phenolic compounds, where the trans chalcone, 2,3‐dihydro flavone, 3‐hydroxy flavone and cinnamic acid constitute the major components, in addition to fourteen minor acidic compounds and flavonoids as rutin. The hydro‐methanolic extract was the richest in phenolic compounds yield from C benedictus. On the other hand, hydro methanolic (30 : 70, v/v) and hydro ethanolic (30 : 70, v/v) extracts exhibited a high anti‐inflammatory activity by in vitro 5‐lipoxygenase inhibitory activity (IC50: 6.05±94.16 μg/mL) as well as by in silico docking according two methods. Likewise, anti‐Alzheimer activity of extracts was confirmed by this last technique taking into account the major compounds identified. Antibacterial tests revealed interesting results compared to amoxicillin for the different regions studied with a high content in trans chalcone and 3‐hydroxy Flavone.

show abstract