Technologies for the control of fat and lean deposition in livestock

Sillence, M. N.

doi:10.1016/j.tvjl.2003.10.020

Cited by 124 publications

(102 citation statements)

References 149 publications

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“…Among the benefits to the producer of enhanced feed conversion efficiency include lower production costs, higher product yields, less nitrogenous-waste excretion into the environment, and decreased grazing pressure. Achievement of increased feed conversion efficiency can be attained through the use of hormonal growth promoters, transgenic animals, nutritional strategies, choice of terminal sire breed, and marketing lambs at appropriate slaughter weights (reviewed in [3,52]). However, the banning of hormonal growth promoters by the European Union, the problems with gene expression in transgenic animals, and the limited advance of nutritional studies in sheep have restricted the incorporation of these strategies into production schemes.…”

Section: Introductionmentioning

confidence: 99%

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

et al. 2005

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-Genetic strategies to improve the profitability of sheep operations have generally focused on traits for reproduction. However, natural mutations exist in sheep that affect muscle growth and development, and the exploitation of these mutations in breeding strategies has the potential to significantly improve lamb-meat quality. The best-documented mutation for muscle development in sheep is callipyge (CLPG), which causes a postnatal muscle hypertrophy that is localized to the pelvic limbs and loin. Enhanced skeletal muscle growth is also observed in animals with the Carwell (or rib-eye muscling) mutation, and a double-muscling phenotype has been documented for animals of the Texel sheep breed. However, the actual mutations responsible for these muscular hypertrophy phenotypes in sheep have yet to be identified, and further characterization of the genetic basis for these phenotypes will provide insight into the biological control of muscle growth and body composition.sheep / muscle / hypertrophy / callipyge / mutation

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Section: Introductionmentioning

confidence: 99%

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

et al. 2005

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“…In livestock industry, certain feed additives are commonly used to improve the efficiency of feed utilization and to enhance the meat leanness (1,2). Prominent among these feed additives are ractopamine (3), clenbuterol (4) and salbutamol (5).…”

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confidence: 99%

Sulfation of ractopamine and salbutamol by the human cytosolic sulfotransferases

Kurogi

Davidson

et al. 2012

Journal of Biochemistry

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-Cheh Liu *These two authors contributed equally to this study.Feed additives such as ractopamine and salbutamol are pharmacologically active compounds, acting primarily as b-adrenergic agonists. This study was designed to investigate whether the sulfation of ractopamine and salbutamol may occur under the metabolic conditions and to identify the human cytosolic sulfotransferases (SULTs) that are capable of sulfating two major feed additive compounds, ractopamine and salbutamol. A metabolic labelling study showed the generation and release of [ 35 S]sulfated ractopamine and salbutamol by HepG2 human hepatoma cells labelled with [ 35 S]sulfate in the presence of these two compounds. A systematic analysis using 11 purified human SULTs revealed SULT1A3 as the major SULT responsible for the sulfation of ractopamine and salbutamol. The pH dependence and kinetic parameters were analyzed. Moreover, the inhibitory effects of ractopamine and salbutamol on SULT1A3-mediated dopamine sulfation were investigated. Cytosol or S9 fractions of human lung, liver, kidney and small intestine were examined to verify the presence of ractopamine-/ salbutamol-sulfating activity in vivo. Of the four human organs, the small intestine displayed the highest activity towards both compounds. Collectively, these results imply that the sulfation mediated by SULT1A3 may play an important role in the metabolism and detoxification of ractopamine and salbutamol.

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“…that halothane carriers grew faster and had a higher portion of muscle tissue in carcass (Monin, 1999;Miller et . Schinckel et al (2001) and Sillence (2004) reported that the effect of genotype on the growth of muscle tissue was reduced as the finishing fattening phase approached. The present study opposes the results of Whang et al (2003), who stated that an intensified feeding regime led to intensive development of muscle tissue in the particular growth phases.…”

Section: Resultsmentioning

confidence: 99%

“…This is contrary to the research of Holck et al (1997), who pointed out a significant effect of environmental factors, mostly of feeding. On the other hand, Sillence (2004) emphasized genotype as a factor that significantly affects the growth of muscle tissue in hams as well as in the whole carcass in the starting growth phase. Monin (1999), Miller et al (2000) and Rosner et al (2003) also reported a higher portion of muscle tissue in pigs of Nn genotype when fed intensively.…”

Section: Resultsmentioning

confidence: 99%

Lean and fat development in the whole body and hams of hybrid pigs studied by magnetic resonance tomography

Margeta¹,

Kralik²,

Kušec³

et al. 2007

CZECH J ANIM SCI

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ABSTRACT:The aim of this study was to determine the influence of MHS-genotype and feeding regime on the growth and development of muscle and fatty tissue in the whole body as well as in hams of hybrid pigs. The experiment was carried out on 72 barrows that were divided into 4 groups regarding the MHS-genotype (NN and Nn) and feeding regime (standard and intensive). Data necessary to determine the volume of examined tissues were obtained by means of magnetic resonance tomography. During the fattening period there were no statistically significant differences between pig groups with respect to total lean content of the body although the feeding regime effect in the finishing fattening phase was on the margin of statistical significance (P = 0.057). Differences between investigated groups with respect to the lean content in hams were not significant either. Results of this research lead to a conclusion that different feeding regimes and MHS genetic status of pigs do not have a significant influence on the growth of muscle and fatty tissue in hams.

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Technologies for the control of fat and lean deposition in livestock

Cited by 124 publications

References 149 publications

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

The callipyge mutation and other genes that affect muscle hypertrophy in sheep

Sulfation of ractopamine and salbutamol by the human cytosolic sulfotransferases

Lean and fat development in the whole body and hams of hybrid pigs studied by magnetic resonance tomography

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