This research combines technical, environmental, and economic aspects regarding the utilization of Bege Bahia marble waste (BB) in clinker production. Three different eco-friendly clinkers were produced, investigated, and compared with one that is commercially available. BB was used to replace 49.2%, 77%, and 80.3% of the limestone by total amount of clinker. Two clinkers were selected to produce cement pastes, and their impact on compressive strength at 28 days was examined. The results suggest that substituting limestone with BB does not adversely affect the compressive strength of cement paste. Moreover, employing 77% or 80.3% BB in clinker production does not significantly influence the alite and belite contents but slightly increases the tricalcium aluminate and ferrite phases while reducing the periclase content. A life cycle analysis was conducted to assess the effects of replacing limestone with marble waste. The results revealed a substantial decrease in abiotic depletion, leading to conservation of substantial natural resources. Consequently, the utilization of BB in clinker production makes a significant contribution to environmental preservation while providing an effective alternative to limestone. In addition, the resulting clinkers serve as useful repositories, providing a permanent and sustainable destination for waste that is currently deposited in landfills. Finally, the economic viability was also examined under various scenarios based on the distance between marble and cement plants. The results highlight the transport distance of marble waste as the primary determinant of economic feasibility in utilizing this residue as a limestone replacement.