Technological strategies to improve photostability of a sunscreen agent

Perugini, Paola; Vettor, Manuela Teresa; Tursilli, Rosanna; Scalia, Santo; Modena, Tiziana; Pavanetto, F; Conti, Bice

doi:10.1111/j.1467-2494.2006.00307_5.x

Cited by 3 publications

(6 citation statements)

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“…The behavior of sunscreen final products are also not predictable from the photostability of its individual filters, so it is important to evaluate the final formulation [9,10]. In fact, sunscreen vehicles can often impact on the sun protection factor (SPF) [11].…”

Section: Introductionmentioning

confidence: 99%

Stability Study of Sunscreens with Free and Encapsulated UV Filters Contained in Plastic Packaging

et al. 2017

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Sunscreens play a fundamental role in skin cancer prevention and in protection against photo-aging. UV filters are often photo-unstable, especially in relation to their vehicles and, being lipophilic substances, they are able to interact with plastic packaging. Finally, UV filter stability can be significantly affected by the routine use of the product at high temperatures. This work aims to study the stability of sunscreen formulations in polyethylene packaging. Butyl methoxydibenzoylmethane and octocrylene, both in a free form and as encapsulated filters were chosen as UV filters. Stability evaluations were performed both in the packaging and on the formulations. Moreover, a further two non-destructive techniques, near-infrared (NIR) spectroscopy and a multiple light scattering technique, were also used to evaluate the stability of the formulation. Results demonstrated clearly that all of the pack underwent significant changes in its elastic/plastic behavior and in external color after solar irradiation. From the evaluation of the extractable profile of untreated and treated packaging material an absorption of 2-phenoxyethanol and octocrylene were shown. In conclusion, the results highlighted clearly that a reduction of the UV filter in the formulation packed in high-density polyethylene/low-density polyethylene (HDPE/LDPE) material can occur over time, reducing the protective effect of the product when applied to the skin.

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Section: Introductionmentioning

confidence: 99%

Stability Study of Sunscreens with Free and Encapsulated UV Filters Contained in Plastic Packaging

et al. 2017

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“…Since the photostability of a final sunscreen product is difficult to predict from its individual filter, it is proposed in the relevant literature to determine the photostability only of the final product [25,28]. In view of the above, in this study two commercially available reference SPF standards and two oil-in-water sunscreen products containing either physical and chemical UV filters or just chemical filters were chosen for photostability testing.…”

Section: Discussionmentioning

confidence: 99%

The Influence of Short-Wave and Long-Wave Radiation Spectrum on the Photostability of Sunscreens

Garbe

Kockott²,

Werner

et al. 2020

Skin Pharmacol Physiol

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Background: Sunscreen products aim to help protect the skin against UV radiation and consequently reduce the risk of early skin ageing and skin cancer. However, it is well known that some sunscreen ingredients are not photostable, but this usually refers to irradiation with UV light. Moreover, it has to be mentioned that a relative cumulative erythema effectiveness compliant light source is used for the in vivo sun protection factor (SPF) testing. Here, UV simulators equipped with a xenon arc lamp use filters such as WG320 and UG11 (thickness 1 mm) to minimize infrared (IR) radiation and wavelength below 300 nm. However, under practical conditions, the sunscreen product is not only exposed to UVA/B light, but also to visible light (VIS) and IR light. In fact, the spectrum of solar radiation is composed of approximately 7% UV, 39% VIS and 54% IR. Aims: To investigate the influence of short-wave and long-wave radiation on the photostability of sunscreens. Methods: Irradiation was performed

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“…Photodegradation studies were carried out on formulation containing free OMC or OMC-loaded nanoparticles. A portion of test sample (75-80 mg) was transferred to the bottom of a beaker and irradiated for 2 h with a solar simulator (Suntest CPS+) equipped with a Xenon lamp, an optical filter to cut off wavelength shorter than 290 nm and an IR-block filter to avoid thermal effect [19,23].…”

Section: Photodegradation Studiesmentioning

confidence: 99%

“…Octyl-p-methoxy-cis-cinnamate, the only degradation compound resulting from the irradiation of OMC [19], absorbs the UV radiation less efficiently than the original trans-isomer and hence this isomerization lowers the UV protective capacity [14].…”

Section: Photodegradation Studiesmentioning

confidence: 99%

“…Perugini et al by evaluating the photostability of the OMC in different formulation types (emulsion-gel, gel and emulsion) highlighted that the encapsulation of OMC into nanoparticles made of poly-d,l-lactide-co-glicolide results in a reduction of the photodegradation from 52.3 to 35.3% [19,20]. A comparable result was obtained by encapsulating the sunscreen agent in poly--caprolactone nanoparticles [21].…”

Section: Introductionmentioning

confidence: 99%

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Poly(D,L‐lactide) nanoencapsulation to reduce photoinactivation of a sunscreen agent

Vettor

Perugini

Scalia

et al. 2008

Intern J of Cosmetic Sci

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The use of sunscreens is the 'gold standard' for protecting the skin from ultraviolet light. Octyl methoxycinnamate (OMC) is one of the most widely used UVB filter but it can act as a sensitizer or photoallergen. When exposed to sunlight, OMC can change from the primary trans-form to cis-form and the isomerization, not reversible, conducts to a reduction of the UVB filtering efficiency because the trans-form has a higher extinction coefficient. Photostability is the most important characteristic of effective sunscreens and it can be influenced by formulation ingredients and by applying technological strategies. In this work, photostability experiments, performed on emulsion-gels containing different percentages of OMC free or loaded in poly(D,L-lactide) nanoparticles, were carried out. The presence of a polymeric envelop may act to protect the active ingredient. In this study, the influence of poly(D,L-lactide) matrices on the photochemical stability of the sunscreen agent was investigated. As highlighted in this study, free OMC in different formulations has different photoisomerization degree. Moreover, a dissimilar behaviour was observed by studying different sunscreen concentrations in the same cosmetic formulation. Photostability results show a significant reduction in photoisomerization degree for formulations containing sunscreen loaded in nanoparticles, highlighting that the encapsulation is a suitable strategy to improve OMC photostability. Moreover, sun protection factor (SPF) results show that the UVB filter protective power is also maintained after encapsulation.

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Technological strategies to improve photostability of a sunscreen agent

Cited by 3 publications

References 0 publications

Stability Study of Sunscreens with Free and Encapsulated UV Filters Contained in Plastic Packaging

Stability Study of Sunscreens with Free and Encapsulated UV Filters Contained in Plastic Packaging

The Influence of Short-Wave and Long-Wave Radiation Spectrum on the Photostability of Sunscreens

Poly(D,L‐lactide) nanoencapsulation to reduce photoinactivation of a sunscreen agent

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