Technological solutions for encapsulation

Trojanowska, Anna; Nogalska, Adrianna; Valls, Ricard Garcia; Giamberini, Marta; Tylkowski, Bartosz

doi:10.1515/nano.0077.00002

Cited by 3 publications

(15 citation statements)

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“…[ 21 ] Coacervation describes a process in which the precipitation of polymer aggregates (coacervates) on the surface of minute core materials is triggered by external stimuli, including temperature, pH, antisolvent, salt, etc. [ 22 ] Likewise, the self‐assembly process in our case is a typical example of coacervation. As shown in Figure a, the preparation of the nanoparticles begins with the dispersion of AIEgens and TA/Fe 3+ complexes in THF/water mixtures.…”

Section: Resultsmentioning

confidence: 92%

One‐Pot Synthesis of Customized Metal–Phenolic‐Network‐Coated AIE Dots for In Vivo Bioimaging

Peng

Yang

et al. 2022

Advanced Science

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The integration of aggregation-induced emission luminogens (AIEgens) and inorganic constituents to generate multifunctional nanocomposites has attracted much attention because it couples the bright aggregate-state fluorescence of AIEgens with the diverse imaging modalities of inorganic constituents. Herein, a facile and universal strategy to prepare metal-phenolic-network (MPN)-coated AIE dots in a high encapsulation efficiency is reported. Through precise control on the nucleation of AIEgens and deposition of MPNs in tetrahydrofuran/water mixtures, termed as coacervation, core-shell MPN-coated AIE dots with bright emission are assembled in a one-pot fashion. The optical properties of MPN-coated AIE dots can be readily tuned by varying the incorporated AIEgens. Different metal ions, such as Fe 3+ , Ti 4+ , Cu 2+ , Ni 2+ , can be introduced to the nanoparticles. The MPN-coated AIE dots with a red-emissive AIEgen core are successfully used to perform magnetic resonance/fluorescence dual-modality imaging in a tumor-bearing mouse model and blood flow visualization in a zebrafish larva. It is believed that the present study provides a tailor-made nanoplatform to meet the individual needs of in vivo bioimaging.

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Section: Resultsmentioning

confidence: 92%

One‐Pot Synthesis of Customized Metal–Phenolic‐Network‐Coated AIE Dots for In Vivo Bioimaging

Peng

Yang

et al. 2022

Advanced Science

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“…In 1953, Green and Schleicher developed the first encapsulation technology of coacervation, where coacervate forces were used to encapsulate trichlorodiphenyl inside microscopic gelatin capsules. 28 Phase separation or coacervation commonly features turbid appearance, the formation of droplets and separation of liquid layers. 31 Coacervation is described by two methods, namely, simple and complex coacervation.…”

Section: Phase Separation Methodsmentioning

confidence: 99%

“…37 This technique produces broad permeable coefficient spectrum capsules based on the desired application. 28 Substrate types such as mica, quartz, glass and silica water are commonly used for the layer-bylayer technique. The assembly of multiple layers requires suitable substrates that can hold and support the organisation of the materials.…”

Section: Phase Separation Methodsmentioning

confidence: 99%

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An overview of the science and art of encapsulated pigments: Preparation, performance and application

Tawiah

Asinyo

Frimpong

et al. 2022

Coloration Technology

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Pigments are classified as organic or inorganic based on their chemical composition. 1,2 Typically, organic pigments comprise compounds of carbon elements that participate in covalent bonding, while inorganic pigments consist primarily of ground minerals such as metals, metallic salts (except barium salts of dyes) and metalloid salts, which do not contain carbon bonds. 3 Although some organic pigments may contain inorganic elements as stabilisers, organic pigments are defined primarily based on their congugated carbon bonds (except carbon black). 2 To improve the chemical, thermal, freeze-thaw and dispersion stability of organic pigments upon application, these classes of pigments have been the subject of extensive research over the years due to their obvious advantages. [4][5][6] Typically, the colour strength and optical properties of coated/printed substrates depend largely on the quality of the pigmented ink/paste and the nature of the substrate. The quality of the pigmented ink/paste then rests on the quality of the dispersion system (ie, the degree of the dispersion and its stability). 5,7 Dispersion stability is very important from the point of view of surface coatings and printing systems, especially for encapsulated inks that

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“…Wurster fluidised bed coating is routinely used in pharmaceutical processes. It offers an industrial-scalable method for producing drug-loaded discrete MPs surrounded by polymer film-coatings providing sustained drug release (25). The size of the MPs is crucial for the creation of effective and stable liquid dosage forms, influencing dosage uniformity (26), sedimentation rate (27), as well as oral sensations such as grittiness (28) and patients’ adherence to the medication (29).…”

Section: Introductionmentioning

confidence: 99%

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

et al. 2019

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Suspension of microparticles in an easy-to-swallow liquid is one approach to develop sustained-release formulations for children and patients with swallowing difficulties. However, to date production of sustained-release microparticles at the industrial scale has proven to be challenging. The aim of this investigation was to develop an innovative concept in coating sustained-release microparticles using industrial scalable Wurster fluidised bed to produce oral liquid suspensions. Microcrystalline cellulose cores (particle size <150 μm) were coated with Eudragit® NM 30 D and Eudragit® RS/RL 30 D aqueous dispersions using a fluidised bed coater. A novel approach of periodic addition of a small quantity (0.1% w/w) of dry powder glidant, magnesium stearate, to the coating chamber via an external port was applied throughout the coating process. This method significantly increased coating production yield from less than 50% to up to 99% compared to conventional coating process without the dry powder glidant. Powder rheology tests showed that dry powder glidants increased the tapped density and decreased the cohesive index of coated microparticles. Reproducible microencapsulation of a highly water-soluble drug, metoprolol succinate, was achieved, yielding coated microparticles less than 200 μm in size with 20-h sustained drug release, suitable for use in liquid suspensions. The robust, scalable technology presented in this study offers an important solution to the long-standing challenges of formulating sustained-release dosage forms suitable for children and older people with swallowing difficulties.

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Technological solutions for encapsulation

Cited by 3 publications

References 0 publications

One‐Pot Synthesis of Customized Metal–Phenolic‐Network‐Coated AIE Dots for In Vivo Bioimaging

One‐Pot Synthesis of Customized Metal–Phenolic‐Network‐Coated AIE Dots for In Vivo Bioimaging

An overview of the science and art of encapsulated pigments: Preparation, performance and application

Wurster Fluidised Bed Coating of Microparticles: Towards Scalable Production of Oral Sustained-Release Liquid Medicines for Patients with Swallowing Difficulties

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