Technological integration and hyperconnectivity: Tools for promoting extreme human lifespans

Kyriazis, Marios

doi:10.1002/cplx.21626

Cited by 7 publications

(8 citation statements)

References 43 publications

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“…This is also sometimes known as dual inheritance theory [50] . An extension of this concept describes the effects from our increasingly technological culture upon our own biology [51] , and at the same time, it describes how humanity can influence the further evolution of the environment itself [52] . In this way it may be possible to appreciate the complex and mutually influencing interactions of each patient with the environment, and begin to form a view which is at odds with the simplistic reductionist view that "one drug fits all" paradigm [53] .…”

Section: Social Genomicsmentioning

confidence: 99%

The failure of “engineered rejuvenation”: laboratory genomics do not translate into precision anti-aging therapies

Kyriazis¹

2018

JTGG

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There is a general failure of reductionist and mechanistic approaches to rejuvenation biomedical technologies which aim at providing treatments against aging (defined as "time-dependent dysfunction"). Importantly, it is becoming increasingly recognised that genomic research findings in animals may not adequately be translated into effective human anti-aging therapies. There exist translational impediments, which although individually formidable, can theoretically be overcome. However, the combined effects of these obstacles render this reductionist avenue of quest unattainable, at least for the foreseeable future. Some of the clinical problems of physical and genomic-based therapies against aging include side effects, interactions, inter-subject variability, compliance, patient self-reporting of data, motivation, administrative issues, infrastructure, etc. A systematic review spanning over the past 5 years, describes these problems and identifies novel approaches. New and emerging disciplines and concepts such as molecular pathological epidemiology, social genomics and other "systems-thinking" methods provide a more comprehensive view of the entire subject of aging, and study its indivisible bonds with the environment, society and culture. The so-called "fountain of youth" cannot be found in a physical item.

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Section: Social Genomicsmentioning

confidence: 99%

The failure of “engineered rejuvenation”: laboratory genomics do not translate into precision anti-aging therapies

Kyriazis¹

2018

JTGG

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“…This, translated into clinical terms, may mean that the soma (as defined in Box 1) experiences continual repair and lives without any significant age-related chronic degeneration. I have suggested [33] that some of these evolutionary pressures could be dependent upon how well one makes themselves 'indispensable' within the global techno-cultural environment, through intense (but hormetic) sharing of information, which has an impact on somatic neurons which, then, diminish the evolutionary importance of germ line cells (Figure 3). response to heat or oxidation.…”

Section: The 'Indispensable Soma Hypothesis'mentioning

confidence: 99%

Environmental challenges may impact on somatic repair

Kyriazis¹

2015

Preprint

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During the process of ageing there is canalisation of repair resources which tend to flow from the soma towards the germ line. In the early periods of phylogenetic development there was a time when repair of germ line cells became more efficient compared to the repair of somatic cells. The level of somatic repair became just enough to ensure that the organism reached sexual maturity. It was the biological equivalent of the mathematical bifurcation, when the pathway developed preferentially towards the germ line attractor. We are now looking for evidence that this could be changing, that we may be witnessing a phase transition from effective germ line repair to an effective somatic repair. Here I consider mechanisms of fidelity-preservation which may be present in the germ line, and examine the possibility that these may be made to operate upon somatic cells instead. Mechanisms which safeguard the reliability of germ line repair and ensuring robustness/resilience in the germ line may also (or instead) be applicable upon somatic material (cells and molecules, factors) and ensure a continually effective repair of this somatic material. Thus the ability to continually repair and maintain somatic organic material within biological systems is not lost. Continual challenges from the environment ensure that the flow of information remains active and it persistently stimulates the ability to repair the soma. Apart from germ line cells, some unicellular organisms such as bacteria maintain their ability for ongoing repairs, a fact that indicates that, in principle, senescence is not unavoidable.

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“…A partir del estado del arte y de las inquietudes emergentes sobre el efecto de las fluctuaciones imaginarias en la cultura y el sujeto, se contempla al fenómeno de las selfies como la representación de los hábitos y necesidades de la personalidad en un ecosistema virtual. Se permite llamar "ecosistema" a la red, en el sentido de la biología, ya que toda especie incluida en un entorno debe adaptarse para la expresión de sus posibilidades (Kyriazis, 2015). En las redes sociales el peligro es la extinción y un signo de adaptación es el número de likes, seguidores y reforzadores simbólicos (Marwick, 2015).…”

Section: Introductionunclassified

Estudio sobre el fenómeno de las selfies en las redes sociales y sus implicaciones para el marketing

Barajas-Portas¹,

González²,

Mercado³

et al. 2017

TAJ

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La presente investigación analiza las descripciones de las representaciones que las “selfies” tienen para losconsumidores jóvenes. Aportamos explicaciones de fondo de las selfies, la forma en que las perciben los consumidores y lo que representan en su vida. Los individuos generan y comparten este tipo de imágenes diariamente, por lo que es necesario entender su rol en la vida de los consumidores. La presente investigación se basa en el análisis de metáforas, debido a que estas encuadran las formas en que los individuos perciben y actúan en el mundo. Sobre los datos obtenidos de 32 consumidores jóvenes, y utilizando la técnica proyectiva de inducción de metáforas de Zaltman (ZMET), se capturan los sentimientos y emociones profundas de los entrevistados con respecto a las selfies. Los resultados ponen de relieve la importancia de las metáforas de 1) conexión, 2) emociones, 3) momentos especiales y 4) tecnología. Los principales hallazgos sustentan la importancia que este fenómeno tiene sobre las implicaciones de la gestión del marketing.

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Technological integration and hyperconnectivity: Tools for promoting extreme human lifespans

Cited by 7 publications

References 43 publications

The failure of “engineered rejuvenation”: laboratory genomics do not translate into precision anti-aging therapies

The failure of “engineered rejuvenation”: laboratory genomics do not translate into precision anti-aging therapies

Environmental challenges may impact on somatic repair

Estudio sobre el fenómeno de las selfies en las redes sociales y sus implicaciones para el marketing

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