Techno-economic evaluation and life cycle assessment of a biorefinery using winery waste streams for the production of succinic acid and value-added co-products

Ioannidou, Sofia Maria; Filippi, Katiana; Kookos, Ioannis K.; Koutinas, Apostolis; Ladakis, Dimitrios

doi:10.1016/j.biortech.2021.126295

Cited by 34 publications

(12 citation statements)

References 34 publications

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“…For the laboratory fed-batch scenario, the MPSP, GWP100, and FEC of our biorefinery were the lowest reported values thus far for a biorefinery producing SA. Furthermore, for the pilot batch scenario, the biorefinery's MPSP of $1.37/kg [$1.23-1.54/kg; 5th-95th percentiles, hereafter in brackets] was consistently below the reported market price range of $2.53-2.89/kg 30 (adjusted to 2016$) and near the low end of bio-based SA MPSP values ranging from $1.08-3.63/kg reported in the literature 42,43,44,45,46,47,48,49,50 (Fig. 4A).…”

Section: Discussionmentioning

confidence: 76%

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

Tran

Mishra

Bhagwat

et al. 2023

Preprint

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As one of the top value-added chemicals, succinic acid has been the focus of numerous metabolic engineering campaigns since the 1990s. However, microbial production of succinic acid at an industrially relevant scale has been hindered by high downstream processing costs arising from neutral pH fermentation. Here we describe the metabolic engineering of Issatchenkia orientalis, a non-conventional yeast with superior tolerance to highly acidic conditions, for cost-effective succinic acid production. Through deletion of byproduct pathways, transport engineering, and expanding the substrate scope, the resulting strains could produce succinic acid at the highest titers in sugar-based media at low pH (pH 3) in fed-batch fermentations using bench-top reactors, i.e. 109.5 g/L in minimal medium and 104.6 g/L in sugarcane juice medium. We further performed batch fermentation in a pilot-scale fermenter with a scaling factor of 300-fold, achieving 63.1 g/L of succinic acid using sugarcane juice medium. A downstream processing comprising of two-stage vacuum distillation and crystallization enabled direct recovery of succinic acid, without further acidification of fermentation broth, with an overall yield of 64.0%. Finally, we simulated an end-to-end low-pH succinic acid production pipeline, and techno-economic analysis and life cycle assessment indicate our process is financially viable and can reduce life cycle greenhouse gas emissions by 34-90% relative to fossil-based production processes. We expect I. orientalis can serve as a general industrial platform for the production of a wide variety of organic acids.

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Section: Discussionmentioning

confidence: 76%

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

Tran

Mishra

Bhagwat

et al. 2023

Preprint

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“…It depends on many factors, including the availability of low-cost biomass feedstock, economic competitiveness with petrochemical routes, and environmental benefits/impacts associated with these processes. In this direction, extensive studies have been reported on techno-economic and life cycle analysis for fermentative production of SA from various biomasses and wastes (Table 9) [186][187][188][189][190][191]. SA production costs or selling prices vary depending on the type of feedstock and plant capacity.…”

Section: Sustainability Assessmentmentioning

confidence: 99%

Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry

Kumar,

Maity

et al. 2024

Biotechnol Biofuels

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Succinic acid (SA) is one of the top platform chemicals with huge applications in diverse sectors. The presence of two carboxylic acid groups on the terminal carbon atoms makes SA a highly functional molecule that can be derivatized into a wide range of products. The biological route for SA production is a cleaner, greener, and promising technological option with huge potential to sequester the potent greenhouse gas, carbon dioxide. The recycling of renewable carbon of biomass (an indirect form of CO2), along with fixing CO2 in the form of SA, offers a carbon-negative SA manufacturing route to reduce atmospheric CO2 load. These attractive attributes compel a paradigm shift from fossil-based to microbial SA manufacturing, as evidenced by several commercial-scale bio-SA production in the last decade. The current review article scrutinizes the existing knowledge and covers SA production by the most efficient SA producers, including several bacteria and yeast strains. The review starts with the biochemistry of the major pathways accumulating SA as an end product. It discusses the SA production from a variety of pure and crude renewable sources by native as well as engineered strains with details of pathway/metabolic, evolutionary, and process engineering approaches for enhancing TYP (titer, yield, and productivity) metrics. The review is then extended to recent progress on separation technologies to recover SA from fermentation broth. Thereafter, SA derivatization opportunities via chemo-catalysis are discussed for various high-value products, which are only a few steps away. The last two sections are devoted to the current scenario of industrial production of bio-SA and associated challenges, along with the author's perspective.

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“…The high organic content of these wastes not only implies ecological concerns if discharged without further treatment but also provides a reservoir of carbon sources for chemicals and energy production. In comparison to the first-generation bioethanol industry, their integration into a second-generation biorefinery model would reduce the environmental impact of the wine industry through cost-effective waste valorization (Ioannidou et al, 2022;Moonsamy et al, 2022). Furthermore, multi-product biorefineries are being promoted (Baptista et al, 2021) rather than traditional biorefineries that focus on the production of a single product (Baptista et al, 2021;del Río et al, 2021).…”

Section: Integrated Biorefinery From Wine Wastementioning

confidence: 99%

Multi-feedstock biorefinery concept: Valorization of winery wastes by engineered yeast

Baptista

Romaní

Cunha

et al. 2023

Journal of Environmental Management

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Techno-economic evaluation and life cycle assessment of a biorefinery using winery waste streams for the production of succinic acid and value-added co-products

Cited by 34 publications

References 34 publications

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

An End-to-end Pipeline for Succinic Acid Production at an Industrially Relevant Scale usingIssatchenkia orientalis

Recent advances in bio-based production of top platform chemical, succinic acid: an alternative to conventional chemistry

Multi-feedstock biorefinery concept: Valorization of winery wastes by engineered yeast

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