Nuclear power is the most reliable source of clean energy and plays a crucial role in decarbonization efforts and national energy security. Achievement of Net-Zero targets depends on the deployment of new Nuclear Power Plants (NPPs) -both advanced reactors and large-scale Light-Water Reactors (LWRs)as well as continued operations at existing LWR plants. The Light-Water Reactor Sustainability (LWRS) Program seeks to extend the lifetime of existing LWR NPPs and improve their economic performance through research into plant modernization, Flexible Plant Operation and Generation (FPOG) (including techno-economic evaluations of hybrid generation options such as energy storage, coupling with industry, etc), risk-informed systems analysis, materials research, and physical security.