Techniques of intrauterine fetal transfusion for women with red-cell isoimmunisation for improving health outcomes

Diagnosis and treatment of severe hemolytic disease of the fetus and newborn: a 10‐year nationwide retrospective study

“…The same tendency was also seen in our cohort, with over 10% risk of severe bradycardia observed in transfusions performed after 34 weeks of gestation. As long as there is no clear evidence in favor of any of the techniques used in IUTs, the choice of technique remains with the operator, but these technical aspects should be considered carefully when transfusing near‐term fetuses . Nevertheless, the high cesarean rate in our cohort may not only be procedure‐related but possibly also may reflect a lower threshold for cesarean delivery and for choosing extrauterine treatment in centers with a small number of cases per year.…”

Noninvasive Single-Exon Fetal RHD Determination in a Routine Screening Program in Early Pregnancy

“…To access the fetal circulation the umbilical vein is punctured. A recent Cochrane review stated that there are too few randomized controlled trials to determine the optimal procedural technique to use when performing IUT 76 . Today, the umbilical vein either at its insertion into the placenta or in the intrahepatic portion in the fetal abdomen is used depending on fetal and placental position.…”

Direct Fetal Intravenous Immunoglobulin Infusion as an Adjunct to Intrauterine Fetal Blood Transfusion in Rhesus-Allommunized Pregnancies: A Pilot Study

“…There is now convincing evidence of the benefit of neonatal IVIG infusion in the management of Rh hemolytic disease in newborns [6,7]. It can be hypothesized that by the same mechanism it would be useful if IVIG is given directly to the fetus, but this has not been studied and only a few reports exist [8]. Therefore, this study was planned to evaluate the usefulness of direct intravascular immunoglobulin in severe Rh-immunized pregnancies requiring IUTs in decreasing fetal red cell hemolysis.…”